Pascal Devant
@pascal_devant
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Postdoc @Marsonlab @GladstoneInst @UCSF | PhD in Virology with @jkagan1 @harvardmed | Interest in Mechanistic Immunology, Cell Biology, Synthetic Biology
Joined July 2021
Ever wondered how inflammatory caspases recognize IL-1 cytokines for cleavage?.Read more in our new paper, a collaboration between @jkagan1 and @WuLabHarvard labs out today @Nature . See🧵👇.1/.@harvardmed @BostonChildrens @VirologyHarvard @HarvardMicro.
nature.com
Nature - The human lipopolysaccharide receptor caspase-4 captures its cytokine substrate pro-IL-18 via a mechanism that is distinct from known caspase–substrate interactions, leading to...
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RT @ShiyuXia: In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecu….
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RT @taabaman: Chris's @TheBourneImmuno paper is online now. Huge thanks to @BookerMan_PSU for coordinating this special Juneteenth issue @A….
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RT @GladstoneInst: Congrats to Gladstone Postdoc @pascal_devant who was named a 2025 Jane Coffin Childs Fellow!. #JCCFellow. .
jccfund.org
The Jane Coffin Childs Memorial Fund for Medical Research (Jane Coffin Childs Fund/JCC Fund) is a leader in biomedical research funding, having committed funding to early-career research leaders for...
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RT @BorsicElvira: Ever wondered where NLRP3 needs to be in the cell to activate the inflammasome? Turns out, it does not really matter. Che….
nature.com
Nature Communications - NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants...
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New insights into the noncanonical inflammasome point to caspase-4 as a druggable target. Interesting perspective by Judy Lieberman, @WuLabHarvard, and colleagues. @NatRevImmunol .
nature.com
Nature Reviews Immunology - This Progress article describes recent studies showing that the human lipopolysaccharide sensor caspase-4 activates pro-IL-18 and causes vascular leakage by inducing...
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RT @Anh_Immunology: Finally, our study on caspase-11 and its CARD-recognized molecular pattern is out in Science Advances! A small step, bu….
science.org
A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.
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RT @LabWaggoner: Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants. https://t.c….
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RT @Synth_Immune: Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade. Out now @Nature from….
nature.com
Nature - A study finds that a protease called granzyme K can activate the entire complement cascade, explaining how it can drive destructive inflammation in inflammatory diseases such as rheumatoid...
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RT @j_eyquem: 🚨New paper alert! 🚨 Our latest work in @ImmunityCP shows that Ark313, an evolved AAV variant enables in vivo genetic enginee….
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RT @LabWaggoner: Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth.@NatImmuno….
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RT @KingOfPathogens: Anyone left on Science Twitter who has spike specific CD8+ T cells? Wonder how you made them? Wonder no more. #27 @Cyt….
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RT @jkagan1: Introducing Dr. Anh Cao! .So proud of this outstanding scientist, who defended his thesis today. @harvardmed @Anh_Immunolo….
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RT @maya_arce_: Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led….
nature.com
Nature - Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.
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RT @jkagan1: De novo creation of an innate immune LPS receptor. Anh Cao identified the principles of LPS detection by caspase-11, revealing….
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RT @DanielleMClancy: Excited to share our newly published preview in @ImmunityCP covering recent insights into IL-18 activation! There is s….
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Big 'Thank you' to @SavvidesLab @DanielleMClancy for writing this thoughtful spotlight @ImmunityCP on our recent work on the 'The pros and con(formation)s of IL-18 activation'.
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RT @jkagan1: For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. To….
nature.com
Nature - Myddosomes, in which MyD88 forms barrel-like scaffold structures for effector protein recruitment and activation, contain proteins that act at all stages and regulate all effector...
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