Sandipan Chowdhury
@schow1729
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Biophysicist. University of Iowa.
Iowa City, IA
Joined April 2020
It’s sometimes funny, sometimes odd that some people find it necessary to mock others to prove their point. There’s value in “collective wisdom” and time being the “controversy settler”. GABA receptors are supposed to calm it down not elicit nastiness
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Now this could be a game changer (APPEARS TO BE sooooo much easier than affinity grids!)
Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv:
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Our lab at the Univ of Maryland has an NIH-funded #postdoc vacancy to investigate the structural basis of #SARSCoV2 hijacking of host trafficking #proteins. We use #cryoem, #Crystallography, & #OctetBLI. And #Rockville is an aewsome place. @UMD_IBBR @UMBaltimore @ChemBiochemUMD
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The best opening line in any physics textbook: States of Matter by David L. Goodstein ✍️
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We are thrilled to announce that the recipient of the 2024 Kenneth S. Cole Award is Dr. Benoît Roux from the University of Chicago. Join us in congratulating Dr. Roux! 🎉 #KennethSColeAward
https://t.co/DlUJxnkHNg
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Challenging my TRPVs and TRPAs.. Spice level 5! It burns, burns, burns… the pot of fire!!!
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The ultimate result of championing only hypothesis-driven science is to fill the world with scientists who care more about their hypotheses than exploring for an unexpected discovery.
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Our new pre-print: polyamorous BK channel now engaged to the Gamma subunit! How the TM and LRRD of Gamma influence its union with BK… Also the transporter model of VSD activation: a rotameric flip is all it takes to riot! A flipping journey!! https://t.co/4d2t0xBM9v
biorxiv.org
Multi-modal regulation of Slo1 channels by membrane voltage, intracellular calcium, and auxiliary subunits enables its pleiotropic physiological functions. Our understanding of how voltage impacts...
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Know an undergrad student, fascinated by the brain, who hasn't had an opportunity at their institution to pursue neuroscience research? Pls share about our iDREAM 2yr postbacc program in neuro! Jan.11th virtual info session.
Applications are open for our 2-year #neuroscience post-bacc program for recent graduates from colleges that don't offer bioscience PhDs https://t.co/lEqubfwlAS Meet faculty & current trainees at our virtual information session Jan 11, 2-3:30 CST. DM or email for Zoom link.
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I will print this in big letters! Jan Lowe’s thoughts on Kiyoshi scientific life…
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A-M-A-Z-I-N-G: a facultative channel, a facultative transporter…
Mitochondria possess a large, non-selective ionic current that is enhanced during cardiac injury. https://t.co/awyf8LRBdw
#bioRxiv
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It’ll be great to have a new postdoc in my group to lead a new project (biochem/biophys/ephys). If there’s anyone out there who wants to chat, message me. I might be a little weird, but the proteins we’re interested in are weirder!
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https://t.co/manUvPfJgb My first paper as a postdoc in the lab David Drew is out Check-out the.first structure of a unique transporter which is regulated by a voltage sensing domain. Great team work!!
nature.com
Nature - Upon hyperpolarization, the S4 voltage-sensing segment of sea urchin SLC9C1 moves down, removing inhibition caused by an intracellular helix and enabling Na+/H+ exchange, leading to...
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It’s bitter-sweet to see this paper out, along with its twin, but a validation that we’re picking important and challenging questions and pursuing them aggressively and in many ways, not too far behind!
I was often asked what I was working on in @CPaulino_ group. Well, here it is! 🥁🥳 What a fascinating combination of ion channel and secondary active transporter domains in one protein! Great teamwork with @MartinPeter91
@rheinbergerj
https://t.co/zsEpMrUMEj
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As everyone celebrates and congratulates new Nobel Prize winners, I turn attention to another group of scholars, celebrating their work eg. “Why many scientists like to lick rocks…” 🧐 https://t.co/ji4lF3YHoX
improbable.com
Ig® Nobel Prize Winners For achievements that first make people LAUGH then make them THINK Winners by year: 2025 : 2024 : 2023 : 2022 : 2021 2020 : 2019 : 2018 : 2017 : 2016 2015 : 2014 : 2013 : 20…
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Introducing OPUS-DSD, an algorithm that efficiently reconstructs the dynamic structural variation landscape embedded in macromolecular cryo-EM data. OA paper: https://t.co/st2YCyvsov
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Such a cool application of HS-AFM in indirectly probing T-sensitivity of TRPs. But the fluctuations NEED to be enthalpically distinct to contribute to DeltaCp and if not then it would mean something else. https://t.co/FvIxD5jLjo
pnas.org
Transient receptor potential vanilloid member 1 (TRPV1) is a heat and capsaicin receptor that allows cations to permeate and cause pain. As the mol...
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