Deniz Atasoy
@AtasoyLab
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Assoc. Prof. @IowaNeuroPharm, interested in circuits for appetite & metabolism, circadian regulation, obesity & hypoglycemia. Atlas' & Zeus'(pitsky) dad.
Iowa City
Joined June 2019
🧠A new generation of biosensors is helping researchers observe brain activity with greater precision. Developed in collaboration with @HHMIJanelia, iGluSnFr4f and iGluSnFr4s make it easier to detect glutamate - an important neurotransmitter. 🔗 ​ https://t.co/5mtHTInx5R
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Congratulations to Michael Welsh, MD, for being awarded the prestigious 2025 @LaskerFDN Clinical Medical Research Award for 40 years of life-changing research on #CysticFibrosis. https://t.co/CmpokXbcbU
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We are proud of @omsinghneurosci's new study. Supported by @SepidehSheybani et al, Om's work identifies GHSR-expressing SCN neurons as regulating food intake at one particular time of day, accounting for at least 7% of a mouse’s body weight. https://t.co/a3sjPQiOsL
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Engineered Brain Receptors Break the Cycle of Cocaine Addiction | Technology Networks
technologynetworks.com
Researchers at the University of California, San Diego and the National Institute on Drug Abuse have developed a new biochemical approach to combat addiction, which shows promising results in...
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We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! https://t.co/OabhjeWV1q
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We created a python package for photometry post-hoc analysis using bootstrapping confidence Intervals No more AUC or time bins analysis! Ever Follow our simple step by step instructions. Thanks.... @DrReal82 @ClaireFoldi @philURDB @Stark_BrainSci
https://t.co/I9yLlqwFIb
biorxiv.org
Fiber photometry is a neuroscience technique that can continuously monitor in vivo fluorescence to assess population neural activity or neuropeptide/transmitter release in freely behaving animals....
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Excited to share our new study arguing for the existence of parallel neural pathways mediated by LepR or non-LepR neurons that each is sufficient to drive obesity. The obesity driven by non-LepR neurons is relevant to DIO and can be a novel neural basis for leptin resistance.
An alternative neural basis underlying leptin resistance
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A new study in mice uncovers a stress-sensing circuit that interacts with light to influence circadian outputs. The work offers a roadmap for exploring the circuits linking light, circadian/sleep, and stress-related psychiatric disorders. https://t.co/lJsbBx3C8L
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A neurotensin-dependent neural circuit mechanism that links the devaluation of hedonic foods with #obesity
nature.com
Nature - In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding...
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BREAKING: People are allegedly being suspended on X in Turkey for posting videos of these protests against Erdoğan’s corrupt and repressive regime. Keep sharing everywhere.
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Thalamic opioids from POMC satiety neurons switch on sugar appetite | Science
science.org
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the...
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"A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs" https://t.co/auo9EUDJID
biorxiv.org
Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturi...
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Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety https://t.co/EbPIl6ptxU
nature.com
Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.
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Multiple distinct cNTS subtypes including GCG+ cells are marked by differences in temporal dynamics, sensory modalities, associated visceral organs and ascending sensory inputs controlling feeding pathways @NatureGenet
nature.com
Nature Neuroscience - This study identifies parallel gut–brain pathways that fine-tune feeding. Distinct brainstem neurons and visceral afferents either sense esophageal stretch to regulate...
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Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss
nature.com
Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...
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Tirzepatide prevents progression to type 2 diabetes by 93% in those with prediabetes and obesity🤯 📉Weight loss of 19.7% was sustained over 3 years with the highest dose. New trial results published in NEJM today https://t.co/ZzQthJvQFx
nejm.org
Obesity is a chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial...
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Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum https://t.co/73YFPgs3i4
#biorxiv_neursci
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Outstanding paper by @StephenXZhang and @andermann_mark, showing gradual promotion of satiation by accumulated cAMP downstream of MC4R and NPYR. Congratulations to whole team. https://t.co/JzAkZhj9qJ
nature.com
Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...
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