mithunmittir
@mithunmittir
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Life. The Universe. Everything. https://t.co/SQenqV6O5I All opinions personal.
Joined September 2019
Our latest paper to wrap up the year. We propose that intersegmental jumps that leverage looped conformations of chromatin can lead to efficient search. Read the preprint at: https://t.co/pqmNic2gl0 Led by @DuttaShuvadip & Adarshkrishnan. Fantastic collab. with @ranjithpa (1/4)
biorxiv.org
We investigate the role of compaction of chromatin domains in modulating search kinetics of proteins. Collapsed conformations of chromatin, characterised by long loops which bring distant regions of...
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Our new work is now out in @softmatter! Depending on the nature of barriers, barriers can speed up transport! Beautiful experiments by @MoumitaDasgup12 and theory by @SougataUtd
https://t.co/PPdxg2JBGr
How do first passage times across a heterogeneous region with multiple barriers depend on the number of barriers? Our new preprint: https://t.co/Vf2ImKVM6h Beautiful experiments by @MoumitaDasgup12 & Leon Armbruster, and analytic results by @SougataUtd & Dibyendu Das. (1/6)
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
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Relationship between chromosomes (orange) and the mitotic spindle (green) in four stages of cell division, as seen by Bessel Beam plane structured illumination microscopy https://t.co/Z5NRQOoi4q
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It was great hosting you @richardwhite321, and thanks for the wonderful talk!
It was really inspiring to be at @iitbombay today and see their excellent work creating the National Disease Modelling Consortium. A bunch of dedicated and talented modellers, computer scientists, epidemiologists, statisticians, social scientists, and admin staff - linking into
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Multivalency regulates chromatin collapse and reswelling through two mechanisms. Congratulations @SougataUtd
PREPRINT ALERT‼️My 1st solo work is out where I study the effects of valencies of multivalent proteins & chromatin monomers on chromatin conformations. Special thanks to @mithunmittir for constant encouragement & feedback,thanks @DuttaShuvadip for feedback https://t.co/wilG2phIAY
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For anyone curious about nonlinear dynamics and chaos, including students taking a first course in the subject: My lectures are freely available here.
youtube.com
This course of 25 lectures, filmed at Cornell University in Spring 2014, is intended for newcomers to nonlinear dynamics and chaos. It closely follows Prof. ...
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Imane Khalif. Legend. ❤️🥹🥇 haters can keep crying like they did with Serena Williams for years.
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Aristotle was the first to notice honeybees dancing. In 1927 Karl von Frisch decoded the waggle. How it works was "explained" by MV Srinivasan AM FRS in the 1990s. Except @NeuroLuebbert found his papers are junk. A 🧵 about her discovery & our report: https://t.co/K0rpDPnfop 1/
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And it really did feel like it!
Reposting this story with a new information that Thane and Mumbai had ‘feels like’ temperature of > 50degC yesterday.
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I keep reminding PhD students that THE most important outcome of a PhD is not their publications, conferences, awards etc., but they themselves after this journey. PhD is a learning process in how to learn new things, solve new problems you run into. @VoicesofIndAcad @biopatrika
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Do participate in this meeting on the Interdisciplinary aspect of chromatin organization and gene regulation at ICTS Bangalore (@ictstifr) in September 2024. Pedagogical workshop + conference. Register here: https://t.co/8hGp9mpsRs
@DimpleNotani @mithunmittir
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Last couple to days to apply to this exciting workshop! Apply by April 28th: https://t.co/qQ7OkC6IIs
IMSc announces a 2-week workshop on mathematical modeling of development in biology, Flags, Landscapes, Signaling: From gene regulatory dynamics to tissue patterning & morphogenesis, during May 6-17, 2024. To apply, visit https://t.co/iWLT9lWTqW
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A terrifying indictment of neoliberal capitalism https://t.co/3oGecMgB9A
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My group is looking for Ph.D. students in the Physics of Biological Systems. We apply statistical physics principles to study living systems using a combination of analytical theory and simulations. Apply here: https://t.co/V8ciTtBK6V More info at: https://t.co/Jfs5xftSdf
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📢 We're thrilled to announce the 9th edition of our Annual #MonsoonSchool - #PhysicsOfLife2024! 📅 1-10 July 2024 | @NCBS_Bangalore 👥Open to 2nd year undergrads & above ✍️🏽 Register by 15th April: https://t.co/3Y5O9ogxsO 💻 Read more: https://t.co/8YXHwBQtpa
#PhyOfLife24
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I've taught a Physics of Biological Systems course for some years now at IIT Bombay. These lectures were recorded in 2018 and are available on youtube (+ NPTEL), for any interested students. https://t.co/opIISAvlNq NPTEL: https://t.co/PO52CDWbYH This has been a PSA :)
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This is one reading list worth saving
1/n: There are some academic papers that are so brilliantly and so accessibly written and so universal in scope that they transcend disciplines and stand as timeless testaments to both great thinking and great writing. Here's a short personal selection:
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Muthu in full flow!
When Professor Muthukumar works out every bit of the phase separation theory of polymers in a workshop we organized @iitbombay; @mithunmittir @mbuanand @SamirKMaji1 @DuttaShuvadip @vinoth46m
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There exists an optimal polymer compactness that minimises search times. Experimental Hi-C data shows that TADs (collapsed chromatin domains) lie near this optimal compactness zone, suggesting a coupling between chromatin structure and search kinetics. (4/4)
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“Intersegmental transfer”– where searching proteins leverage looped spatial conformations of chromatin to access distant genomic regions–offers a viable search strategy. Using theory and simulations, we show that search times depend non-monotonically on polymer compactness. (3/4)
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