Alex Shcheglovitov 🇺🇦
@AlexShcheglovit
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Associate Professor @shcheglovitov @UUNeurobiology @UUtah studying human 🧠 development in health and disease using #iPSC & #organoid
Salt Lake City, UT
Joined January 2012
📣 Our protocol to generate brain #organoids from #StemCell derived Single Neural Rosettes 👇
Our lab generates brain organoids from isolated single neural rosettes - and now it's all in a new @NatureProtocols paper! Step-by-step instructions to try it yourself👇 https://t.co/tRTUTSbvJW
#Organoids #Neuroscience #StemCells
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Honored to give a seminar in Ukrainian at the oldest Ukrainian Scientific Society in US - the only US nonprofit supporting scientists and medical students in Ukraine during this difficult time! Thank you!
Tune into our livestream today at 5:00 PM with University of Utah Associate Professor of Neurobiology @AlexShcheglovit - https://t.co/AR6xFTdSAX
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Look forward to visiting UCLA next week!!
Join us on Thursday, October 2 as Dr. @AlexShcheglovit 🇺🇦 of @UUtah presents, "Neural rosette-based brain organoids: A controlled stem cell-derived model to study human neurodevelopment and disease” at 12pm in CHS 13-105. Register today: ➡️ https://t.co/KvMgavy0rj
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This is a cool one. We leveraged single cell analysis and in vivo calcium imaging to examine how ASD risk gene Shank3 alters the activity of heterogeneous cell populations during anxiety. Congrats to Hailee,@damhyeonkwak , and Prakash! https://t.co/zyd5YeC4N4
biorxiv.org
The prefrontal cortex is a central regulator of complex behaviors, including social interaction and anxiety-related behaviors. The prefrontal cortex encodes these behaviors using heterogeneous groups...
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NIH announces end to funding for animal-only studies
drugdiscoverytrends.com
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
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Really interesting study on social information processing in the prefrontal cortex 👇
Excited to see this in print this morning, coincidentally on the lab's birthday! Here we tackle the question of how the PFC multiplexes social and contextual information using overlapping ensembles of neurons.
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New Article! Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes https://t.co/QoFZ4o35MJ
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Great analytics! Indeed, it is “brutally difficult” to do rigorous biomedical research and cutting NIH funding may have detrimental consequences. “Cutting science won’t balance the budget—but it might bankrupt our future.”
So, should we reduce academic science spending? The data is unequivocal: we should increase it.
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Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate.
biorxiv.org
Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic...
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Brain cancer leverages the same tools as the developing brain 🧠! In our new study, published today in @Nature, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch
https://t.co/8t8WHyQiS4
nature.com
Nature - Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.
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Great meeting- highly recommend!! 👇
We are excited to continue the GRC on Functional Genomics of Human Brain Development and Disease in April 2025. Please check out the great line-up of speakers. Oral presentation slots and poster presentations are still open! Deadline March 9th https://t.co/3218PfBZIB
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Way to go @arif55dml !!👏👏
@arif55dml presented his research project at CSHL meeting on brain #organoids! Thanks @Sergiu_P_Pasca and @UPenn_SongMing for the opportunity!
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Temporally distinct 3D multi-omic dynamics in the developing human brain | Nature
nature.com
Nature - Using a single-nucleus multi-omics approach, a study jointly profiles the reorganization of the epigenome and the three-dimensional chromatin conformation during the development of the...
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Examine multimodal data from thousands of cells across three mammalian species with the Cell Type Knowledge Explorer, an open science resource developed with BICCN and supported by the BRAIN Initiative Alliance. Explore it at: https://t.co/NWkHQWleri
#BICCN #studyBRAIN
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🔬 Are you eager to dive into the world of light microscopy and learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 https://t.co/IgKwGlQKPg
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In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life https://t.co/dgvi6mMq1a
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