D. Parker Kelley
@sequencemyneuro
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@TrPR_program, @thethrivelab UCSF/SFVA, Mitochondrial Psychobiology/Bioenergetics, Psychoneuroimmuno, Psychedelics @sequencemyneuro.bsky.social
Joined October 2019
Huge Co-1st/Corresponding author paper just published in @JAMAPsych ! I just can't thank our team enough for their unwavering support on this project. Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials https://t.co/oHsdtQ58fK
jamanetwork.com
This narrative review describes clinical trials of psychedelic or MDMA therapy and reports from the investigators on the use of modifications to informed consent in these studies.
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You asked, we’re back! As we begin to see the body as an energy-transforming system & not just a sum of it's biomolecules, new questions emerge: Can mapping resistive energy circuits reveal how & when we move away from optimal health? What does it take to restore it?
By popular demand, there will be an Energy-ERP Part 2. In this discussion we will focus on an energy-based understanding of diabetes and insulin resistance. With @msahsorin Link to register: https://t.co/SlsMsf1U2d
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Thank you @trikomes for the great discussion on linking physical principles to physiology through our the ERP.
New episode with @MitoPsychoBio & @msahsorin: “Energy Resistance Principle in Life, Healing & Disease”
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Lykos has stopped spending on federal lobbying, while Compass Pathways has more than doubled its allocation. The Association for Prescription Psychedelics also began spending money on lobbyists.
Q3’25 Psychedelic Lobbying Update Here, we share our analysis of the latest developments in federal psychedelics lobbying for our Pα+ subscribers. Here’s a review of Q3 2025 activity… https://t.co/P5tWRoiwF6
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Great readable summary of the many functions of mitochondria and how they relate to different facets of our health. Thank you, @EmanuelRosen!
Our book on mitochondria, “The Life Machines,” is now available from Simon & Schuster in hardcover, eBook, or audiobook. An idea we had four years ago came to life! Is there a link between healthy aging and mitochondria? What can we do to take care of these tiny organelles in our
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In 2014 i asked my biological basis of psych professor why some people are more likely to hold onto negative energy. The ATP model is @sequencemyneuro and I digging deep to show him that the term "energy" in regards to psychology isn't meaningless.
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The big question here is why Midazolam showed such large antidepressant effects, especially with twice-weekly admins? It was used as a + control for the subjective effects of ket, not for the AD effects- its not an anti-depressant, and AFAIK, this has not been previously observed
🚨 Is ketamine effective for treating depression when tested in a trial that actually controls for confounders? You be the judge: » 3 point difference on MADRS vs control » MADRS is a 60 point scale How to reconcile this landmark study published yesterday in JAMA Psych 🧵
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For those of us interested in what’s missing in our understanding of health (how our body stores, transmits, & transforms information across scales & time) it’s worth revisiting one of the most beautiful thought experiments in physics: Maxwell’s Demon. It inspired a simple but
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I have an intuition that mitochondria are quantum entanglement machines
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Perhaps a simple shift in the way we speak and think can make big differences in how we feel, and how our bodies function in the world. Should we rethink the language we use to describe our "work"?
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Language impacts mood & @MitoPsychoBio & co. showed that nighttime positive mood is associated with mitochondrial energy transformation capacity (MHI) in peripheral immune cells, showing that mitochondria respond to prior mood states. https://t.co/pGN1OXu5YK…
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Alan Watts rejected the strict separation between work and play/ leisure & often remarked that one can engage in any activity with a playful attitude. He argued that engaging in even the worst drudgery as a game, with complete presence, is the real secret to a good life.
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IMO this is some of the best work being done in all of experimental biology today, and one of my favorite podcasts ever "Sleep neurons" in the animal brain have built-in mechanisms to keep track of how many lipid peroxidation toxins have been made within the cell. Eventually,
Think about what this means. The reactive (toxic) compounds produced from lipid peroxidation (oxidation of PUFAs from seed oils) is such a clear indicator of cellular stress and the need for recuperation that Nature keeps track of this and uses that metric to decide when to put
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Our comprehensive review explores mitochondrial immune signaling pathways, their therapeutic potential in managing inflammation and chronic diseases, and discusses cutting-edge methodologies for mitochondrial research
A new paradigm in intracellular #immunology: #Mitochondria emerging as leading #immune organelles 👇 https://t.co/v5KmFV7BSC
@EricTopol
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Good point & very important topic. I held two different positions in the grad student association in grad school. Lots of students were struggling with mental health, but in my experience it wasn't that they didn't like the work/ideas- it was a workload/ stress/ environment issue
Too many people start a PhD and end up not enjoying the process. Doing something you don’t enjoy day after day is certainly bad for your mental health.
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Thinking is a byproduct of the brain-body system’s activity. Yes, it is useful in many cases to guide us through the world. But thinking happens more fluidly and naturally when the organism’s energetic state is coherent. Metabolic dysregulation disrupts clear thinking for
@MitoPsychoBio 思考也是为了让身体活下去。我们需要思考才能赚到钱，购买食物、住房、医疗。
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The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro
https://t.co/MzVpB5suZH
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@sequencemyneuro Affect, thought and behavior are subject to the same principle of canalization; perhaps it is a defensive strategy— but canalization refers to the process and effect, one of narrowing.
pubmed.ncbi.nlm.nih.gov
This theoretical article revives a classical bridging construct, canalization, to describe a new model of a general factor of psychopathology. To achieve this, we have distinguished between two types...
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For days, I have been trying to write a tribute to our kind, brilliant friend, collaborator and physician, Dr. Nolan Williams @NolanRyWilliams. This beautiful tribute from the veterans Nolan helped, in the post below, has finally unlocked my broken heart long enough to try to
It is with profound shock, deep sadness, and heartbreak that VETS mourns the loss of Dr. Nolan Williams, a beloved friend, ally, and pioneer whose vision transformed the landscape of care for our nation’s veterans. Nolan was not only a brilliant clinician and relentless
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one of the coolest works I've ever had the joy of being a part of! hats off to Parker on this thought-provoking piece.
In the Allostatic Triage Model of Psychopathology (ATP Model), we propose a novel concept: Allostatic Triage: the stress-induced redistribution of energy from CNS networks optimizing long-term outcomes to those supporting short-term survival.
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Allostatic Triage model of Psychopathology (ATP Model):
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