Johannes Melms
@JCA_Melms
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Excited to share our new study on the ecosystem of treatment-naïve melanoma brain metastasis (MBM) published in @CellCellPress today. A team effort from the Izar lab with @BizarMD @_janabiermann and many collaborators.
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RT @BizarMd: Excited to share a new paper: @CellCellPress: a framework to accelerate variant classification, diagno….
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RT @ivazquezgarcia: Excited to share a commentary on emerging challenges in understanding and targeting cancer genome instability to improv….
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RT @NatureBiotech: Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens .
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RT @columbiacancer: New research from @BizarMd, shows that higher blood glucose levels 'attract' cancer cells to spread to the liver. Lower….
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Very happy to share @meri_rogava's work on liver-metastatic organotropism in melanoma! Awesome work from discovery to mechanism. Great to have you as a post-doc colleague in the @BizarMd group - first in Boston, then New York. Congratulations!!!.
Very excited to share new work from the lab dissecting mechanisms of liver-metastatic organotropism in melanoma and other cancers. Huge congrats to fearless post-doc @meri_rogava (on the job market!) who led this multi-year study! Below a brief summary.
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Amazing to see how robustly results converge with just published work by @MarsonLab highlighting the crucial role of PIK3CD/R1 signaling in human T cells.
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RT @zwalsh96: Excited to share our new preprint! We developed methods for - and executed - pooled base editor screens of >100 critical T ce….
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Very happy to share our preprint on pooled base editing in primary human T cells to discover genetic variants modulating T cell function. Incredible effort by MD/PhD student @zwalsh96 and other members of the @BizarMd lab at @Columbia.
Interested in T cell biology? Cellular immunotherapies? Base editing? And an amazing example for scientific reproducibility- this @biorxivpreprint & tweetorial are for you! TL:DR- we made primary human T cells better cancer killers!
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RT @DouglasYaoDY: A general thread on what Perturb-seq is, what it's good for, and how we managed to reduce its cost by an order of magnitu….
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RT @BizarMd: Nothing better than two groups independently making pretty much precisely the same observation! Congrats @r_mezzadra @Schumach….
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RT @r_mezzadra: Happy to share our latest paper! Was such a pleasure to help finalizing this work, which Chong and I started long time ago….
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RT @Cancer_Cell: Online Now: The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
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Very happy to see our study from the @BizarMd lab at @columbiacancer published in Cancer Cell today! Thanks and congrats to @triciahoho, @meri_rogava and the whole team. Link to pdf:
My first first-author pub is finally out in @Cancer_Cell! Endless thanks to @BizarMd @JCA_Melms and @meri_rogava for all their guidance scientifically and personally that made this happen. Tweetorial below from our pre-print for now!
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RT @caseyager: New Treg story out today in @Cancer_Cell! A true team effort with (Twitterless) co-authors Aleks and Mikko from @califano_la….
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Thank you very much @JRNLclub for the opportunity to present our work on treatment-naive melanoma brain metastases. Work done at the @BizarMd lab at @Columbia together with my colleague @_janabiermann and amazing collaborators.
.@JCA_Melms discusses the treatment-naive ecosystem of human melanoma brain metastasis and presents how these differ from extra-cranial metastases. @CellCellPress @_janabiermann @BizarMD @ColumbiaCancer @ColumbiaMed #JRNLclub
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