cweidle Profile
cweidle

@cweidle1

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112
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Joined December 2018
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@cweidle1
cweidle
@cweidle1
1 year
Not everyday you get tweeted by the pdb. 😊.
@buildmodels
rcsb pdb 💉🧬💻🔬💊🌱🧠🦠
@buildmodels
1 year
New PDB structure reminds me of . an Escher staircase.Explore in 3D at RCSB PDB:
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@cweidle1
cweidle
@cweidle1
4 years
RT @Safia_SJ: I am happy to share that my first * first author paper is finally accepted and made it to PLOS pathogens :) ..
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pubmed.ncbi.nlm.nih.gov
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at...
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@cweidle1
cweidle
@cweidle1
4 years
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nature.com
Nature Communications - Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated...
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@cweidle1
cweidle
@cweidle1
5 years
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@cweidle1
cweidle
@cweidle1
5 years
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biorxiv.org
Peptide drugs targeting class B1 GPCRs can treat multiple diseases, however there remains substantial interest in the development of orally delivered non-peptide drugs. Here we reveal unexpected...
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@cweidle1
cweidle
@cweidle1
5 years
RT @dahilger: I am happy to share our latest work on the differences in G protein activation by family A and family B GPCRs. I am very grat….
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@cweidle1
cweidle
@cweidle1
5 years
nature.com
Nature Communications - SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the...
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@cweidle1
cweidle
@cweidle1
5 years
RT @sunbingfa: Our study, through wonderful collaboration with @LillyPad, reports and characterizes a small molecule positive allosteric mo….
nature.com
Nature Chemical Biology - A new ligand against the GPCR GLP-1R acts as a positive allosteric modulator, binding both the receptor and the orthosteric ligand, accessing the peptide ligand within the...
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@cweidle1
cweidle
@cweidle1
5 years
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@cweidle1
cweidle
@cweidle1
5 years
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@cweidle1
cweidle
@cweidle1
5 years
RT @veeslerlab: We designed a SARS-CoV-2 spike glycoprotein covalently shut closed, and showed it is also applicable to SARS-CoV, to suppor….
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biorxiv.org
The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate...
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@cweidle1
cweidle
@cweidle1
5 years
RT @veeslerlab: Watch out SARS-CoV-2, we are coming for you! .Our manuscript describing the isolation and structural characterization of th….
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nature.com
Nature - The monoclonal antibody S309, identified from memory B cells of an individual infected with SARS-CoV in 2003, or antibody cocktails that contain this antibody potently neutralize SARS-CoV-2.
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@cweidle1
cweidle
@cweidle1
5 years
RT @druselabs1: PDB release this week:.15 #COVID19 structures.7 fragment screening structures of main protease. #structuralbiology. https:/….
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@cweidle1
cweidle
@cweidle1
5 years
RT @DiamondLightSou: You can also use our online submission form here:
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@cweidle1
cweidle
@cweidle1
7 years
RT @andrewjborst: Glycans are important elements to consider when designing immunogens for HIV-1 vaccination. Our latest manuscript reveals….
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elifesciences.org
An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites,...
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