Promise & risk of AI in biology: We share in @ScienceMagazine our efforts to identify & mitigate DNA screening vulnerabilities. Grateful to a fabulous team of collaborators, across organizations.

Trusting AI in medical applications: Nat'l Academy of Medicine panel on "Building Trust: AI Governance & Ethics in Medicine and Health" https://t.co/HMEr6AsV0r @theNAMedicine @johnhalamka @DrCaliff_FDA @VarditRavitsky @kbjohnsonmd

Highly recommended presentations & discussions on frontier research projects. @StanfordHAI @Stanford @landay

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Artificial intelligence is spreading faster than any technology in history. Yet today’s map shows a clear divide. @Microsoft's AI Economy Institute’s new AI Diffusion Report assesses where the world stands today, while laying out the steps to expand access, build skills, and make

Agents and economics: Platform for studying worlds that we can expect. Focus: Exploration of two-sided agentic marketplace.

Introducing the Synthetic Biology Risk Consortium (SBRC), building on collaborations sparked during Paraphrase effort. Work includes def'n of "sequences of concern" to address biosecurity risks of synthetic nucleic acids created via in silico design. https://t.co/NoSTzpKPaJ

Promising direction, led by intern @martinagvilas, on the path to learning how to better guide test-time reasoning. Enjoyed working with Martina and a great team of co-authors @MSFTResearch

Tandem Training for Language Models: https://t.co/fiLq7VvN5v “With an eye on long-term futures, we pursue methods that encourage models to produce solutions that remain intelligible to weaker collaborators.” Intelligibility as robust handoff. @cervisiarius @ashton1anderson

Upcoming panel at the @GalienFdn Patient Summit: "From Promise to Practice: Navigating AI's Potential in Enhancing Patient-Centered Care" More here: https://t.co/uZnDoYJ3U3

Paraphrasing a protein is like paraphrasing a sentence—the words change, but the meaning holds. Microsoft scientists applied this concept to toxic proteins, revealing a blind spot in DNA screening and leading a cross-sector team to develop a fix. https://t.co/kKAZwNOsN4

A pleasure to collaborate with Adam Clore at @idtdna on the Paraphrase project. @MSFTResearch

Laude Institute call for Moonshots. First phase of moon: Abstracts due October 25. https://t.co/wu2fKgxgft

How do we decide what not to share? I explore “information hazards” in this blog--on when openness in science risks misuse. The Paraphrase Project led to a first-of-its-kind publishing model, accepted as a precedent by Science: "When AI Meets Biology"

Some background on the Paraphrase Project, published in Science last week, including some of the behind-the-scenes story, my blog on the disclosure dilemma, and a conversation with Bruce Wittmann, Tessa Alexanian, and James Diggans. @msftresearch

Full paper available at https://t.co/AG2ULosTYK.

The work continues on with advancing AI + biology responsibly, Much more to do. We need to stay on it. @MSFTResearch @TwistBioscience @idtdna @SecureDNA @Battelle @LLNL_SciTech @RTX_News @aclid @NIST @NTI_WMD @StanfordHAI

Our solution: a novel perpetual access framework—a non-profit org (@IBBIS_bio) serves as gatekeeper, with data store & process supported by an endowment, ensuring responsible access for scientists in perpetuity. Grateful this approach was accepted by @ScienceMagazine editors.

In a critical phase of the project, we weighed the “information hazard” of sharing technical details. We faced the tension of supporting scientific progress in AI & biosecurity while guarding against misuse. We drew input from experts in gov’t, academia, industry, nonprofits.

Guided by failures to detect, brought to light by intensive AI red-teaming, we developed “patches.” The vulnerabilities and mitigations were shared confidentially with DNA synthesis companies worldwide via the Int’l Gene Synthesis Consortium (IGSC).

We explored how AI protein-design tools can “paraphrase” toxic & viral proteins—reformulating amino acid sequences while aiming to preserve structure and potential function. We found that paraphrased proteins could fly through DNA synthesis screening tools.