Psychedelic Alpha
@Psyched_Alpha
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Empowering a diverse constellation of individuals and organisations with the knowledge, network and nuance to make an impact in psychedelic medicine and beyond.
Joined April 2020
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Introducing Pα+
We're launching a reader-supported model for our more analysis-focused content such as Psychedelic Bulletins, deep dives and interviews.
Read the announcement, and subscribe at a discounted launch rate, here:
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Elon Musk Comments on Psychedelics
“I think generally people should be open to psychedelics… A lot of people making laws are kind of from a different era. As the new generation gets into political power, I think we will see greater receptivity to the benefits of psychedelics.”
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Hamilton Morris says that trying 5-MeO-DMT has become a kind of status symbol among psychedelic enthusiasts.
However, the "molestation of toads" is not sustainable.
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The definitive source for psychedelic investors.
Breaking news, investor resources, plus exclusive interviews and financing opportunities.
Explore our resources and join our newsletter today:
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Yang wants to legalize pot, mushrooms, MDMA for military vets to treat PTSD
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BREAKING: UK Regulator Urges NHS to Offer Therapy Before Antidepressant Medication
"Millions of people with mild depression in England should be offered therapy, exercise, mindfulness or meditation before antidepressants."
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BREAKING: Alberta Will Regulate Psychedelics for Use in Therapy
🇨🇦 Canada's 4th largest province, which has a population of 4.5 million, will become the first to regulate psychedelics when rules come into effect in January 2023.
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BREAKING: UK PM Boris Johnson to consider calls to legalise magic mushroom drug psilocybin
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How magic mushroom ingredient psilocybin helps patients with depression or PTSD change how they feel, by rewiring the brain with more connections
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BREAKING: Bill to Decriminalize Psychedelics in California Passes State Assembly Committee on Public Safety
✅ Aye: 5
❎ No: 3
🗳️ Another success for Scott Wiener's SB 519.
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I'm Giving $100 Million to Psychedelics Research
Blake Mycoskie, founder of TOMs shoes, explains why he's committing a significant sum to support psychedelic research.
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MDMA therapy for PTSD expected to get US approval after latest trial
"US regulators could soon authorise MDMA-assisted psychotherapy for post-traumatic stress disorder after positive results in the largest clinical trial to date"
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Study Finds 65% Of Americans With Mental Health Conditions Want Access To Psychedelics
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Elon Musk again comments on psychedelics in a positive light.
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The FDA has accepted Lykos Therapeutics’ (formerly MAPS PBC) New Drug Application for MDMA-assisted therapy for PTSD.
The agency also granted Priority Review and set a target PDUFA date of August 11, 2024, meaning Lykos should expect a decision by that time.
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BREAKING: California's SB-519, which would decriminalise certain psychedelics, has been set for hearing on 3 August 2022.
The Bill will go before the Assembly Appropriations Committee next month.
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BREAKING: FDA Rejects Lykos Therapeutics’ MDMA-Assisted Therapy For PTSD
FDA requests additional Phase 3 study from Lykos. The company says it will request a meeting with the agency and urge it to reconsider its decision.
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'I took magic mushrooms at 64 and the fog I've lived under my whole life lifted'
"After successful clinical trials of psilocybin for treating depression, there are now calls for its wider use"
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BREAKING: State of Kentucky Sets Aside $42 Million for Psychedelic Research
The money, carved out from Opioid Settlement Funds, will be used for psychedelic research, specifically ibogaine for opioid addiction.
The funds will be allocated over seven years.
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DC Voters Decriminalise Psychedelics
Washington, DC Initiative 81 to Decriminalise Psychedelic Plants Has Been Called as a Yes.
Live vote count:
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🗺️ The Psychedelic Sector Landscape 🗺️
A visual overview of the psychedelic sector, organised by market segment or area of focus: from supply right through to delivery.
Interactive version:
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BREAKING: MindMed $MMED To Commence Trading on Nasdaq
MindMed will become the second psychedelics company to trade on the Nasdaq.
Ticker symbol $MNMD, expected to list April 27th.
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MDMA 'will be rolled out in US hospitals by 2024'
MAPS PBC expects to submit a New Drug Application (NDA) to FDA "within months".
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Johns Hopkins Medicine Receives First Federal Grant for Psychedelic Treatment Research in 50 years
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Stroke victims to be given psychedelic drug DMT in groundbreaking study
Vancouver-based Algernon Pharmaceuticals is set to administer microdoses of DMT to those recovering from strokes.
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"The Department of Veterans Affairs will fund research on the use of psychedelic drugs like MDMA and psilocybin along with therapy to treat post-traumatic stress disorder and depression, the agency announced Friday."
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BREAKING: MindMed Announces Initiation of Phase 1 Clinical Trial of Intravenous DMT
The investigator-initiated study is led by Dr. Matthias Liechti as part of MindMed's ongoing collaboration with the UHB Liechti Lab.
$MNMD $MMED
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Center for Psychedelic Medicine Established at NYU Langone Health
"New Program Builds on Notable Achievements and Offers First-Ever Dedicated Training Program for Early Career Investigators in the Field"
MindMed $MMED provided $5m in funding.
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INVERSE: Magic mushroom study suggests psilocybin may reverse alcohol-induced braind damage
"The psychedelic could also tamp down cravings for alcohol."
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BREAKING: COMPASS Pathways' Phase 2b Trial of Psilocybin for Treatment-Resistant Therapy Published in NEJM
Becomes the largest published psilocybin trial to date.
Quick coverage & analysis to follow.
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“A letter from the Health and Human Services Department discloses the anticipated FDA approval of MDMA and psilocybin treatments.”
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On Monday evening Roland Griffiths, a pioneer in psychedelic and consciousness research, passed away.
Beyond Griffiths' immense impact on the field of psychedelic research, his legacy includes a Professorship Fund in Psychedelic Research on Secular Spirituality and Well Being.
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Only 2 participants in MAPS' Phase 3 MDMA for PTSD trial reported serious adverse events.
Both were in the placebo group.
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Kristen Bell reveals 'psychedelic drugs' helped her cope up with anxiety
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BREAKING: MAPS PBC Files New Drug Application for MDMA-Assisted Therapy for PTSD
Filing marks the first NDA submission for any psychedelic-assisted therapy
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BREAKING: MindMed Announces the Approval of Mescaline Study
$MNMD $MMED
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WHO Gives 5-MeO-DMT Generic Name: Mebufotenin
According to its International Nonproprietary Names for Pharmaceutical Substances (INN) list, the World Health Organisation has given 5-MeO-DMT the nonproprietary name "mebufoteninum".
(Image from Proposed INN list)
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Confirmatory Phase 3 Trial of MDMA Therapy for PTSD is “Successful”, Says MAPS
Today, MAPS has announced that its second Phase 3 trial of MDMA-assisted therapy (MDMA-AT) for PTSD confirms prior positive results.
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🇦🇺 Australia Recognises MDMA and Psilocybin as Medicines
Makes the country in the world to officially recognise the two drugs as medicines.
Our analysis:
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BREAKING: Canadians Overwhelmingly Support Legal Access to Psilocybin-Assisted Therapy, Poll Reveals
Survey commissioned by
@cdnpsychedelic
shows >80% of Canadians approve the use of psilocybin therapy for those with end-of-life illnesses.
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I Went to Rehab for Alcoholism 18 Times. Only Psychedelics Helped
“Using [psilocybin] four to six times has managed to achieve what the other therapies didn’t do in years.”
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BREAKING: Morgan Stanley Publishes Optimistic Report on Psychedelics
"Early results indicate that psychedelic therapy has the potential to fundamentally reshape how we think about and treat not only mental illness but a host of other conditions as well."
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The Telegraph: Magic mushrooms set to become UK’s ultimate weapon against depression
"A wave of companies have been approved to test psychedelic therapies under new rules drawn up following departure from the EU"
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BREAKING: The Chopra Foundation and MindMed Enter Into Letter of Intent to Partner on the Future of Psychedelic Medicines & Mental Wellbeing
$MMED $MNMD
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MAPS Completes Second Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD
According to the clinical trial registry entry, 121 participants were recruited and the study was completed on November 2nd.
Slightly ahead of the estimated completion date.
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I am dying of cancer. Black-market psilocybin gave me a new lease on life.
"Mushrooms worked magic on my mental health after a terminal diagnosis. More Canadians should have access to them."
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BREAKING: Australia Approved Psilocybin and MDMA for Use in Treating Depression and PTSD
It will be possible for MDMA to be prescribed for PTSD, and Psilocybin for treatment-resistant depression.
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Breaking: Health Canada today published notice of intent to amend the Special Access Program (SAP) removing prohibition on access to restricted drugs.
"Certain restricted drugs are now demonstrating potential therapeutic uses, including in Phase II and Phase III clinical trials"
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California Senate Approves Psychedelic Decriminalization Bill
"California took a step closer to decriminalizing personal possession of various psychedelic drugs as the state Senate passed a landmark bill on Monday."
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BREAKING: DEA Withdraws Proposal to Schedule 5 Psychedelic Tryptamines
The challenge was led by co-counsel Matt Zorn and
@calyxlaw
for
@TactogenInc
and
@MindstateDesign
, with many others involved.
This is a remarkable and unprecedented outcome.
5 psychedelic tryptamines, kept off schedule I?
DEA scheduling proceedings—terminated:
“DEA is withdrawing the proposed rule…canceling the public hearing & terminating the pending hearing proceedings”
Unprecedented outcome—a result of extraordinary lawyering by Matt Zorn
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MAPS' Second Phase 3 Study of MDMA-assisted Therapy Reports Positive Results, Paving Way for New Drug Application
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New Resource: Psychedelics Drug Development Tracker
A visual overview of the psychedelics drug development landscape, including clinical trial progress status.
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BREAKING: First Psychedelic ETF Expected to Launch January 2021 (NEO: $PSYK)
The world’s first Psychedelic ETF looks set to launch in January 2021, providing exposure to publicly-listed, psychedelics-focused life sciences companies in North America.
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'A landmark study shows the main compound in magic mushrooms could rival a leading depression drug'
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California Bill to Decriminalize Psychedelics Held on Call at the State Assembly Committee on Health
Aye: 5
No: 3
#SB519
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BREAKING: San Francisco Decriminalizes Entheogenic Plants and Fungi (Psychedelics)
Yesterday, SF made the investigation and arrest of individuals involved with adult use of entheogenic plants among lowest law enforcement priority.
The vote was unanimous, according to Decrim SF.
We are so thrilled to announce that our resolution to decriminalize plants medicines and psilocybin mushrooms passed in San Francisco. May compassion and love prevail here and everywhere! Thank you
@DeanPreston
and
@HillaryRonen
for the bravery and intelligence! 🧿🦋✌🏽🌈🙌🏾
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"Medical psilocybin use should be decided by a patient and their doctor, not the government"
@TheraPsil
's Bruce Tobin
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Prince Harry Explains Why Psychedelics Are A 'Fundamental' Part Of His Life
The Duke of Sussex said the drugs are like the "cleaning of a windshield" for him and help "remove life’s filters."
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"I believe that if people would learn to use LSD's vision-inducing capability more wisely, under suitable conditions, in medical practice and in conjunction with meditation, then in the future this problem child could become a wonderchild."
Happy Birthday, Albert Hofmann.
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🏦 MindMed Uplisting to the Nasdaq
Ticker Symbol: $MNMD
Expected to commence trading: Tuesday April 27th
Details:
$MMED $MMEDF
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New York Times: The Psychedelic Revolution Is Coming. Psychiatry May Never Be the Same.
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Colorado Looks Set to Decriminalize Psychedelics, Provide Legal Psilocybin Therapy
Proposition 122 apears to have narrowly passed, with 51.03% of counted votes in support of the measure.
However, the count is not yet final.
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American Medical Association to Issue First New Code for Psychedelic Therapies
A joint press release from COMPASS Pathways and MAPS PBC details the new code.
Full details expected July 2023.
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Spokesperson for MindMed CEO Provides Comment on J.R. Rahn's Sale of Shares
"...he plans to use a portion of the proceeds to establish the Clara L. Rahn Foundation, named after his late mother who was a child psychologist."
$MMED $MNMD
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The Scottish government has called for the decriminalisation of all drugs for personal use.
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MDMA as psychiatric treatment moves closer to US approval
"Long-awaited clinical trial data show psychedelic drug is effective at treating post-traumatic stress disorder in a diversity of people."
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MindMed collaborators take to the stage to share a first look at their Phase 2 LSD for Anxiety data.
$MNMD
#PSYCHSymposium
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Breaking: TheraPsil has secured its 13th exemption from Health Canada to allow access to Psilocybin-assisted therapy for palliative Canadians.
Cc:
@TheraPsil
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The current North American Psychedelics Index, which underlies the $PSYK ETF, contains:
$CMPS, $FTRP, $MMED, $GTMS, $ENBI, $SEEL, $CYBN, $MCUR, $HAVN, $NUMI, $MYCO, $NOVA, $PSYC, $RVV, $TRIP, $JNJ, $ABBV, $GTMS
Breaking news and analysis:
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We're restarting our Interviews series where we speak to folks across the psychedelics space.
Who should we speak to first?
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The Oregonian has Called It: Measure 109 Passes, Legalizing Psilocybin Therapy in Oregon.
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Mike Tyson reveals magic mushrooms ‘saved my life’ and hopes psychedelics can now change the world
Former heavyweight champion calls psilocybin an ‘amazing medicine’
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"A research team from UNC-Chapel Hill, UC San Francisco, Yale, Duke, and Stanford developed a new compound that hits the same brain cell target as psychedelic drugs, triggering long-lasting anti-depressant action without psychedelic effects in mice."
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"I want everyone to appreciate the joy and wonder of every single moment of their lives. We should be astonished that we are here when we look around at the exquisite wonder and beauty of everything."
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Which Psychedelics Company are you watching most closely as we enter 2021, and why?
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BREAKING: Numinus Wellness To Acquire Neurology Centre of Toronto, Plans to Create Centre for Psychedelic Neurology
$NUMI
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Diplo says he ran a marathon while on LSD. Experts say he's tripping.
"There isn't notable research to back up any physical boosts Diplo might have gained from taking LSD"
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The Economist: "Ketamine, psilocybin and ecstasy are coming to the medicine cabinet"
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1st Berkeley program trains, certifies psychedelic guides
"This fall, 24 people in a first-of-its-kind training program at the year-old UC Berkeley Center for the Science of Psychedelics are learning to safely guide patients’ psychedelic experiences"
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BREAKING: North American Psychedelics Index Published:
Which Companies Will Be in $PSYK, the First Psychedelic ETF?
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California bill would decriminalize psychedelics, paving the way for medical treatment
"The bill touts the benefits of the drugs and would expunge the criminal records for those already convicted of possession or use of a substance"
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Finland grants license for psychedelic drug therapy study
"A Canadian drug firm [Clairvoyant] is recruiting 50 people in Finland who suffer from alcohol addiction."
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Significant news from $NUMI and MAPS
Numinus and MAPS Public Benefit Corporation announce collaboration agreement to seek approval of MDMA-assisted psychotherapy for PTSD single-arm, open-label trial
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Psychedelics are "fixing people's brains," claims San Francisco's Senator Scott Wiener as he explains Bill SB 519.
Wiener's Bill would see psychedelics decriminalized in the state.
Cc:
@Scott_Wiener
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The effort to decriminalize psychedelic drugs in California gained momentum Tuesday after a after a key state Senate committee voted in favor of allowing adults to freely use and possess magic mushrooms and LSD.
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"For the second time, Representative Alexandria Ocasio-Cortez is proposing legislation that would remove barriers to federal research on the therapeutic potential of psychedelics like MDMA and psilocybin."
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FDA Clears MindMed $MNMD IND for MM-120 in Treatment of Generalized Anxiety Disorder
"FDA clearance leads to first commercial IND for LSD, enabling initiation of Phase 2b dose-optimization trial of MM-120 in early 2022"
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MindMed Announces Inclusion in FTSE Russell Indexes
"as of Friday March 19th, 2021, MindMed has been added to the FTSE Global Micro-Cap Index and the FTSE Total-Cap index."
$MMED $MMEDF
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The Biden administration is preparing for legal psychedelics within two years
"The letter marks an about face from decades of federal drug policy"
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MindMed becomes the fourth organisation to receive such FDA Breakthrough Therapy Designation for a psychedelic drug candidate.
Previously, MAPS, Compass Pathways and Usona Institute received the designation, for MDMA and psilocybin (x2), respectively.
MindMed Receives FDA Breakthrough Therapy Designation and Announces Positive 12-Week Durability Data From Phase 2B Study of MM120 for Generalized Anxiety Disorder
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BREAKING: European Union Grants €6.5M for Multi-Site Psilocybin Study in Palliative Patients
The 100-patient study - which includes those with COPD, atypical Parkinsonism, ALS and MS - is expected to commence in January 2025.
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Today, we begin publishing our 2022 Year in Review.
The series kicks off with an Op-Ed from journalist
@shayla__love
, who is among the most astute observers of the nascent psychedelics industry.
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Temporary Memorial at the Capitol Calls on FDA to “Follow the Science” and Approve Lykos’ MDMA
A memorial in DC consists of 150,000 dog tags and bears the message “APPROVE MDMA-ASSISTED THERAPY FOR PTSD”.
Photo: ‘Grunt Style Foundation’ via LinkedIn.
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Numinus engages two companies for market-making services.
$NUMI
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Dan Crenshaw and Elon Musk Add Fuel to Lykos ‘Dumpster Fire’ Drama
An excerpt from our latest Bulletin, written by our Editor,
@Josh__Hardman
.
It’s been another testy week in the admittedly nebulous psychedelic ‘community’, as those in favour of FDA approval of Lykos
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Happy 35th Birthday to MAPS!
We owe a great deal to
@MAPS
' relentless research and advocacy efforts.
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BBC: Psychedelic frees up depressed brain, study shows
"Psilocybin, a drug found in magic mushrooms, appears to free up the brains of people with severe depression in a way that other antidepressants do not, a study has found."
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2 more palliative Canadians approved to receive psilocybin-assisted psychotherapy.
It appears the precedent has been set, with these decisions taking just 10 days on average to be made.
Cc:
@TheraPsil
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MindMed’s ‘Total Elimination’ of Psychotherapy in LSD Study Stokes Debate Around Its Role in Psychedelic Therapies
We look at MindMed's claim to have ‘eliminated’ psychotherapy from its Phase 2b study and explore the broader ‘Spravato-isation’ of PATs.
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