Type VI Sophia System
@wheezenfeld
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mother of disease • former vibrio • microbiome truther • she/her • GT’21 🐝, @HMS_SysBio PhD any%
Joined January 2020
I’ll never understand why people live in cities when options exist
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The project has excellent lore. From contamination to a integrated tool to classify mobility, A-Dog (Arya to civilians) has found AMR gene have been increasing on MGEs likely due to the use of antibiotics. Some great graphs in here!
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at genomes from the NCTC historical collection now out in : https://t.co/cjMd33gNMU
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This is one of the findings that really motivates my research: yes, antibiotic resistance genes are ancient, but the age of antibiotics has likely contributed to a big change in their mobility and of the landscape of MGEs we see today! Very happy for Arya & to see this published.
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at genomes from the NCTC historical collection now out in : https://t.co/cjMd33gNMU
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Llama dolphin is bioweapon
Llamas, dolphins and measles? Oh my! So thankful this story is finally breaking containment from my time in the @MangusoLab. Using pieces from viruses and llamas we engineered selective cell specific viral like particles with reduced immunogenicity for in vivo gene delivery
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Easter eggs from this paper over on bsky, come on over to see 🤲
So happy that I can finally share the results of my first postdoc paper with @baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)
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Thankful to have been given the opportunity to present my wacky little project at @crisprmeeting and grateful for the support from @baym @fernpizza and the rest of the lab!
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Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! https://t.co/k04NdEUvss 1/
biorxiv.org
Phages interact with many components of bacterial physiology from the surface to the cytoplasm. Although there are methods to determine the receptors and intracellular systems a specified phage...
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Excited to share a new preprint led by Indra Gonzalez Ojeda on a new tool to improve pangenome calling in bacteria, CLARC. https://t.co/BAnSAaFf26 . Passing output of Roary for S. pneumoniae populations through this tool reduces accessory genome > 30%, resolves other puzzles
biorxiv.org
Bacterial genomes exhibit significant variation in gene content and sequence identity. Pangenome analyses explore this diversity by classifying genes into core and accessory clusters of orthologous...
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Hey, it worked for me too. That is an interesting ripple on the pond of knowledge I hadn't anticipated (talking about @skryazhi's recent super cool paper)
Being in the training data is useful. A few of the LLMs do a good “explain this like Ethan Mollick” - not nearly as good as me (in my opinion) - but kind of neat to see a form of intellectual legacy happen in real time.
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My lab is up and running and just needs enthusiastic phage biologists to populate it! Contact me or apply in the link if you are interested in a postdoc exploring plasmid-dependent phage biology in beautiful (and super affordable!) upstate New York🍎 https://t.co/nYWsBgNih4 1/3
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Come see Amy at poster 174 & learn about how active prophages may change the trajectory & evolution of resistance to DNA damaging antibiotics 💊 ⚡️ #EMBOEvoEco
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The bioRxiv version highlighted how anti-defense genes in plasmids are concentrated in the leading region under specialized ssDNA promoters ( https://t.co/Ot8T8DQuzR). In our new @Nature paper, we delve deeper and add experimental evidence. ✨Let's explore what's new! 2/7
Imagine you’re a plasmid conjugating into a recipient cell. How would you overcome CRISPR-Cas and other bacterial defense systems? Encoding anti-defense mechanisms is one obvious way. But where? And how? @BruriaSamuel set out to explore! 🧵 1/6 https://t.co/dsf3U0bsjs
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i’m alive! i’m in my flop era but my flop era lowkey serves
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dusting off the ol twitter account to tweet at EMBO molecular mechanisms next week 🙇♀️
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Stop by poster 72 to hear my emotional support Shreyas talk about coevolution of 2 types of mobile genetic elements 👀 💪 #bbm2024 @TheShreyasPai
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come see my poster and test your night vision in one fell swoop at #bbm2024 #lightsout #anotherdayanotherslay
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stable limit cycles
for once, i’d just like to spiral into control.
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Boston microbiologists pull up 💯 If anyones at the Microbial Sciences Initiative (MSI) come say hello!!🙂↕️
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