XairaTherapeutics
@Xaira_Thera
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An integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease
Joined April 2024
RT @_annhuang: 12/12.This work is the result of an incredible collaboration between @Xaira_Thera and @ForesiteLabs! Many thanks to all the….
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RT @_annhuang: 11/12.In conclusion, FiCS Perturb-seq is a robust platform for executing large-scale perturbation screens, enabling the crea….
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RT @_annhuang: 10/12.As part of this work, we’re releasing X-Atlas/Orion, the largest publicly available Perturb-seq atlas to date! It cont….
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RT @_annhuang: 9/12.This approach moves beyond treating genetic perturbations as simple on vs off switches, enabling a more nuanced underst….
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RT @_annhuang: 8/12.Excitingly, we find that sgRNA abundance can be used as a reliable proxy for gene knockdown efficiency. This enables th….
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RT @_annhuang: 7/12.Data generated using FiCS Perturb-seq is biologically meaningful. We show it validates physical protein-protein interac….
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RT @_annhuang: 6/12.Furthermore, FiCS Perturb-seq also delivers remarkably consistent data with significantly lower batch-to-batch variatio….
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RT @_annhuang: 5/12.A major bottleneck of perturbation data generation is the need to use fresh cells. Using FiCS Perturb-seq, we show that….
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RT @_annhuang: 4/12.Using FiCS Perturb-seq, we performed two genome-wide screens in HCT116 and HEK293T cell lines. Both screens had better….
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RT @_annhuang: 3/12.To overcome these challenges, we developed FiCS Perturb-seq, a platform that integrates fixation, FACS enrichment, cryo….
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RT @_annhuang: 2/12.This work was inspired by the need for large, high-quality perturbation datasets to train foundation models that unders….
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Come along for the ride as our sr bioinformatics scientist and first author @_annhuang takes us on a tweetorial about our X-Atlas/Orion preprint.
1/12.Excited to share our team's latest work and the first @xaira_thera preprint! Here, we introduce FiCS Perturb-seq, an industrialized platform for generating scaleable, high-quality perturbation data. 📄 Read the preprint:
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Today, we're releasing the fuel for the next generation of AI in biology 🧬. X-Atlas/Orion is now the largest public genome-wide Perturb-seq dataset, built to create better “virtual cell” models and accelerate drug discovery. Learn more:
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We're excited to welcome Paulo Fontoura to our team as chief medical officer! He brings a wealth of experience and deep insight to help advance our mission of leveraging AI to transform drug discovery. More info in today's announcement:
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When science meets AI, cool things happen! Like earning a spot on @FortuneMagazine’s 50 AI Innovators list. Thanks, @Johnnerkell for sitting down with our CEO Marc Tessier-Lavigne to learn how we’re using AI to transform drug discovery.
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Thank you to @stephzhan, partner at @sequoia for her @TEDAI2024 talk! Loved her highlights on our company and mission.
8/ AI also holds massive potential in pushing forward scientific discovery. The drug discovery process is inefficient and prone to failure - on average it takes 24 projects to get to 1 approved drug, 13 years and a few billion dollars later. @Xaira_Thera is changing that.
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Congratulations to our co-founder, David Baker, and to John Jumper and @demishassabis of Google DeepMind, for sharing this year’s Nobel Prize in Chemistry! Their stunning breakthroughs have provided the foundation for our work at Xaira, and we couldn't be more proud.
“I got the phone call and my wife promptly started screaming.”. The 2024 #NobelPrize in Chemistry gave David Baker’s household an early wake up call. We talk about the potential of building new proteins and the inspirational effect his fellow laureates have had on his field.
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Thank you! Very honored to make this short list.
With over $1 billion in committed capital, this company is the biggest AI bet in biotech. Congrats to @Xaira_Thera on making the 2024 Endpoints 11.
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🌙Over the moon that we've been named one of @LinkedIn’s Top US Startups of 2024! Thanks to our employees who made this possible.
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Fun times at our science symposium last week in the Bay Area, which included a lesson on how to say our name.
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