
Will Hooper
@willbfx
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bioinformatics scientist @nygenome — all opinions my own
NYC
Joined January 2021
NEW: Hotels and motels have quietly become New York’s most common solution for emergency shelter for homeless people outside NYC. Many stay in dilapidated rooms without the social services that shelters are required to provide. https://t.co/YdEHZn2157
nysfocus.com
Statewide spending on hotels has more than tripled in recent years. The shift away from shelters has prevented families from accessing services like child…
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Grateful for the opportunity to present our CLONEVO investigator-initiated trial (IIT) in bladder cancer at @ASCO #ASCO2025. Here are some lessons I learned along the way: Investigator-initiated trials (IITs) are essential. IITs are clinical trials independently designed and led
Live at #ASCO25: Dr. Bishoy Faltas (@FaltasLab) presented results from the CLONEVO #ClinicalTrial for #BladderCancer that he led with other @WeillCornell #GU team members https://t.co/55Dk6gZWgc
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Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇
What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau_lab Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! https://t.co/ZMaJqUKNDK
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Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graph https://t.co/9wzvlfJgC5
#biorxiv_bioinfo
biorxiv.org
Here, we present Lancet2, an open-source somatic variant caller designed to improve detection of small variants in short-read sequencing data. Lancet2 introduces significant enhancements, including:...
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Good time to read our Tweetorial/ X-planation of our https://t.co/sU6uF9rfGa paper now featured on the cover of @Nature!
🚀Big News! Excited to share our work “The Interplay of Mutagenesis and ecDNA Shapes Urothelial Cancer Evolution” published in @Nature! https://t.co/sU6uF9rNvI
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🚀Big News! Excited to share our work “The Interplay of Mutagenesis and ecDNA Shapes Urothelial Cancer Evolution” published in @Nature! https://t.co/sU6uF9rNvI
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"Did you know that you don't need targeted panels for ultra-sensitive MRD?" 🥳 Down right ebullient to share our latest 🥳@NatureMedicine ! MRD-EDGE leverages advanced #ML for #WGS #ctDNA detection across clinical context https://t.co/drJasWVwoE
#DeepLearning 🪡
nature.com
Nature Medicine - Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables...
some #GoldenGlobes tea😭😭 “i asked for a picture with him and she (kylie jenner) said no” – selena gomez “with timothee?” *selena nods*
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Human cancer is a disease of somatic mutations. As we age, tissues accumulate errors in DNA, but what causes mutations in young healthy cells? Read our new paper “Childhood cancer mutagenesis caused by transposase-derived PGBD5” https://t.co/B3RKAtYIWd 1/n
science.org
Induction of somatic oncogenic mutations by the domesticated transposase-derived gene PGBD5 promotes medulloblastoma development.
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We (@nygenome cancer compbio group) are very fortunate to work closely with @WCMEnglanderIPM and have several papers in preparation. Here is one focused on brain metastases in prostate cancer with @FKhaniPath @willbfx @mishabeltran
https://t.co/v7rT6XQV3v
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I like very much this work from @FaltasLab in bladder cancer. It is innovative and an example of tumor evolution. It builds on what we know from #TracerX with @CharlesSwanton’ group. Bravo Bishoy! @OncoAlert @Cornell @DanaFarber_GU @OncoBellmunt @CharleneMantia @bergsa83
Pre-print alert 🚨Excited to share our new preprint “The interplay between mutagenesis and extrachromosomal DNA shapes urothelial cancer evolution” 🧬🔬#bladdercancer
https://t.co/lDZf36CpB9
@OncoAlert
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Pre-print alert 🚨Excited to share our new preprint “The interplay between mutagenesis and extrachromosomal DNA shapes urothelial cancer evolution” 🧬🔬#bladdercancer
https://t.co/lDZf36CpB9
@OncoAlert
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[job] Join my group! Bioinformatics Analyst, Computational Biology @nygenome.
jobs.silkroad.com
Find a career with New York Genome Center
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NY Genome Center Team Harnesses Ultima Genomics Platform for High-Sensitivity ctDNA Sequencing. Taking advantage of the new platform’s low sequencing cost, the researchers sequenced cell-free circulating DNA (ccfDNA) in plasma at high depth for...
genomeweb.com
Taking advantage of the new platform's low sequencing cost, the researchers sequenced cell-free circulating DNA (ccfDNA) in plasma at high depth for sensitive cancer monitoring.
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🔥Extra-hot pre-print before this hellsite goes up in smoke 🔥 New horizons open up when sequencing costs go ↘️ @UltimaGenomics Interested in deep cfDNA WGS for ultra-sensitive cancer detection? Duplex sequencing at genome scale? https://t.co/DJeCo86ok8 Check out 🪡👇
biorxiv.org
Circulating cell-free DNA (ccfDNA) sequencing for low-burden cancer monitoring is limited by sparsity of circulating tumor DNA (ctDNA), the abundance of genomic material within a plasma sample, and...
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Read our latest on the causes of oncogenic DNA rearrangements in medulloblastomas, a common childhood brain tumor: Childhood cancer mutagenesis caused by a domesticated DNA transposase
biorxiv.org
Genomic rearrangements are a hallmark of most solid tumors, including medulloblastoma, one of the most common brain tumors in children. Childhood cancers involve dysregulated cell development, but...
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"Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence", new #OpenAccess article from at @WUSTLmed, @EmmesCRO, and @SylvesterCancer (@univmiami). Full FREE article:
jmdjournal.org
The U2AF1 gene is a core part of mRNA splicing machinery and frequently contains somatic mutations that contribute to oncogenesis in myelodysplastic syndrome, acute myeloid leukemia, and other...
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🎶It's raining pre-prints, hallelujah! 🎶 Delighted to share our next generation of ctDNA detection through whole genome mutational aggregation 👉MRD-EDGE 👈 With advanced machine learning signal enrichment we went further and deeper than ever before! https://t.co/0TZFDia4Zc
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