Parker Singleton
@singletonion
Followers
2K
Following
7K
Media
649
Statuses
4K
dad - senior scientist at https://t.co/yahvMgGrLa - psychedelics and other fun stuff - aspiring urban homesteader - https://t.co/CaARmkGGQn
Greenville, SC
Joined March 2018
đ Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it đ§”
4
17
72
A new pre-print from my lab + colleagues. Defining âpsychedelicâ https://t.co/cb0pycWNZB via @OsfFramework
osf.io
Humphry Osmond coined the term âpsychedelicâ in 1956, conjoining âpsycheâ for âsoulâ and âdelicâ from âdĂȘlosâ for âto manifestâ or âilluminate.â Soul-illumination is an adjective that describes a...
3
9
44
New paper with @eselster â Why do people believe in a flat earth, pseudoscience, or supernatural entities? Prevailing approaches point to psychological biases (like agency detection) or social dynamics (like signaling). Our claim: experience matters, too! @TrendsCognSci
Why do humans believe in things that seem to lack all supporting evidence, like conspiracy theories, spirits and psuedoscience? In a new Review for @TrendsCognSci , @mnvrsngh and I argue that experience plays a crucial role in shaping these 'extraordinary beliefs.' Link in đ§”
2
20
126
Psilocybin research seems on slope of enlightenment: -large trials w/ active controls -multi-site replications -meta-analyses on risks/benefits Ibogaine seems it's cresting the peak of the hype cycle: -small uncontrolled studies -anecdotes outpacing evidence -understudied risks
Is the psychedelic hype bubble about to burst? Might that be best for the field? In a new @JAMAPsych article w/ me, @jpotash1, & R. Griffiths, we argue for moving beyond overly negative AND positive extremes to embrace the actual evidence @JHPsychedelics
https://t.co/LnkkUMO0tj
1
4
23
On the second anniversary of Roland Griffiths' death, I'm taking the opportunity to reflect on the value of scientific curiosity and the virtue of constant curiosity about life in general that he seemed to me to so consistently embody.
It's been a week since my advisor, colleague, & friend Roland Griffiths passed away. Even though it was expected, his death still came as a shock and I've been trying to find the right words. I wrote this to honor one of his exceptional qualities--his spirit of radical curiosity:
0
4
17
one of the coolest works I've ever had the joy of being a part of! hats off to Parker on this thought-provoking piece.
In the Allostatic Triage Model of Psychopathology (ATP Model), we propose a novel concept: Allostatic Triage: the stress-induced redistribution of energy from CNS networks optimizing long-term outcomes to those supporting short-term survival.
0
1
5
đš New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. đ𧔠https://t.co/x3KbEcEawP
#Neuroscience #Psychedelics #BrainImaging
1
26
59
How does energy keep us alive? Our bodies are resistive energetic circuits where electrons flow from foodâoxygen in our mitochondria. It's only through energy resistance (Ă©R) - like electrical resistance - that transformation of energy into life is possible. The Energy
34
223
876
New @ImagingNeurosci from @BrandonTaraku: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression
direct.mit.edu
Abstract. Ketamine produces fast-acting antidepressant effects in treatment-resistant depression (TRD). Prior studies have shown altered functional dynamics between brain networks in major depressi...
0
7
19
Interested in the mechanisms shaping the extraordinary complexity of the connectome? Then check out our new preprint, lead by @_francisnormand with a stellar team showing how geometry constrains connectome architecture: https://t.co/xKWm5R6x3N Peep the đ§”
2
24
37
"We are not anti-psychedelics; we just want historical accuracy." Psychedelics, Eleusis, and the Invention of Religious Experience https://t.co/ny2ABleJBb
liebertpub.com
Introduction: This article corrects an idea in psychedelic science and culture that the ancient Eleusynian Mysteries used psychedelics, as claimed by Carl Ruck and co-authors in The Road to Eleusis:...
2
1
13
Musical Chess teaches toddlers and big kids with hands-on fun
greenvilleonline.com
Musical Chess is a new Greenville program that teaches chess to children ages 2œ to 7.
1
2
1
Today is publication day for my book, Shamanism: The Timeless Religion. To celebrate, here are some of my striking clips of shamanic rituals that I came across while working on the book:
15
163
826
Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder
jamanetwork.com
This randomized clinical trial assesses the dose-response relationship of MM120 (lysergide D-tartrate) vs placebo in adults with moderate to severe generalized anxiety disorder.
4
5
36
@RCarhartHarris Is this one of the two or three? https://t.co/9pjaZ20156 "Mindset prior to dosing, and spiritual experiences and perceptual shifts during dosing were identified as possible predictors of treatment trajectory [...] while treatment expectations did not influence outcomes."
academic.oup.com
AbstractBackground. Depressive disorders are a major global health challenge, with many individuals unresponsive to existing treatments or left with residu
0
1
8
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" https://t.co/oVTCtzluGj
researchsquare.com
We investigate the spatiotemporal organization of resting-state brain activity in individuals with and without major depressive disorder (MDD), identifying stable and recurring whole-brain functional...
0
0
3
Claustrum!
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum https://t.co/Hnctpb6tUf
0
0
8
đŁ Weâre recruiting 1-2 postdocs to the incredible WBHI team to lead projects mapping brain & behavâl changes across major endocrine transitionsâfrom adolesc to pregnancy to menopause. Expertise in MRI & human subjects necc. Please reach out to info@wbhi.ucsb.edu đ
2
24
41
Brooke Sevchik, Analiese Lahey, Pim Cuijpers, @MathiasHarrer, Megan Jones, @sdpnayak, Eric Strain, @VandyAtVandy, Bob Dworkin, Cobb Scott, and @sattertt
0
0
0
All of this and more can be easily accessed through https://t.co/ICdlySqJJl Team effort with co-first author Brooke Sevchik and the rest of the SYPRES and metapsy teams. https://t.co/GgeyqkzWRE
medrxiv.org
Importance Depression is a major cause of disability worldwide, motivating substantial interest in psilocybin as a potential treatment. Objective To conduct a systematic review and meta-analysis of...
1
0
3