Systems and signals group at @ImperialMaths led by Nick Jones. Stay tuned for our latest research on #mitochondria #aging #genetics #biomathematics #physicalbiology #networks and #ML. We blog regularly https://t.co/OP2yt4PBI5 and there's more info at

Our paper 'Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species' https://t.co/o4eb5WWzlM now out in Nature Communications. See our thread on bsky

We will begin the switch over to other social media and have a blueskye account @syssig.bsky.social

Calorie restriction (CR) is known to improve healthy ageing and we find indications that CR rats have lowered levels of cryptic mtDNA mutations. CR can increase mtDNA numbers and our theory predicts that higher mtDNA copy-numbers slow accumulation of mtDNA mutations. 6/6

Over 7 datasets, in multiple tissues in humans, mice and rats, cells with cryptic mtDNA mutations have gene expression changes consonant with ageing including immune effects and protein misfolding. We give experimental corroboration in human cell lines. 5/6

The accumulation of mutations is nonlinear with a phase coinciding with mid-late life where mutations hit high levels. By late life ~a third of all cells have a mutation that has taken over the whole population. Our inferred mutation rate is consonant with literature values. 4/6

We developed theory to account for the accumulation of these mutations and a hierarchical Bayesian inference framework to fit our models. We find that the accumulation of mutations conforms to our theory. We can predict an individual’s age from their levels of mutation. 3/6

We find evidence that a mutation type, invisible in bulk, cryptic mtDNA mutation, makes up the majority of mtDNA mutations in aged post-mitotic tissues. Notably these mutations show weak evidence of negative selection despite many mtDNA mutations having physiological effects. 2/6

We decided to readvertise our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' 1/6 https://t.co/U3xtE5qT2p

🌟 Six 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London (offered through @imperialcollege Research Fellowships). 🗓 Deadline: 19 August 🔗 Read about the fellowships ➡ https://t.co/W7qkBrrDs5 3/3

🌟 Ten 2-year Independent Fellowships dedicated to AI in Science in a program supported by @schmidtsciences: ➡ Eight 2-year Eric and Wendy Schmidt AI in Science Postdoctoral Fellowships. ➡ Two 2-year Chapman Schmidt Fellowships. 🗓 Deadline: 20 September 2/3

📢 Job Alert: 16 Independent Fellowships in AI in Science! The @IX_AI_SciCentre seeks 16 new fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences. How to apply: https://t.co/Dp3K15B0Yk 1/3

A fun video introducing I-X https://t.co/KleC4u3CN2 @ImperialX_AI @IX_AI_SciCentre

Please circulate: new I-X lectureship in I-X and Imperial Statistics: https://t.co/8Am6dVfASs @ImperialX_AI learn about I-X here

Work by @olivercliff @AnnieGBryant @NaoTsuchiya @jlizier published today in @NatComputSci ! Article link: https://t.co/XOxPeSmAKi And thanks to @jkbren for a really clear and thoughtful commentary:

Work by @FerdinandoInsa1 on boosters for COVID19 versus Delta/Omicron, with great @UKHSA collaborators. https://t.co/DktqvFNkOc Boosters work, but protection wanes in ~4 months highlighting the need for continuous monitoring of vulnerable people and for correlates of protection.

📌JOB VACANCY: Senior Teaching Fellow We are looking for a Senior Teaching Fellow who will have a key role in the training of the @IX_AI_SciCentre Fellows and developing our educational programmes within I-X. Deadline: 26 Oct Apply below⬇️ https://t.co/Y3GCZfNVx2

📢11 new independent Fellowships in #AI in #science are now open for applications👏 Don't miss out on this fantastic opportunity to be at the forefront of @imperialcollege #AIresearch 🤖 ⬇️Find out more & apply https://t.co/Dp3K15B0Yk @ImperialAI @ImperialDSI @ImperialSci

@SchmidtFutures @ImperialX_AI Coming Soon... Launching in August, there will be a further round of up to 8 two-year #AI in Science #fellowships. These are flexible & independent and you will be joining a cohort of top scholars based in @ImperialX_AI! Keep an eye out here ⬇️ https://t.co/5OprAOvrOD

Applications are now open for 3 independent 4-year fellowships dedicated to #AI in Science & supported by @SchmidtFutures Based in @ImperialX_AI, these prestigious Imperial College Research Fellows will be given bespoke training & 121 career development https://t.co/B6oOz6wVbG

An exciting AI in Science themed independent fellowship for two years joint between the African Institute of Mathematical Sciences in Kigali and Imperial. @ImperialX_AI @AIMS_Rwanda