Yang I Li
@yang_i_li
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Human genomics, gene regulation, RNA. Associate Professor @UChicago.
Chicago, IL
Joined January 2013
RT @jkpritch: Staff scientist position (computational):. I am looking for a computational scientist to join my genomics lab at Stanford. Th….
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RT @XuanyaoLiu: Excited to share our new preprint! CACTI boosts cQTL(or caQTL) discovery by leveraging correlation between nearby peaks, un….
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Happy to share our update to LeafCutter, which allows the study of unproductive splicing from short-read RNA-seq. We report findings from analysis of 3 large datasets (GTEx, multi-tissue development in 7 species, Alzheimer brains from AD FunGen consortium). See thread by Carlos.
We are excited to share our new preprint on LeafCutter2! Our new method clusters, quantifies, and classifies splice junctions and intron clusters according to their molecular functionality (e.g., protein-coding or NMD-splicing). @yang_i_li .
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RT @ItaiYanai: Science’s secret weapon is that it cannot be subject to authority. There is no hierarchy when making discoveries which only….
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RT @SStevenWang: My Chinese American colleagues in Texas public universities such as the whole U Texas including MD Anderson are now requir….
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Super thrilled to see @ZepengMu's work out in preprint form! See thread for summary of his thorough mapping and analysis of caQTLs from PBMC scATAC-seq data.
Excited to share the final chapter my PhD research on @medrxivpreprint! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci.
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RT @XuanyaoLiu: Our work is out in AJHG! I wholeheartedly thank all the co-authors @marie_saitou @andywdahl @qbw_128 for their time and eff….
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RT @JinghuiLi14637: I am very excited to share my study, trans-regulation of proteome through protein-protein interactions, at #ASHG2024 !….
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RT @fei_jingyi: Looking for postdoc candidate, who is interested in RNA-protein interactions, RNA localization and gene regulation. Candida….
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RT @XuanyaoLiu: We found that proteins with trans-pQTLs but without cis-pQTLs are under much stronger selective constraints than those wit….
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RT @XuanyaoLiu: 🚨New Preprint Alert: Our work led by @JinghuiLi14637 is up on bioRxiv. We re-analyzed large maps of trans-pQTLs, and found….
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RT @jkpritch: Two new chapters from my free online book in human genetics out this weekend!. These complete Part 3 of the book, on human po….
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RT @jakphd: Really impressive paper from @skoyamamd, @pnatarajanmd, and co. looking at rare exome variants in 1.15M (MVP, UKB, AoU) individ….
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RT @LabWaggoner: "stay curious and excited about science, especially about what’s happening outside your field. You never know where your n….
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RT @slavov_n: Changes in RNA abundance are most often attributed solely to changes in RNA production (transcription). Remember RNA degrada….
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RT @SikaZheng: @yang_i_li @BenjaminFair3 @cfbuenabad very interesting. Our 10y effort (though very low throughput) of characterizing many i….
nature.com
Nature Communications - The genetic control underlying axon formation in neurons is unknown. Here, the authors report that neural-specific induction of TRIM46, one of the earliest axonal markers,...
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Very useful resource for validating methods for predicting mutational effects on splicing. Looking forward to using this in our next project!.
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RT @PatSullivann: We’re thrilled to announce the publication of SpliceVarDB: A comprehensive database of experimentally validated human spl….
cell.com
Predicting whether a genetic variant will affect mRNA splicing is challenging. With SpliceVarDB we have consolidated and harmonized experimental splicing evidence for over 50,000 genetic variants...
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