VanniniLab_HT
@VanniniLab
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Our Team at @humantechnopole Milan works on #RNAPolymeraseIII #SMC complexes and associated factors in genome function/organisation
Milan, Lombardy
Joined August 2016
🎓 Just graduated and passionate about Computational #Biology, Structural Biology, #Genomics or #Neurogenomics? Apply by 8 Sept for 1 of 9 fully funded PhD scholarships via the @semm_it Program at HT in Milan! 👉 https://t.co/sNT1CWwXJ8
#PhDlife
humantechnopole.it
Are you passionate about science and ready to take the next step in your research journey? Human Technopole is offering up to 9 fully funded PhD scholarships through the highly regarded SEMM PhD...
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🧬 How does our DNA get packed up for cell division? Our @VanniniLab has uncovered how a protein called M18BP1 switches on condensin II – the machine that compacts our #genome. 🧠 A key piece of the mitosis puzzle, now in @MolecularCell 👉
humantechnopole.it
As a result of an international collaboration, Human Technopole researchers identify M18BP1 as an activator of condensin II through a phosphorylation-regulated competition with MCPH1. This previously...
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Condensin II activation by M18BP1: Molecular Cell
cell.com
Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase...
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🚨 We're Hiring! We're looking for a passionate and skilled EM Specialist to join our team! 📅 Application Deadline: July 9th, 2025 🔗 Learn more and apply here: https://t.co/fLHKZUChI3
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This is a game changer: AAV gene therapy for Cockayne syndrome 👇 https://t.co/HB8AoBppa2
biorxiv.org
Cockayne Syndrome (CS) is an autosomal recessive, progressive developmental and neurodegenerative disease. Approximately 30% of cases are caused by mutations in the ERCC8/CSA gene. Patients with CS...
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Excited to start the new year with the work of @zawarshahh in its final form! Learn how snRNAs are tra as tuned by RNA Pol II and Pol III and what drives polymerase selectivity!
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Follow us on @alessandrovannini.bsky.social 🙌 really a nice welcoming science community over there!
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tRNAs are important for protein translation, but do they affect #aging? Manipulating #tRNA transcription across 3 animal species reveals unexpected roles for #tRNA in #proteostasis, old-age health & #longevity @IHAatUCL @colinselman1 @worm_ukc #PLOSBiology
https://t.co/PhV4eT8yEq
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Very pleased to share our work on the polyadenlyation-independent termination of Pol II by the helicase Sen1. https://t.co/vfQiAdDklZ Extremely grateful to the generous freedom and support of Patrick @mpgpresident for developing this work. A short 🧵 below.
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Daniel is 18 years old Sunday. A gentler soul you will never meet. He has no friends as he won’t leave home and can’t work. Autism does that to you. Please wish him a happy birthday and RT everywhere . ❤️#happybirthdaydaniel
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Thalia Toseland with the help of her father @ChrisToseland is fundraising for Brain Tumour Research. Check out their @JustGiving page and please donate if you can. Thank you! #JustGiving
justgiving.com
Help Chris Toseland raise money to support Brain Tumour Research
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Good to be back In London to celebrate 25 years of Structural Biology @ICR_London
https://t.co/LTkZlcV3xF
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I am truly humbled to be asked to speak at a @TEDxLakeComo event in November
Genetista umana e responsabile del Centro di Ricerca Genomica di @humantechnopole, nonché professoressa di Genetica Umana @cambridge_uni, @nicolesoranzo ci guiderà alla scoperta delle opportunità rivoluzionarie offerte dalla ricerca sul genoma umano. #TEDxLakeComo #innovazione
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Really cool! We also suspect there might be more functional partially assembled complexes in cells
We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations. Read more at @biorxivpreprint: https://t.co/nVwbVDEJn1
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Read this wonderful tweetorial by the incredible @zawarshahh ! Hard work and resilience always pays off ! Such a nice story that finally reveals Pol II vs Pol III selection at snRNA promoters
🚨 PREPRINT ALERT 🚨 Excited to share our latest from the brilliant @VanniniLab! We uncover structural insights into the unique mechanisms driving RNA Pol II and RNA Pol III recruitment at snRNA promoters. A thread ... #RNA #PolII #PolIII
https://t.co/8zXMqCp5vA
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🚨 PREPRINT ALERT 🚨 Excited to share our latest from the brilliant @VanniniLab! We uncover structural insights into the unique mechanisms driving RNA Pol II and RNA Pol III recruitment at snRNA promoters. A thread ... #RNA #PolII #PolIII
https://t.co/8zXMqCp5vA
biorxiv.org
RNA polymerase III (Pol III) is specialized in the transcription of short, essential RNAs, including the U6 small nuclear RNAs (snRNAs). At U6 snRNA genes, Pol III is recruited by the snRNA Activat...
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A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 May 28th to 30th, 2025 - Save the date! @OscarLlorcaCNIO @rfleiro @NogalesLab
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