Mark Knepper
@MarkKnepper6
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Systems biology ... Kidney biology ... Biomedical engineering ... Google Search: "Knepper Systems Biology"
Bethesda
Joined June 2020
Why RNA-seq alone falls short in explaining physiological and pathophysiological regulation:
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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Liquid-liquid phase separation in cell signaling . Wnt, Hippo, cAMP-PKA, cGAS-STING. Hot area of research .
cell.com
Su et al. review the broad impact of liquid-liquid phase separation (LLPS) on various cellular processes and signaling pathways, emphasizing the spatiotemporal regulation of cell signaling by LLPS...
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Black men are pushed to pursue sports. Why not medicine? via @MotherJones.
motherjones.com
Dedicated athletes share qualities that can bring success elsewhere—with a little encouragement.
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Sad to learn that honey, a mixture of glucose/fructose is not good for you. Always thought it was a health food.
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Kizzmekia Corbett and Barney Graham Recognized for Leading NIH Intramural Vaccine Research, Development of Moderna Vaccine
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Edmond Fischer, who won Nobel Prize for discovery of protein phosphorylation, dies at 101
washingtonpost.com
His studies advanced research on cancer, diabetes and drugs to prevent the rejection of transplanted organs.
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. including a transcriptomic profile of macula densa cells . .
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Another important step in understanding how vasopressin regulates aquaporin-2 trafficking from Brown lab.
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G-Protein Coupled Receptors in Mouse Renal Intercalated Cells and Principal Cells - Single-Cell RNA-Seq Analysis
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Microdissected renal tubules (with JNa, IF, RT-PCR and even IB). ENaC is not the only sodium channel of significance in kidney:
pubmed.ncbi.nlm.nih.gov
Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC)...
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"The canonical V2R signaling pathway . cannot fully explain AQP2 plasma membrane targeting and cAMP–PKA-independent pathways exist." -Olesen and Fenton.
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New role for WNK1 not dependent on protein kinase activity. Relevant to KS-WNK1?
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Microdissected renal tubules from Larry Palmer and friends (plus AW math modeling).
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