John R. Ussher
@JussherLab
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Proud father, loving husband, enthusiastic scientist, Detroit Red Wings & Lions diehard, trekkie/space lover, casual Madden player and Game of Thrones Fanatic
Joined March 2015
@Amurtab @UAlberta_Pharm 7) For anyone interested in using PSSI-51 as a tool to manipulate #ketone #metabolism #oxidation for their studies, we are happy to share and please just reach out to myself or @Amurtab
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@Amurtab @UAlberta_Pharm 6) So grateful to all @Amurtab hard work and to our many collaborators who helped this paper happen , but a special shoutout to Dr. Dion Brocks @UAlberta_Pharm , whose lab developed the assay for us to detect/measure PSSI-51 in biological specimens
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@Amurtab @UAlberta_Pharm 5) Indeed, @Amurtab demonstrated that treatment of mice with PSSI-51 inhibited #SCOT activity in several tissues, but not in the #brain, while the overall accumulation of PSSI-51 in brain tissue was reduced when compared to pimozide
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@Amurtab @UAlberta_Pharm 4) Because pimozide and other DPBP have several #CNS related adverse effects, whereas #ketones are a major fuel source for the #brain , PSSI-51 was designed in a manner to reduce its ability to penetrate the #blood_brain_barrier to negate these concerns with a #SCOT inhibitor
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@Amurtab @UAlberta_Pharm 3) Importantly, this new agent, which we have termed PSSI-51, reproduced many of the actions with previous #SCOT inhibitors, including decreasing #ketone #oxidation , while improving #glycemia in #obese mice
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@Amurtab @UAlberta_Pharm 2) which we further extended in previous studies to encompass a wide range of diphenylbutylpiperidine (DPBP) based older generation antipsychotics https://t.co/tCQ95QNndZ
diabetesjournals.org
Despite significant progress in understanding the pathogenesis of type 2 diabetes (T2D), the condition remains difficult to manage. Hence, new therapeutic
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@Amurtab @UAlberta_Pharm 1) In this study we have developed a new #SCOT inhibitor that decreases #ketone #oxidation using knowledge of the pimozide interaction with SCOT https://t.co/JI34ooRoKH
cell.com
Al Batran et al. demonstrate that the rate-limiting enzyme of ketone oxidation, succinyl CoA:3-ketoacid CoA transferase (SCOT), is elevated in skeletal muscles of diet-induced obese mice. This...
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This will likely be my last thread here as I’m moving over to Bluesky ( https://t.co/WHZdpadTP3), but wanted to share exciting work from former PDF @Amurtab @UAlberta_Pharm ;
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I cannot articulate in the form it truly deserves how much he has impacted my life, but I know I would not be who I am today, or where I am today, if not for him, which I know extends to many others here at the UofA
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This is a very difficult msg for me to type, but it is with deep sadness that I share news regarding the passing of Dr. Gary Lopaschuk, who was not only my mentor, but a dear friend these past 20 years. https://t.co/ichIpbSXzB
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Our LinkedIn page is now live! Give us a follow to stay up to date with all things SHVM 2025 and beyond #longlivemetabolism #SHVM 👇 https://t.co/n51LsQ5FPv
linkedin.com
Society for Heart and Vascular Metabolism (SHVM) | 93 followers on LinkedIn. 22nd Annual Scientific Sessions: Shedding Light on Emerging Metabolic Targets in Cardiovascular Diseases | We are pleased...
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Stay tuned for further updates as we near the 22nd Annual SHVM meeting: Shedding Light on Emerging Metabolic Targets in Cardiovascular Diseases 🫀 Abstract submission 17 March 2025 Early bird registration 18 April 2025 Registration and payment deadline 15 May 2025
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A big CONGRATS to @JordanSFChan , who successfully passed his #CandidacyExam this morning! Really proud seeing how much he has matured as a #scientist since joining the lab May 2021
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I'm looking to hire a fully funded PhD student this year. If you are interested in investigating mitochondrial bioenergetics in diverse tissues please reach out.
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Excited to share my work with @DanielJDrucker on the role for GIPR agonism alone and with GLP-1R agonism (@tirzepatide_ ) in the regulation of gut inflammation, and providing new insights on the localization of the GIP receptor in the gut. See paper here:
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Finally the latest baby of the Quebec PAH and vascular biology research group is out 😎. Congrats Dr Grobs @Grobs4
@3CPRCouncil @PVRI @ATS_PC @PullamsettiL @Savai_Lab @facmedUL
https://t.co/qlD5tVA5JC
science.org
ATP citrate lyase is a target for therapeutic interventions in pulmonary hypertension and coronary artery disease.
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Using multiple techniques the authors affirm that Gfral expression is overwhelmingly restricted to the brainstem in healthy mice @MolMetab @cusm_muhc @seeleyrj
https://t.co/OJA7Uhyc3N
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Check our last review in the special issue of Essays in Biochemistry on AMPK and AMPK-related kinase👉AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure https://t.co/3h7IzbUB8f
@ISHR_ES @escardio @GRRC_SFCardio
portlandpress.com
Abstract. Heart failure (HF) represents a multifaceted clinical syndrome characterized by the heart’s inability to pump blood efficiently to meet the body’s metabolic demands. Despite advances in...
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The SUMMIT trial Tirzepatide for #HeartFailure with Preserved Ejection Fraction in PPL with #Obesity A lower risk of a composite of death from cardiovascular causes or worsening heart failure
nejm.org
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
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On #WorldDiabetesDay2024 congratulations to Professor Erin Mulvihill @HeartInstitute @OttawaU @uOttawaBMI @CIHR_IRSC this years receipient of the early career investigator award from @DiabetesCanada Felicitations! #diabetes
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