Wai-Hong Tham
@tham_lab
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๐ฒ๐พ scientist in ๐ฆ๐บ | ๐ฆ ๐ฉธ #malaria |๐ฆ #nanobodies | Prof @WEHI_research @ourANU | on Wurundjeri, Ngunnawal & Ngambri lands | views my own ๐๐ปโโ๏ธ ๐
Joined May 2018
We are making antibody cocktails against #COVID19 !! ๐ #MRFF funding to manufacture monoclonal antibody treatments into clinical trials. Great collaborative outcomes between @WEHI_research @TheDohertyInst @BurnetInstitute @KirbyInstitute @CSL AffinityBio and @CSIRO
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Keen to use an open source workflow for nanobody discovery? Check out Alpseq ๐ฆ Alpseqโs diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection Great collab @QGouil & Kathleen Zeglinski @WEHI_research
https://t.co/diR6qzP3pY
biorxiv.org
Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables...
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Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens
https://t.co/khGAl0PRV3 Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.
journals.plos.org
Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available...
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Learn how our hunt for the native structure of top #antimalarial target PfATP4๐งled to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms ๐ https://t.co/SX5vBW1ZzT ๐ฆ ๐ฌโ๏ธ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
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Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. ๐งต
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In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel โpredictorโ prizes, I think that these 36 scientists are the most likely candidates:
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Delighted to talk about blocking malaria transmission at Directorโs Seminar @JCSMR ๐ฆ๐ฆ๐ฆ Fun to discuss cryo-EM structures, nanobodies, new bispecifics and mRNA vaccines that block transmission๐ฌ ๐ ๐ ๐@MeganOutram91 for taking the first ever photo where you can see me ๐
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Step inside the world of discovery, where imagination and creativity collide, with our online gallery #ArtofScience. View 16 extraordinary images captured by WEHI scientists workingย to solve urgent health challenges. See the exhibition: https://t.co/o2kEZ1wZDi
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Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. https://t.co/hGGnAnjqlI
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Frankie Lyons PhD Completion Seminar ๐ She worked on key fertilisation antigens for malaria parasites - Pfs48/45 and PfHAP2 - developing nanobodies, bispecifics & mRNA vaccines to block malaria transmission ๐ฆ @WEHI_research ๐ฑ Lab support wearing her favourite moss green
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๐ Applications are now open for WEHIโs International PhD Scholar Initiative. ๐
Apply by Sunday 26 October 2025 ๐ Learn more about eligibility, scholarships and how to apply: https://t.co/c32y0Hth1t Help us spread the word by sharing with your networks!
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Like to take 12โ24 months of fully supported research in Japan? Early-career Australian researchers can apply for the 2026โ27 JSPS Postdoctoral Fellowships to undertake 12โ24 months of collaborative research in Japan. This prestigious program offers generous support, including
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๐จ Weโre hiring! Join @SAiGENCI in Adelaide as a Structural Biologist in my lab ๐งฌ๐ฌ Use cryo-EM & biochemistry to unravel chromatin-associated complexes. ๐ฐ $102kโ$135k ๐ World-class facilities + Titan Krios access https://t.co/7z6ImKcLQ4
#cryoEM #structuralbiology #chromatin
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Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! ๐ Free access reprint link found here: https://t.co/xfeRbYbyGj ๐ฑclick on ๐ and last link ๐ป last link on the left hand side #malaria #transmission #cryoEM #ScienceResearch
https://t.co/zDlqTm5RIz
science.org
Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and...
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Discovery: mRNA vaccine candidate blocks malaria from reproducing inside mosquitoes, cuts transmission by up to 99.7%. Built on cryo-EM insights into parasiteโs fertilisation machinery. A key step towards elimination. In @ScienceMagazine ๐ https://t.co/fopeMEP7Gq
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The chemosensory world of #mosquitoes: olfactory receptors and their role in blocking #mosquito-borne disease transmission https://t.co/2TXdhsB9ad Parasites&Vectors
parasitesandvectors.biomedcentral.com
Mosquitoes are vectors for a variety of infectious diseases, which pose a significant threat to human health, public well-being, and national security. The increasing prevalence of insecticide...
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Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex | Science
science.org
Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and...
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Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! ๐ ๐ฆ Transgenic parasites without Pfs230 D13D14 do not transmit ๐ฆ ๐Nanobodies + mRNA induced antibodies reduce transmission New in @ScienceMagazine
https://t.co/zDlqTm5jT1
#ScienceResearch #Malaria
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NEWS: Professor Ana Domingos (@OxfordDPAG) and Professor Matt Higgins (@BiochemOxford) have been elected to the EMBO Membership in recognition of their outstanding achievements. Congratulations! ๐ https://t.co/P6sKnsRATW
medsci.ox.ac.uk
Two University of Oxford academics have become the latest to join the eminent life scientists in Europe and beyond that make up the European Molecular Biology Organization (EMBO).
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