Vali Barsan, MD 🇺🇸
@vbarsan
Followers
564
Following
1K
Media
23
Statuses
2K
MedGemma 1.5 is a major upgrade to our open models for healthcare developers. The new 4B model enables developers to build applications that natively interpret full 3D scans (CTs, MRIs) with high efficiency - a first, we believe, for an open medical generalist model. MedGemma
169
662
6K
Excited to announce the Cancer Research Institute Discovery Engine — a groundbreaking open, AI-enabled database poised to accelerate cancer immunotherapy Capturing drug-immune-tumor interactions with single-cell + spatial resolution across models and patients. Including drug
Launched at #JPM2026: the CRI Discovery Engine, a first-of-its-kind foundational database for cancer immunotherapy. In collaboration w/ @10XGenomics, @StanfordMed, @PennMedicine + @MSKCancerCenter this initiative inaugurates a new chapter in immunotherapy:
3
12
97
Can we design mutations that predictably bias proteins towards desired conformational states? Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify
13
192
828
Predicting cell state in previously unseen conditions such as disease or in response to a drug has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly
30
206
939
The new year marks a new era: Somite is now Cellular Intelligence. This is a statement of what we are building: the first universal virtual cell signaling-model to understand, predict, and control cell behavior. To mark this moment, we’re releasing a white paper sharing
2
28
108
We need more rugged individualism, not less. Build on the frontier. Be independent. Decentralize power. Accelerate civilizational progress. Celebrate economic freedom.
914
1K
12K
Venezuela used to be twice as wealthy as Chile. Then Chile adopted free-market principles while Venezuela chose socialism. Now Chile is the wealthiest large country in South America and Venezuela the poorest. Free markets work, socialism makes nations poor.
460
5K
15K
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection https://t.co/p4OXzMT8oU
https://t.co/DuBlj1RPBw
nature.com
Nature Biotechnology - Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.
1
55
118
Neuralink will start high-volume production of brain-computer interface devices and move to a streamlined, almost entirely automated surgical procedure in 2026. Device threads will go through the dura, without the need to remove it. This is a big deal.
NEURALINK 2025: - Received FDA Breakthrough Device Designation for its speech restoration technology targeting severe speech impairments. - Launched its first clinical trial in the Middle East (UAE-PRIME) at Cleveland Clinic Abu Dhabi in partnership with the Department of
4K
7K
59K
US: We need to use AI to design molecules faster. China: We can brute force any target designed, into clinic, and sold to big pharma faster than you can clear an IND.
9
12
216
Insightful read on how @BridgeBioPharma pursues genetic diseases, utilizing the predictability of genetic science as a financial instrument to lower the Cost of Capital (WACC) thus maximize Quality-Adjusted Life Years (QALYs) per dollar invested. https://t.co/GixamX5hJy
0
0
0
MUST READ from the WSJ: “Something is profoundly wrong with the U.S. welfare system—a problem that runs far deeper and is more dangerous than the shocking fraud in Minnesota that has been making headlines… real federal welfare spending has soared by 765%, more than twice as fast
2K
9K
28K
On Wednesday evening, a monumental pediatric cancer bill made it to the Senate floor—the last hurdle before passage. Cancer victims watched in the gallery. Sibling survivors too. And then... it failed. Because of one vote. Bernie Sanders'. Here's why. https://t.co/j6zfxvJxTm
thebulwark.com
The Vermont senator is holding out for a bigger health care package. Advocates are asking: Is the price worth it?
38
57
212
My CISO called me at 3 AM last Tuesday. "We caught someone." I asked, "Caught them doing what?" He said, "Typing." Let me explain. We have an employee in IT. Great worker. Always online. Never complained. Perfect Slack etiquette. One problem. His keystrokes were arriving
646
4K
19K
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction. ctDNA kinetics reveal insights into the timing, risk, and anatomical pattern of relapses —> adaptive treatment recommendations in early stage NSCLC
cell.com
Longitudinal ultrasensitive ctDNA detection improves disease stratification accuracy, demonstrates clinical utility for adjuvant therapy, and reveals insights into characteristic features of relapse...
0
0
0
"The most important thing in the next 3-4 years is data centers in space. In every way, data centers in space, from a first principles perspective, are superior to data centers on earth. In space, you can keep a satellite in the sun 24 hours a day. The sun is 30% more intense,
This is my fifth conversation with @GavinSBaker. Gavin understands semiconductors and AI as well as anyone I know and has a gift for making sense of the industry's complexity and nuance. We discuss: - Nvidia vs Google (GPUs + TPUs) - Scaling laws and reasoning models - The
872
2K
10K
T cell engagers have demonstrated efficacy in 'cold' tumors, but where do the T cells come from? and how can we improve response? With @SageJulien and Chris Garcia, we show that TCEs recruit new T cell clones to the tumor, ala PD-1 blockade, and can be improved with cytokine
Bispecific T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells https://t.co/2OYpAgNgGk
#biorxiv_cancer
1
26
131