Caillier Alexia
@AlexiaCaillier
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Postdoc at Loyola University Chicago in the Oakes Lab
Chicago, Illinois
Joined September 2020
Proud to be on the cover of @JCellBiol π€©
Our October issue is out! https://t.co/l8Eiamr5Kp The cover shows a color-coded projection through time of confocal images of a mouse primary Th1 T cell expressing EGFP-Lifeact migrating in confinement. From @AlexiaCaillier, @pwoakes et al. ( https://t.co/dN8J8i209s)
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Caillier, @pwoakes et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://t.co/s9HVy5sUlI π In Immune Cell Biology 2025: https://t.co/4NsBZ55NQ0
#AAI2025
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Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion: https://t.co/m2vcqZHpRh
#AAI2025
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π’ Mar 17: CPS Special Seminar! Join us for the in-person presentation by Dr. Patrick Oakes, hosted by Dr. Guy Tanentzapf: "Strain Signaling: βHow LIM domain proteins coordinate mechanotransductionat adhesionsβ" π· Mar 17, 1pm in LSC 3 & Zoom
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Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @J_Cell_Sci: https://t.co/vEwsJ8PMuy
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.@AlexiaCaillier, @pwoakes et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://t.co/uqM5GjkFCS In #Mechanobiology 2025: https://t.co/4qt10IYkcz
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.@JCellBiol's new collection examines the mechanical properties and interactions that shape the fundamental operations and structures of cells. Delve into diverse mechanical properties of membranes, organelles and other structures within & among cells π https://t.co/ga3FS2yXXJ
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Excited that the peer-reviewed version of our fascin structure paper is now out in @NatureSMB. Thanks very much to the referees for their constructive feedback.
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It's a pleasure to share the first manuscript from my lab!
biorxiv.org
T cell migration into inflamed tissue is a key control point in the inflammatory response and relies on integrin interactions with their endothelial ligands. Here, we identify the signaling scaffold...
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I'm spending more time on the other social network these days, but it's still worth posting that we'll be at #cellbio24 #ASCB! If you like LIM proteins or septins come check out our posters:
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Help choose JCBβs cover of the year! π¬ Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. ποΈ Voting closes on Friday, December 20! Have your say in celebrating the beauty of science π https://t.co/VgqzLZQXD8
#CellBio2024
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We wrote a fun review all about the different types of mechanosensing and the ways cells regulate these important processes. Check it out!
In their Review, @Stefano_R_Sala, @AlexiaCaillier and @pwoakes @LoyolaChicago discuss the principles and regulation of mechanosensing. https://t.co/4xCMpqi2TZ
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In their Review, @Stefano_R_Sala, @AlexiaCaillier and @pwoakes @LoyolaChicago discuss the principles and regulation of mechanosensing. https://t.co/4xCMpqi2TZ
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Looking for a summer read?ποΈππ You're in luck π. Our paper on optogenetic leader cells is out @NaturePhysics. We found a force-velocity relation for collective cell migration. Experiments by @LeoneRossetti, theory by @ricardalert. @IBECBarcelona
https://t.co/eAxUVIDs5P
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What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721
https://t.co/Gu1aPN2nI9
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Video shows Th1 Vinculin-EGFP cells sandwiched between two acrylamide gels of 460 Pa coated with FN. From @AlexiaCaillier, @pwoakes et al. showing that T cells use focal adhesions to pull themselves through confined environments https://t.co/iXt9Q8jr9H
#Immunology #Adhesion
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T cells use focal adhesions to pull themselves through confined environments, say Alexia Caillier (@AlexiaCaillier), Patrick Oakes (@pwoakes) @LoyolaChicago and colleagues: https://t.co/hPCpgYpADo
#Immunology #Migration #motility #Biophysics #Adhesion #integrins
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How do cells squeeze their large nucleus through tight spaces? In work now published at @J_Cell_Sci, we show that cancer cells can use contraction of the rear cortex to generate pressure in the back and push the nucleus during confined #migration: https://t.co/CGGtx0VzGU
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Really proud to see this paper finally out ! π€©ππΎ Thank you to @JCellBiol and the reviewers for their precious comments that definitely strengthened our work. See our previous thread for most of the details !
Ever wonder about the mechanics of immune cell #migration? @AlexiaCaillier, @pwoakes @LoyolaChicago and colleagues find T cells form integrin mediated focal adhesions to pull themselves through confined spaces. https://t.co/iUGTVhdT9o
#Immunology #Adhesion
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Ever wonder about the mechanics of immune cell #migration? @AlexiaCaillier, @pwoakes @LoyolaChicago and colleagues find T cells form integrin mediated focal adhesions to pull themselves through confined spaces. https://t.co/iUGTVhdT9o
#Immunology #Adhesion
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