Arvind S Pillai
@ArvindSPillai1
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Washington Research Foundation Postdoctoral fellow, Institute of protein design. Formerly Phd student @UChicago doing evolutionary biochemistry. I also do art.
Joined October 2019
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others!
nature.com
Nature - We investigate the de novo design of allostery and suggest that it can arise from global coupling of the energetics of protein substructures without optimized allosteric communication...
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RT @ScienceStowers: We’re proud to welcome two bold scientific minds to the Institute! Arvind Pillai, PhD, joins as Assistant Investigator….
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RT @grocklin: Small proteins can be more complex than they look!. We know proteins fluctuate between different conformations- but how much?….
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Read this awesome paper from @carway2nar about the biophysical and genetic mechanisms by which proteins evolve to assemble into highly specific assemblies of distinct molecular units. Proud to have contributed!.
My first first-author paper is out! It was an amazing collaborative effort with a lot of amazing people including @ArvindSPillai1 and @JoeThorntonLab. Please read if you like things involving evolution and biochemistry.
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RT @carway2nar: My first first-author paper is out! It was an amazing collaborative effort with a lot of amazing people including @ArvindSP….
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RT @wgrubbe_: Excited and proud to have this paper published with @NatureComms today! Great project led by @DrJuanLMendoza at @UChicagoPME….
nature.com
Nature Communications - IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM...
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RT @AnnikaPhilomin: Thrilled to see our work on protein nanocage design published in @Nature! These nanocages have exciting potential appli….
nature.com
Nature - Using viral capsid architectures as template for design, higher triangulation number nanocages that require symmetry breaking offer potential advances in targeted delivery and...
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RT @KaHochberg: New paper from us and @erblabs by @schulluc : It's about the evolution of essentiality. This ques….
embopress.org
imageimageDuring evolution, Rubisco, the carboxylase of photosynthesis, has become completely dependent on an additional subunit. This dependence is found to have evolved through multiple, genetica...
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Read this amazing work from Adam & co on designing complexes whose kinetics of assembly and disassembly can be allosterically controlled with remarkable precision!.
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.
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RT @definitelyphil: #CrispyShifty proteins mentioned - highlight of the announcement for me 😁 @ArvindSPillai1 @FloPraetorius .
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RT @Mohamad_Abedi: David didn’t just launch a field that's transforming science and soon, our lives—he did it while being an incredible men….
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RT @slavov_n: A reminder that proteins are highly dynamic molecules. ◼ We have made progress in measuring & predicting static protein str….
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RT @MoSephius: I think the actual "work" of academia is pretty fun and intrinsically rewarding. The discipline would be a lot better if we….
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RT @opazolab: We are pleased to announce our latest work, in which we report the characterization of a new monoamine oxidase family member….
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Brooke is the most talented,productive and empathetic scientist I personally know- if you are a young marine ecologist looking to join a group with a bright future and excellent mentorship, you should strongly consider joining to the Weigel lab at @HopkinsMarine @Stanford !.
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RT @definitelyphil: Love this article by @schubertcm @geekwire on what we're trying to do here in #Seattle at @Xaira_Thera @JustasDauparas….
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RT @KaHochberg: This is a monumental paper from Arvind. Not only did work out in his PhD how the classic model for allostery haemoglobin ev….
nature.com
Nature - We investigate the de novo design of allostery and suggest that it can arise from global coupling of the energetics of protein substructures without optimized allosteric communication...
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RT @definitelyphil: Awesome paper in @Nature! @ArvindSPillai1 achieved theoretically perfect ligand binding cooperativity with a hill coeff….
nature.com
Nature - We investigate the de novo design of allostery and suggest that it can arise from global coupling of the energetics of protein substructures without optimized allosteric communication...
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RT @AnnikaPhilomin: Super excited to share that our work on de novo design of allosteric proteins is now out in nature!👩🏽🔬. Huge thank you….
nature.com
Nature - We investigate the de novo design of allostery and suggest that it can arise from global coupling of the energetics of protein substructures without optimized allosteric communication...
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I'd like to also acknowledge the following co-authors for important contributions to the work! @definitelyphil Andrew Borst, @Skotheim42, cullen demakis,@adam_broerman and the Baker Lab + Institute of Protein Design as a whole!.
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