William Grubbe
@wgrubbe_
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Joined October 2012
Excited and proud to have this paper published with @NatureComms today! Great project led by @DrJuanLMendoza at @UChicagoPME and @HHMINEWS. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results!
nature.com
Nature Communications - IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM...
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I am happy to share that we have a great opportunity for a postdoctoral scientist. Please share.
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Congratulations to the new graduates of @UChicagoPME !!
Today, the University of Chicago Pritzker School of Molecular Engineering celebrated the Class of 2025—an exceptional group of innovators and researchers ready to shape the future of #science, #engineering, and #technology. From breakthroughs in quantum science, health, and
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Fantastic work coming out of @DrJuanLMendoza lab recently! Structural and signaling dynamics of an interesting cytokine in the interferon family, IFNL4, thanks to a breakthrough that allowed the team to express the protein in high quantity and purity. https://t.co/tab1C3QVeC
nature.com
Nature Communications - IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM...
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Grateful to have our work featured by the editors!
@UChicagoPME This work also received one of the Editor's Highlights
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#UChicagoPME researchers in the @DrJuanLMendoza Group have developed a method to produce an immune protein to facilitate future studies on why it makes immune responses worse. 📰 https://t.co/YWS0LUM87Q
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Thank you @UChicagoPME for this great write up covering our new story! https://t.co/zN1NfIqM14
pme.uchicago.edu
UChicago PME researchers developed a method to produce a mysterious immune protein termed IFNλ4 in the lab, a first step toward understanding why people with the gene for this protein are more...
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What is needed to accelerate enzyme engineering using machine learning? #Data We develop a ML-guided platform that integrates DNA assembly, gene expression, and functional assays. ML models predict improved variants. @akarimlab @NUSynBio @NatureComms
https://t.co/BmlojOIK4A
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I’m excited to share @wgrubbe_ paper was just published. He was relentless and methodical. Thank you to all our authors and collaborators at UChicago: Bixia, Minglei, Engin at the NIH: Jake and team. Special thanks to @prokuninaolsson
nature.com
Nature Communications - IFNλ4 has posed a conundrum in human immunology, leading to structural and functional questions about the protein. Here, the authors use protein engineering and cryoEM...
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🚨 New Episode of In Translation 🚨 Great sitting down with @JefBoeke and @theicechol to talk synthetic genomics! Hope you enjoy!
🚨 New In Translation episode! @theicechol and @wgrubbe_ sit down with @JefBoeke, a trailblazer in synthetic genomics. From retrotransposons to Sc2.0, Jef takes us through his scientific journey and the effort to build the first synthetic yeast genome.
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We are all born with a genetic lottery. Millions of T cell receptors are what we have with a hope to defend all cancer and viruses. What if that's not enough? Hope our work can give an interesting answer to you.
biorxiv.org
Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance, and specific targeting of these peptide-MHC (pMHC) complexes could have...
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Great story and great technology from @adam_broerman, @UWproteindesign, and others. Excited to apply this to the next generation of cytokine therapeutics! #proteindesign
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. https://t.co/jBIHq10Ykd
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Great talk @DrJuanLMendoza! Having a great time in Seoul and thank you to @CytokineSociety for the generous Travel Award allowing me to present my work here!
I was happy to have presented the work of Will Grubbe, today, highlighting his significant contribution to IFN biology at Cytokines 2024. @wgrubbe_ @CytokineSociety PS. photo before session 😆
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Call for Abstract Extended Deadline for Cytokines 2024 / KAI 2024 - May 30, 2024 (23:59 KST)! For ICIS Student/Postdoc members the travel award application is also extended until May 30th #cytokines2024 Please retweet and plan to share your cytokine science at the joint meeting.
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Protein folding is so important. In 2023, DeepMind won the $250,000 Lasker award for their solution to the problem. A lot of people have asked me to explain protein folding in simple, understandable terms. Here is my attempt at explaining just the problem. 🧵OPEN THE THREAD🧵
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Great talking with @PracheeAC and @Andrew_C_Hunt about @ArcadiaScience! Please give it a listen if you want to learn more. @EngBioRC
New podcast episode alert! @Andrew_C_Hunt and @doubleyouSG talk with @PracheeAC of @ArcadiaScience about mining biology for useful tools, science publishing, new structures for science organizations, and much more! https://t.co/kecEpKzCFP
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