Michael S. Balzer
@ms_balzer
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MD FASN | Nephrologist | #ClinicianScientist @ChariteBerlin | Editorial fellow @JASN_News | #SingleCell | Determined to understand adaptation to kidney disease
Berlin, Germany
Joined January 2021
Alright, #MedTwitter #NephTwitter 🫘 The time has come to move on. Would love to stay in touch! Find me at 🦋
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RT @NEJM: Original Article: Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease (EMPA-KIDNEY) .
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Instrumental work by Hiroaki Kikuchi from @MarkKnepper6 lab on what instigates renal compensatory growth #kidneyweek2024
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Fantastic talk by @MiguelCheSoares on labile heme and Host-Microbe interactions in the context of AKI #KidneyWk2024
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Want to know how to extend your kidneys’ lifespan? Starting off “Opposing Demands in Kidney Injury: How to Adapt” with Martin Späth leveraging caloric restriction for kidney injury. #kidneyweek2024
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Is fibrosis🐓or🥚? Fantastic talk in the spatial session by @Ina_M_Schiessl on intravital tracking of kidney tubules. #kidneyweek2024 #kidneyweek
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RT @rajmehrotra1122: Great gathering of the best editorial team at #KidneyWk @JASN_News @ASNKidney
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Congrats @AminAbedini1990 @KSusztak and team! 🔥🔥🔥.
🔥😀Super-super excited to report the publication of "Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression" in @NatureGenet by @AminAbedini1990 and Jon Levinsohn #kidney
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RT @UKEHamburg: Prof. Dr. Tobias Huber aus dem #UKEHamburg ist vom @ERC_Research mit ERC Advanced Grant ausgezeichnet worden. Sein Forschun….
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RT @JASN_News: "The nephrology community has lost one of its truly remarkable figures. " Drs @JochenReiser and Martin Zeier remember the l….
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RT @LVRiella: With tremendous joy, I share that our patient who received a gene-edited pig kidney transplant was discharged home today afte….
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RT @Xiaojie_Qiu: Thrilled to share that Dynamo v1.4 ( for single cell and metabolic labeling enabled RNA velocity v….
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RT @KuppeChristoph: 🎉 Happy to share our first 📜 2024!🔬 Our review article in @GenomeMedicine on the innovative use of spatial multi-omics.….
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Huge thank you 🙏to all involved: 👏@cetin_sz, Kathrien Abdank, @AminAbedini1990 @KSusztak Kai-Uwe Eckardt.@BIH_Innovation @EKFStiftung. Check out the 🔥paper in @NDTsocial: Eo/🧵
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CONCLUSION: our straightforward analytical framework.✅effectively positioned pre-clinical models along human biology (AKI-to-CKD);.✅showcased robust biological pathway concordance across species;.✅identified problematic datasets and samples. 6/🧵.
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Cross-species & cross-dataset enriched pathways by phenotypes:.1.😊Health: ion transport, solute carriers….2.🥵early AKI: cell matrix, adhesion, EMT….3.🥵late AKI: immune system processes….4.🤕Recovery: combination of Health & Recovery.5.👿CKD: hypoxia, TNFɑ/NFκB, IL18…. 5/🧵
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Outlier #CKD datasets had tubular epithelial cell fractions comparable to healthy datasets, underscoring the importance of cell fractions as prerequisites in the interpretation of #singlecell datasets. 4/🧵
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