Ben Munro
@munromit
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Postdoc in the Larsson lab @molmet_ki @karolinskainst Interested in mtDNA regulation in health and disease 🧬
Stockholm, Sweden
Joined October 2019
Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome https://t.co/mSZMVJU2at
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We're looking for a postdoc! 🧑🔬 If you're interested in mitochondrial genetics, have a look below! 🧬🔬🥼 Feel free to ask any questions. https://t.co/ufQ7bkM2De
ki.varbi.com
Postdoctoral studies in mitochondrial genetics (scholarship) Do you want to contribute to improving human health? Join a leading research team dedicated to understanding how mutations of mitochondrial
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Big thanks to everyone involved, especially the animal technicians, and Declan, who spent a summer internship meticulously analyzing zebrafish touch-evoked escape response data. A very tedious (but vital!) part of the work! 🐟
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This proof-of-concept study highlights that deoxynucleoside supplementation can mitigate RRM2B dysfunction in vivo. More challenges remain in bringing this to patients; determining effective delivery methods, combinations, and dosing of deoxynucleosides is vital!
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We subsequently establish that purine deoxynucleoside supplementation in Rrm2b KO larvae prevents mtDNA depletion, attenuates the movement defect and reduces lactate levels. This supports existing in vitro data that deoxynucleoside supplemention could treat RRM2B related MDDS.
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In zebrafish, knocking out Rrm2b causes impaired movement, mtDNA depletion & elevated lactate. Surprisingly, treating larvae with both purine & pyrimidine deoxynucleosides worsened mtDNA depletion, even in WT controls. Likely due to nucleotide pool asymmetries in larvae.
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RRM2B mutations disrupt purine & pyrimidine deoxynucleotide pools essential for mtDNA replication and maintenance. This leads to mtDNA depletion & a severe encephalomyopathic form of MDDS in patients.
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🧬 New paper! We nudge the science forward surrounding deoxynucleoside supplementation & mitochondrial DNA depletion syndromes (MDDS). We show, for the first time in vivo, that deoxynucleoside supplementation can mitigate effects of RRM2B mutations.🔗
academic.oup.com
Abstract. Mitochondrial DNA (mtDNA) depletion syndromes (MDDS) are rare, clinically heterogeneous mitochondrial disorders resulting from nuclear variants i
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Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI For the PhD position: https://t.co/9ZsHC4RbqJ For the PostDoc position: https://t.co/MOBdoUy10K
ki.varbi.com
Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct
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🚨PostDoc Alert! We are looking for an enthusiastic and driven #PostDoc to study the role of mitochondrial dysfunction in neurodegenerative diseases. Join my research group @MolMet_KI within @karolinskainst! #Mitochondria #Neurodegeneration #MitoJobs
https://t.co/ksqC0jgsiy
ki.varbi.com
Do you want to contribute to improving human health? Division The Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunction
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We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo
https://t.co/xLNyW00oil
nature.com
Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...
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We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs
https://t.co/tOv2e05PHF
ki.varbi.com
Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct
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New study from us: https://t.co/GioeqFmsKo High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
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🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article:
academic.oup.com
Abstract. In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex i
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🚨Advance article alert - mutant PTPMT1 impairs cardiolipin metabolism causing human disease. Fantastic collaborative effort across several continents! Biallelic PTPMT1 variants disrupt cardiolipin metabolism and lead to a neurodevelopmental syndrome
academic.oup.com
PTPMT1 is crucial for biosynthesis of the signature mitochondrial phospholipid, cardiolipin. Falabella et al. show that loss of PTPMT1 function is associat
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New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: https://t.co/qDhEd7WCtN Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
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After 7 years, yesterday was my last day in @HorvathLab . Thanks to all those past and present who made my time a special one! I'll miss everyone!
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We are hiring! More details here👇🏻👇🏻
Bioinformatician - Single Cell Genomics in Neurodegenerative & Mitochondrial Disease: https://t.co/NmqnT98fNo Lead an exciting project to shed light on the fundamental biology of neurodegenerative diseases and #mito dysfunction. @Jellevda @HorvathLab @MRCMitoCluster @MRC_MBU
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BREAKING NEWS The 2023 #NobelPrize in Chemistry has been awarded to Walter White for promoting an understanding of synthetic organic chemistry to the general public. This unprecedented selection is bound to spark controversy, but Walter is/was an undeniably inspiring figure...
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Exciting #job alert! Are you interested in #mitochondria, #neurons and #muscle? We are recruiting a Research Assistant to support ongoing research and help organize the lab. More details 👇 https://t.co/I6S3kNfsmR Please RT
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