@Amurtab @UAlberta_Pharm 7) For anyone interested in using PSSI-51 as a tool to manipulate #ketone #metabolism #oxidation for their studies, we are happy to share and please just reach out to myself or @Amurtab.

@Amurtab @UAlberta_Pharm 6) So grateful to all @Amurtab hard work and to our many collaborators who helped this paper happen , but a special shoutout to Dr. Dion Brocks @UAlberta_Pharm , whose lab developed the assay for us to detect/measure PSSI-51 in biological specimens.

@Amurtab @UAlberta_Pharm 5) Indeed, @Amurtab demonstrated that treatment of mice with PSSI-51 inhibited #SCOT activity in several tissues, but not in the #brain, while the overall accumulation of PSSI-51 in brain tissue was reduced when compared to pimozide.

@Amurtab @UAlberta_Pharm 4) Because pimozide and other DPBP have several #CNS related adverse effects, whereas #ketones are a major fuel source for the #brain , PSSI-51 was designed in a manner to reduce its ability to penetrate the #blood_brain_barrier to negate these concerns with a #SCOT inhibitor.

@Amurtab @UAlberta_Pharm 3) Importantly, this new agent, which we have termed PSSI-51, reproduced many of the actions with previous #SCOT inhibitors, including decreasing #ketone #oxidation , while improving #glycemia in #obese mice.

@Amurtab @UAlberta_Pharm 2) which we further extended in previous studies to encompass a wide range of diphenylbutylpiperidine (DPBP) based older generation antipsychotics.

@Amurtab @UAlberta_Pharm 1) In this study we have developed a new #SCOT inhibitor that decreases #ketone #oxidation using knowledge of the pimozide interaction with SCOT.

This will likely be my last thread here as I’m moving over to Bluesky (, but wanted to share exciting work from former PDF @Amurtab @UAlberta_Pharm ;

I cannot articulate in the form it truly deserves how much he has impacted my life, but I know I would not be who I am today, or where I am today, if not for him, which I know extends to many others here at the UofA.

This is a very difficult msg for me to type, but it is with deep sadness that I share news regarding the passing of Dr. Gary Lopaschuk, who was not only my mentor, but a dear friend these past 20 years.

RT @Soc_HrtVasMetab: Our LinkedIn page is now live! . Give us a follow to stay up to date with all things SHVM 2025 and beyond #longlivemet….

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A big CONGRATS to @JordanSFChan , who successfully passed his #CandidacyExam this morning! Really proud seeing how much he has matured as a #scientist since joining the lab May 2021

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RT @BertrandLuc_ky: Check our last review in the special issue of Essays in Biochemistry on AMPK and AMPK-related kinase👉AMPK and O-GlcNAcy….

RT @DanielJDrucker: The SUMMIT trial Tirzepatide for #HeartFailure with Preserved Ejection Fraction in PPL with #Obesity A lower risk of a….

RT @DanielJDrucker: On #WorldDiabetesDay2024 congratulations to Professor Erin Mulvihill @HeartInstitute @OttawaU @uOttawaBMI @CIHR_IRSC t….