Finger-prick blood testing🩸shows promise to help traumatic brain injury / Alzheimer's diagnosis, as this remarkable technology continues to improve. Wonderful working with @NicholasAshton Magda Mike Hanna Henrik @PareshMalhotra @Neurosharp & more on it:

Great opportunity to join @Neurosharp team at @ImperialBrains as a research assistant, working on late-consequences of military neurotrauma. Do reach out if you'd like to know more about the role. (Closing date 1st April).

RT @foltynie: Many thanks to esteemed authors especially @ajlees and of course @TheLancet for helping us write the third in this series of….

RT @wagnersbrum: We evaluated the biological variation of 🩸 p-tau (217, 231, 181), Aβ, NfL and GFAP weekly over 10 weeks in healthy individ….

RT @PFA: If you are a retired player between the ages of 30 and 55 and would like to check your eligibility for a brain health assessment,….

RT @PFA: This month, PFA CEO @Maheta_Molango and Chair @BecklesOmar visited the Advanced BRAIN Health Clinic at @TheISEH in central London.….

Semaglutide in nondiabetic adults with obesity - remarkable cardiovascular effects (MI, stroke) with also a significant drop in mortality. Trial in NEJM

Remarkable:

Informative discussion of new Alzheimer’s treatments, with @PareshMalhotra @ProfRobHoward on @BBCMoreOrLess. A great listen.

RT @braincomms: Parker et al. report that head injuries during elite rugby games may result in localised cortical swelling that correlates….

Pleased to see this comment with @Neurosharp published looking at the great work of the TRACK TBI team on dynamic patient trajectories years post-injury. More to be done to understand things at a mechanistic level but key implications for patient monitoring & treatment trials.

RT @WillStewNeuro: "Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Veteran Men - A Twin Study". Twin study d….

The team has previously published on the performance of different markers MTBR-tau275 and 282, which do pretty well with CBD, PSP, FTLD-MAPT (and AD to a lesser extent) . Seems like an important new direction.

Important paper on a new fluid biomarker for tau tangle pathology (MTBR-tau243) in Alzheimer's disease. The authors show it works well in CSF. Next step is blood testing. Awesome work. Will be interesting to know if this works in other tauopathies like CTE 👏👏👏.

A superb innovation from the Imperial cardiology team.

RT @AdelHelmy79: Many congratulations to all partners on securing funding for TBI Reporter, an ambitious platform for TBI research @Menon_C….

RT @LabPascoal: Why many Aβ-positive cognitively unimpaired individuals do not develop downstream tau pathology? Our new study led by @Bell….

RT @cathmummery: Very proud and excited about this paper - we present results of the first #genesilencing treatment in #alzheimers disease….

Excited to share our plans for ADVANCE-TBI, investigating long-term neurological outcomes of traumatic brain injury in UK armed forces personnel . @AdvanceStudy @dms_dmrc @DrA_N_Bennett @Neurosharp @GusZimmerman @ntfear with thanks to the ADVANCE charity

Impressive evaluation of GPT-4 on medical exam questions (eg. USMLEs) from Microsoft/OpenAI @erichorvitz @HarshaNori Interesting work (section 6.2) to test whether the model saw the exam in its training. They think probably not, but hard to be sure.