Prashant Kumar, PhD
@0kumarprashant
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PhD (@IiserMohali), Postdoc (@queensu, @QueensChem)
Joined February 2020
ATROPISOMERIC INDENES through asymmetric palladium-catalyzed Suzuki–Miyaura cross-coupling reactions @J_A_C_S . This work underscores the importance of axially chiral indenes and addresses a notable gap in the field. Many congratulations to the authors! 👏
Atropisomeric Indene (AroInd) Libraries: Design, Catalytic Synthesis, and Applications | Journal of the American Chemical Society
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Atropisomeric Indene (AroInd) Libraries: Design, Catalytic Synthesis, and Applications | Journal of the American Chemical Society
pubs.acs.org
The development of chiral indenyl metal complexes has been hindered by inefficient synthetic methods, significantly lagging behind the well-established Cp metal complexes. In this study, we present a...
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Thrilled to share the first paper from our group at UCLA, online today in Science: “Biocatalytic, Asymmetric Radical Hydrogenation of Unactivated Alkenes” @uclachem @ScienceMagazine
https://t.co/YCtGp91kd2
science.org
Alkene hydrogenation is a cornerstone of chemical synthesis, yet enzymatic strategies remain limited to electron deficient substrates via hydride transfer. Using heme enzymes, we unlock a hydrogena...
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Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @Nature that exchanges O within an oxetane for N, S, C & even dual atoms, simplifying access to a variety of non-aromatic cyclic pharmacophores & enabling late-stage editing of complex
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Enantioselective Total Synthesis of (−)-Novofumigatonin | Journal of the American Chemical Society @ETH_DCHAB @ETH_en @ETH
pubs.acs.org
We disclose the first and enantioselective synthesis of novofumigatonin, an ortholactone meroterpenoid natural product featuring an unprecedented 7/6/5/6/5/5 hexacyclic skeleton. On a strategic...
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Happy to share our recent #OrgLett. article on 'Asymmetric @totalsynthesis of (+)-shearilicine'. Congratulations to @NandaKisho34936 @ranjitmurmu0015 @MOUMITA23914029 @SouvikBisw76894 Read the article here: https://t.co/1v5Ixgzlpf
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Out today in @J_A_C_S is the first synthesis from our group!! We report a convergent and stereoselective total synthesis of the nominal structure of Talaromyolide D. Huge congrats to Bo and Alex! @nyuchemistry @TotalSynthesis
https://t.co/1MJBXeBXmc
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Photocatalytic Asymmetric Oxidation of Phosphines with Water | Journal of the American Chemical Society
pubs.acs.org
P-chiral tertiary phosphine oxides (TPOs) hold significant synthetic value due to their capacity to serve as versatile precursors for a wide range of valuable P-chiral phosphorus-containing compoun...
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Check out our @J_A_C_S on accessing chiral C–N axes under cobalt catalysis! Congrats to @iamAbirdas @maity_pritam02 Kumaran & @Richard_UKT for DFT Thanks to @IFCPAR for funding & @iitkanpur for infra shout out to lab @Basker_IITK @Chemistry_IITK @director_iitk #asymmetric
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Interesting!! Further development involving benzylic gem-diacetates in Pd catalysis. Previously demonstrated in our work:
pubs.acs.org
Unlike that of benzyl acetates, the chemistry of benzyl gem-diacetates is rarely explored under metal catalysis. Here, we describe the first palladium-catalyzed cascade annulative allylic alkylation...
Stereodivergent synthesis of benzylic alcohol derivatives enabled by Pd/Cu co-catalyzed asymmetric benzylic substitution reaction https://t.co/yuAtHTAS42
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atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 https://t.co/76QEU36cr3
@ASimlandy @0iTurki @pengliu_group
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Fascinating work! Elegant and fundamental strategy for accessing versatile axially chiral styrene precursors
atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 https://t.co/76QEU36cr3
@ASimlandy @0iTurki @pengliu_group
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Our latest nickel catalysis paper is out now in JACS ASAP! See Wen, Calvin, and Will's (in collaboration with Professor Christina Li) work on terpene alkaloid natural product synthesis through [4+1]-cycloaddition below! 🧪 https://t.co/u4vDyNsnrS
pubs.acs.org
Intramolecular Diels–Alder reactions are privileged strategic disconnections in the synthesis of polycyclic natural products containing six-membered rings. The analogous [4 + 1]-cycloaddition may...
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Pd-Catalyzed Photoinduced Interceptive Decarboxylative Allylation | Journal of the American Chemical Society @rmartinICIQ @ICIQchem @_BIST @universitatURV @TotalSyntheses
pubs.acs.org
Herein, we describe a photoinduced Pd-catalyzed interceptive decarboxylative allylation of allyl esters. Our protocol provides a new gateway to enable atom pair swaps or a series of contractions and...
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Salute to the Indian Armed Forces and its brave soldiers for successful execution of #OperationSindoor 🫡 It reflects India's unwavering commitment to national security. #IndianArmy #NationFirst @EduMinOfIndia
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Concise Enantioselective #TotalSyntheses of Rearranged ent-Trachylobane Diterpenoids (–)-Wallichanols A and B by Dattatraya H. Dethe, Nitin Sharma, and Sakshi Juyal in @angew_chem
https://t.co/DDtoifoaBO
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Empowering Diastereoselective Cyclopropanation of Unactivated Alkenes with Sulfur Ylides through Nucleopalladation | Journal of the American Chemical Society @iitmadras @TotalSyntheses @JainDeemedtbUnv
pubs.acs.org
Regio- and stereoselective cyclopropanation of unactivated alkenes under mild conditions remains a challenging yet fundamental transformation. We present a versatile palladium(II)-catalyzed method...
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Our work on the first sigmatropic rearrangement with [1.1.1]propellane for accessing functionalized MCBs and its application in the synthesis of BCHs is out @ChemRxiv. Thanks, @serbonline @iiscbangalore, for the funding. https://t.co/szLAwjKeW4
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Check out our recent work published in @JOC_OL @acs Domino Approach to Heterocycles-Based Unsymmetrical Triarylmethanes through Heteroannulation of 2‑(2-Enynyl)pyridines with Enaminones. From @RVijayaAnand1 Lab @DCS_IISERMOHALI
https://t.co/TUfKqxjp0G
pubs.acs.org
Herein, we report a copper-catalyzed protocol to access unsymmetrical triarylmethanes containing both indolizine and the chromone scaffolds in the same molecule via a 5-endo-dig cyclization of...
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Congratulations to Toni, Jeremy, Jing and @BreugstLab for our recent @angew_chem An unusual 2C enantioselective annulation possible by rethinking how this intermediate is accessed using phosphine organicatalysis. https://t.co/paazUZFEV1
onlinelibrary.wiley.com
Vinylphosphonium intermediates, commonly accessed from ynoates, undergo normal and reverse polarity couplings. Herein we exploit β-iodoenoates as alternatives to ynoates. As a consequence, we have...
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