Zach Walsh
@zwalsh96
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@columbiamed md/phd candidate | t cell engineering and immunogenetics @ izar lab | nci f30 fellow
New York, USA
Joined April 2023
Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:.
Excited to share a new paper: @CellCellPress: a framework to accelerate variant classification, diagnosis & treatment of immune disorders & genetic disorders more broadly. Led by superstar, juggernaut & future dermatologist @zwalsh96
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RT @CureMelanoma: For this week’s #MRFResearchWednesday, we’re spotlighting 2025 Medical Student Grant Awardee @Zwalsh96 of @ColumbiaMed, w….
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RT @LomvardasLab: Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical….
cell.com
In lieu of traditional genetic variant testing approaches, an approach using scalable variant classification in primary human T cells with a clinically relevant readout can inform rapid diagnosis and...
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Great to see our work featured by @ColumbiaMed!. New Method Speeds Diagnosis of Rare Genetic Disease
cuimc.columbia.edu
A Columbia study addresses a key challenge in the diagnosis of rare genetic disorders.
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RT @CellCellPress: Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accel….
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RT @LabWaggoner: Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical….
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Excited to be presenting more of our scalable variant classification work tomorrow at @ImmunologyAAI #IMMUNOLOGY2025. Check it out if you are interested in #CRISPR base editing, forward genetic screening, or immunogenetics! My talk starts at 8:45 AM tomorrow (May 5) in Room 312!
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Work that was made possible by brilliant mentorship from @BizarMd, invaluable contributions by @FrangiehChris, Clarissa Heck, @JCA_Melms, @NeehaKothapalli among many others, and invaluable guidance and support from our field-leading collaborators @joshuamilner2 and @BogunovicLab.
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Truly amazing experience to get to present our variant reclassification work at the opening plenary session of @ClinImmSoc 2025. Couldn’t have asked for a better audience for this work, as evidenced by so many insightful questions and conversations!
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Had a wonderful experience presenting our work developing a scalable variant classification approach for inborn errors of immunity at @JointMeeting @the_asci @A_P_S_A last week! And very grateful to have received a travel award to support my attendance.
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RT @SomnathTagore: Happy to share our manuscript “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases”….
nature.com
Nature Medicine - Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in...
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RT @varianteffects: 🗓️Join us TODAY! March 4th .*⃣ Zachary Walsh (@zwalsh96 , @ColumbiaMed) on scalable #Crispr screens for variant effect….
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RT @BizarMd: Congratulations to @lcaprio412 @SomnathTagore, many people in my group, and outstanding collaborators @DenisSchapiro @KresBest….
nature.com
Nature Medicine - Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in...
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Very excited to be presenting on March 4! If you are interested in T cell engineering, immunotherapies, or studying variant effects, check it out -- more info below.
Join us for the Variant Effect Seminar Series on March 4!.*⃣Zachary Walsh (@zwalsh96) on scalable CRISPR screens for variant effects in T cells. *⃣Malvika Tejura & Shawn Fayer (@ShawnFayerGC) on improving variant effect predictors for clinical use.
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Huge congratulations to my good friend and former Fry lab labmate @KoleDeGolier on his beautiful paper published in Nature Immunology!.
I am thrilled to share my first-ever first-author publication in @NatImmunol! Huge thanks to everyone who contributed! See comments for more. #celltherapy #immunology #immunotherapy #CARTcells.
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RT @MatthewACoelho: Today we report in @NatureGenet the genetic landscape of cancer drug resistance mechanisms from CRISPR base editing scr….
nature.com
Nature Genetics - Base editing screens of 11 cancer genes identify four functional classes of variants that collectively underpin sensitivity and resistance to ten commonly used drugs in cancer...
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Pleased to share that our recently published work on CRISPR base editing in primary human T cells has been featured in @nyphospital Advances! Check out this article, where my mentor @BizarMd and I were interviewed about our work:.
nyp.org
Using Protein Variants to Alter Immune Cell Function for Cancer Therapeutics
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RT @stephentang23: Thrilled, and also in a bit of disbelief, to see our paper featured on the cover of @ScienceMagazine! "Finding Neo" wasn….
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