Target 2035
@target2035
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🌍 open science movement to develop by 2035 pharmacological tools for all human proteins; https://t.co/7QqI6Xb48s & https://t.co/SR2W97oLbs
Worldwide
Joined August 2021
#MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us:
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#MAINFRAME is an #OpenScience Network, supported by Target2035 & ultra-large-scale experimental screening data, brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks tackling #DrugDiscovery challenges. https://t.co/TRk15sZ7Lz
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New episode for our Target 2035 Podcast Series 🎧 @MilkaKostic talks with @aledmedwards to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here: https://t.co/JUI5VWMQ79
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A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK. https://t.co/fg3lyssOpf
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A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease. https://t.co/5P4SAMcmOy
pubs.acs.org
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in...
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🚨 New publication alert! 🚨 Our latest update on the Chemical Probes Portal is live! 🎉 📜 Read the paper: https://t.co/idifAiYU4t 🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue. #ChemicalProbes #BiomedicalResearch
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📢RSC Medicinal Chemistry is delighted to announce our newest Associate Editor, Dr Susanne Müller-Knapp from @goetheuni! 📰Read our blog for more about Susanne: https://t.co/2BhTY2Q4a7 👀Submit to her today: https://t.co/qoVUSK7Fxz
@Chemical_probes @thesgconline
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Just Launched! Episode 1 of the Target 2035 Podcast Series🎧 In the debut episode, @LabScribbles welcomes @CherylArrowsmi1, a leading scientist in chemical biology and one of the initiators of Target 2035. https://t.co/CAChqSQKrU
#Target2035 #OpenScience #DrugDiscovery
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🎙️ The Target 2035 podcast series is officially LIVE! In our pilot episode, meet our hosts - @MilkaKostic, @LabScribbles and Opher Gileadi who share their personal motivations for joining the Target 2035 initiative. Tune in to the pilot episode now! https://t.co/HVvdc6mLkb 🎧
creators.spotify.com
Hello, listeners! In this pilot episode of our Target 2035 podcast series you will meet our incredible hosts - Rachel Harding, Opher Gileadi and Milka Kostic - as they give you an overview of what...
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🎙️ Get ready... Something BIG is coming from Target 2035! What if the future of drug discovery could be unlocked by listening in? @LabScribbles, @MilkaKostic and Opher Gileadi got something brewing, and trust us- you won’t want to miss it! #Target2035, #OpenScience, #ComingSoon
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The short history of NSD2 degraders has been a little fuzzy with some odd mechanisms of action so far, but this one seems a little cleaner and more potent than its forebears. https://t.co/WgHOfce62m
pubs.acs.org
Nuclear receptor-binding SET domain-containing 2 (NSD2), a methyltransferase that primarily installs the dimethyl mark on lysine 36 of histone 3 (H3K36me2), has been recognized as a promising...
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This is a terrific and comprehensive review on molecular glues from the Arkin lab. Open access too. https://t.co/dpbKFpNkpC
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Our ASMS platform is now officially up and running! @HalabelianLab and Hui Peng, with the support of the @InnovationCA, have completed the first round of ASMS screenings for 8 proteins in just 2 weeks, including thorough hit verification. Stay tuned for more exciting data!
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Nice work from Gray and @fischerlab1 labs on combinatorial libraries for CRBN molecular glue discovery that yielded a WEE1 degrader.
biorxiv.org
Small molecules promoting protein-protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like structures and ability...
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Wow!! Congratulations @BShoichet and others.
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Need a #chemicalprobe? @chemical_probes has reached 1000 chemical tools that have been reviewed by #drugdiscovery experts.
Kudos to @Chemical_probes for reaching 1,000 compounds! A great collaboration with @target2035 to expedite chemical probe discovery.
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#AstraZeneca publishes on the challenges and impact on developing #highthroughput #thermalshift based #drugdiscovery High-throughput differential scanning fluorimetry (DSF) and cellular t...
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Stefan Knapp and Susanne Muller talk about how different stakeholders can contribute to high-quality research using small molecule tools. https://t.co/y2JvXBnEff
nature.com
Nature Chemical Biology - The quality of chemical tools and their appropriate use determine the quality and reliability of scientific data based on their use. Now, two papers extend criteria to new...
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We are happy to share that @target2035 will be featured in the upcoming @ChemBioSociety 2023 with a scientific session chaired by @CherylArrowsmi1. Among the speakers will be our very own @mattschap and Serah Kimani from @HalabelianLab. More details:
🔬 Join us at #ICBS2023 for a special scientific session featuring @target2035, a global open science movement with to develop a modulator for every protein in the human proteome by 2035. Sponsored by @EUbOPEN. More details: https://t.co/VH0wCzxleh
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A recent review by Edelris and AstraZeneca on "Affinity selection mass spectrometry speeding drug discovery"
pubmed.ncbi.nlm.nih.gov
Affinity selection mass spectrometry (AS-MS) has gained momentum in drug discovery. This review summarizes how this technology has slowly risen as a new paradigm in hit identification and its...
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