Our new @Cell_Metabolism study proposes a mechanistic connection between molecular remodelling in development & aging. We uncovered a common transcription factor pattern linked to chromatin remodelling in organismal maturation & aging. Link Thread 🧵👇1/10

RT @SamStehbens: Say whaaat!?? 👇👇👇ever wanted to visit Australia & see great science?? .‘We are excited to announce that the next Hunter Me….

RT @Cell_Metabolism: A pattern emerges in chromatin aging: AP-1 steals the show

RT @agingdoc1: A pattern emerges in chromatin aging: AP-1 steals the show.

🙏 to Manuel Serrano for writing a preview 👉 for our study NOW IN PRINT @Cell_Metabolism. We introduce the "Stimulus-Induced Programming Hijacks Ontogeny" (SIPHON) model for chromatin & transcriptome remodeling in organismal maturation & aging. We provide

Thanks! We provide compelling data that “cell identity loss” in aging represents the hijacking of a developmental mechanism via epigenetic de-repression of AP-1 rich regulatory elements. The resulting predictable transcription factor network changes may drive many aging.

RT @agingdoc1: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening. ht….

RT @ydeigin: 🤔 Interesting recent result connecting development and aging:. “AP-1 … progressively activated adult genes, whilst the activit….

RT @LongevityTech: Master controller of aging and development uncovered.New insights into transcription factors and chromatin remodeling re….

RT @jpsenescence: Very cool multi-omic analysis of development and aging across >45 mouse and human cell types. They find a transcription….

The study was big collaborative effort LED BY talented co-first authors @rjPatrick19 & @MarinaNaval, with CRUCIAL CONTRIBUTIONS from @nikkideshpande, Yifei Huang @Jason836452, Jingyu Zhang @IAMorlandozhang, Xiaoli Chen, Ying Yang @haokandeyy, @Mohammad_E1990, Kanupriya Tiwari,.

Excited that Channel 7 & 9 covered our @Cell_Metabolism study along with 62 news outlets. It suggests AP-1-linked chromatin opening drives organismal maturation across cell types by disrupting the activity of 'early-life' gene regulatory elements—a mechanism hijacked in aging via.

RT @IMBatUQ: Researchers have unlocked crucial molecular secrets of ageing in cells, potentially paving the way to improve quality of life….

RT @LabWaggoner: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening @….

RT @DrQuinn4realz: Huge congrats to @nefzgerc and his team at @IMBatUQ on this epic paper that identifies fundamental molecular patterns t….

RT @MarinaNaval: Excited to share our latest work in @Cell_Metabolism and lead by @nefzgerc @rjPatrick19 and myself @MarinaNaval uncoverin….

RT @ARMI_Labs: ARMI researchers have contributed to a new paper, published in @Cell_Metabolism, demonstrating a mechanistic connection betw….

RT @Cell_Metabolism: New! Online now: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-link….

@dkv_scientific @rjPatrick19 @MarinaNaval 10/10 The work spanned multiple Australian institutions 🇦🇺 and international collaboration including @IMBatUQ, @UQ_News, @MonashUni, @ARMI_Labs, @UniMelb, @CSIRO, @SVIResearch @RMIT @AIBNatUQ @TheDohertyInst @FrazerInstUQ @NIH @UnivLyon1. 🙏 to @Nhmrc @IMBatUQ @AdvanceQld for.

@dkv_scientific 9/10 The study was led by talented co-first authors @rjPatrick19 & @MarinaNaval, with important help from the lab by Yifei Huang, Jingyu Zhang, Xiaoli Chen, Ying Yang, Mohammadhosein Esmaeili & former members Nikita Despande, Kanupriya Tiwari. 🙏 for cell isolation support by.