Roberta Filograna
@RobertaFilogra2
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Exciting news from Pretzel Therapeutics! We’ve launched a Phase 1 trial for our POLG activator—PX578—targeting rare mito. syndromes with potential for Parkinson’s & Alzheimer’s diseases Congratulations to the entire team—proud to be part of this journey! https://t.co/awSYPopysq
pretzeltx.com
First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes
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Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI For the PhD position: https://t.co/9ZsHC4RbqJ For the PostDoc position: https://t.co/MOBdoUy10K
ki.varbi.com
Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct
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🚨PostDoc Alert! We are looking for an enthusiastic and driven #PostDoc to study the role of mitochondrial dysfunction in neurodegenerative diseases. Join my research group @MolMet_KI within @karolinskainst! #Mitochondria #Neurodegeneration #MitoJobs
https://t.co/ksqC0jgsiy
ki.varbi.com
Do you want to contribute to improving human health? Division The Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunction
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We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo
https://t.co/xLNyW00oil
nature.com
Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...
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New study from us: https://t.co/GioeqFmsKo High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
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🚨Save the date!🚨 Co-organized by our CRC1218 PI, Elisa Motori EMBO Workshop “Mitochondria in the Nervous System” 🧠⚡ in beautiful Engelberg, Switzerland 🗓 Sept 29 - Oct 2, 2025 Spaces are limited, keep an eye out for registration! #Mitochondria #BrainScience #EMBOWorkshop
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🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article:
academic.oup.com
Abstract. In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex i
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Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with @taylorlabncl and @lukas_k
https://t.co/Vak11bWg0F
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We are excited to share our lab's first preprint, highlighting the role of the CHCHD2-CHCHD10 complex in preserving tissue homeostasis. A huge thank you to all our collaborators! https://t.co/21K1yuwd5H
biorxiv.org
The highly conserved CHCHD2 and CHCHD10 are small mitochondrial proteins residing in the intermembrane space. Recently, mutations in the CHCHD2 and CHCHD10 genes have been linked to severe disorders,...
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New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: https://t.co/qDhEd7WCtN Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
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Our study is finally out! https://t.co/RYUgW9J8ow We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient. Thanks to @mitopinionated , @LabMotori, @perlmannlab and Per Svenningsson for the great collaboration!
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I have the honor and pleasure of co-organizing the EMBO workshop on Molecular Biology of Mitochondrial Gene Maintenance & Expression, with an amazing lineup of speakers! Join us in Poland from May 19-23! Early-carreer researchers especially encouraged! https://t.co/xmH3m5QXGC
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Just a few days left to apply for a #Postdoc position! Join us in the vibrant work environment at @MolMet_KI in Stockholm!
PostDoc opportunity! We are looking for an enthusiastic #PostDoc to study how mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative disease. Join my research group within @MolMet_KI @karolinskainst
https://t.co/RZFcbWHhwm
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PostDoc opportunity! We are looking for an enthusiastic #PostDoc to study how mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative disease. Join my research group within @MolMet_KI @karolinskainst
https://t.co/RZFcbWHhwm
ki.varbi.com
Do you want to contribute to improving human health? The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial d
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Are you interested in understanding the molecular basis of mitochondrial DNA disease? We are looking for enthusiastic PostDocs to join the group of Nils-Göran Larsson (@mitopinionated) within @MolMet_KI at Karolinska Institutet, Stockholm. https://t.co/5O6PaCKRTF
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Please see our latest mitochondrial transcription review, together with Ben Tan @mustloveDNA: https://t.co/JEnc9atpA4
nature.com
Nature Reviews Molecular Cell Biology - A unique feature of mitochondrial DNA function is the coupling of initiation of transcription with that of replication. Tan et al. discuss the choice between...
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Two neighboring cells can be so different! Releasing scDVP - single-cell #DeepVisualProteomics for combined imaging and mass spectrometry-based proteomics in the intact tissue context. One cell at a time. https://t.co/9X1pZnPZjF
@naturemethods Here’s a summary! (1/n)
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New preprint from us! Paradoxically, daily treatment of obese mice with inhibitors of mitochondrial transcription (IMT) prevents diabetes and hepatosteatosis. The fatty acid oxidation is increased in liver despite a drastic reduction of mtDNA expression: https://t.co/EXsnGTnQSm
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The study "PARKIN is not required to sustain OXPHOS function in adult mammalian tissues" by @RobertaFilogra2 et al now online: https://t.co/5aMyIY0SKN PARKIN loss does not impair OXPHOS function in different tissues of ageing mice or in skeletal muscle of an adult human patient.
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Faculty position at Karolinska, in the wonderful Solna campus across the street from us at SciLifeLab.
Come and start your own lab in biomedical research at our department @karolinskainst! With a generous startup package, great critical mass and colleagues as... https://t.co/r9hvOONMiM
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