Mia Hamilton
@miahamilton5
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Duke PhD Candidate | Colby '19
Durham, NC
Joined February 2012
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER
cell.com
In this manuscript, Liu and Hamilton et al. experimentally characterize ambient gRNA library noise in perturb-seq screens; identify factors influencing ambient gRNA noise; develop CLEANSER, an...
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Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER https://t.co/bvkIE0NnXP
#biorxiv_genomic
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For a full tutorial on CLEANSER, including how to use CLEANSER with Cell Ranger outputs, visit our GitHub 🙌
github.com
Contribute to Gersbachlab-Bioinformatics/CLEANSER development by creating an account on GitHub.
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🚨 Preprint alert! 🚨 Check out @sussan_liu and my open source gRNA assignment tool, CLEANSER, for assigning gRNAs to cells in perturb-seq screens 🎉
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🚨Our work on multi-modal, single-cell pooled CRISPR screens to study GWAS variant-to-function, STING-seq, is now out in @ScienceMagazine! Read on for 6⃣ of the main findings from our study, led by myself and co-advised by @nevillesanjana and @tuuliel! 🎉 https://t.co/0LUM3m40v3
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Beyond excited to announce that I passed my preliminary exam! Grateful for the support of my committee, mentors, and loved ones. Looking forward to the next stage of my research journey. #PhDcandidate 🎓🎉
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Systematic elucidation of genetic mechanisms underlying cholesterol uptake
cell.com
By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, Hamilton et al. improve the identification of genes whose disruption...
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So honored to have been a part of this work in the @SherwoodLab! Take a look at our #tweetorial below 👇👇👇
We are excited to share our latest publication in @CellGenomics by @miahamilton5 et al. https://t.co/CT5u1EddiY
#Genetics #CRISPR #tweetorial 1/16
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Exciting news in genetics & heart health! New work from our lab identifies 21 genes that significantly impact LDL cholesterol levels & contributes to coronary artery disease risk. Learn more in the paper: https://t.co/qfbCSUf6ku
#genetics #heartdisease #LDL
biorxiv.org
Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-C...
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Join us next Thursday (Nov. 17) for a student-led webinar focused on de-mystifying the Ph.D. application process! Learn about application materials, choosing a program, and more. Register at https://t.co/dh5I0fNHeI.
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At last week’s welcome picnic we awarded @miahamilton5 and @AnushkaKatikan2 the annual award for student excellence in memory of Dr Marcy Speer. Congratulations!
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Lab outings are a thing again!🥳Big loss for our group as two outstanding researchers,@miahamilton5 n Minsun, leave our lab to start their PhD, but big win for @DukeU and @JohnsHopkins.Thanks for your hard work and contagious positive energy!Good luck with your scientific career!
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Using CRISPR to understand and manipulate gene regulation A Review by Ersin Akinci, Marisa Hamilton, Benyapa Khowpinitchai & Richard Sherwood @SherwoodLab
https://t.co/h8TfrKsxE9
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Newest @biorxivpreprint from our lab on mediators of remdesivir host cell cytotoxicity. https://t.co/Y9COLiJJfS
biorxiv.org
The adenosine analogue remdesivir has emerged as a frontline antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness[1][1]. Prior clinical...
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Read about the work that has been done in our lab at @BrighamWomens @BrighamResearch on #COVIDー19 and evaluating potential treatments in the fight against the #virus #Remdesevir #hydroxychloroquine #covid19MA
https://t.co/Rw6Vny6Yga
bwhclinicalandresearchnews.org
When Richard Sherwood, PhD, convened his lab for a virtual meeting to discuss how their research would continue during the…
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We don't know how best to reopen the country, but we have a playbook https://t.co/0x8I9L3zzS
#CoronavirusUSA #COVID19 #COVID #SARSCoV2 #OpEd
thehill.com
It’s prudent to draw on the lessons learned by the medical field as we sail through uncharted policy waters over the next few months.
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A new blog post is up on our site! Read about how we plan to establish a biosafe assay for #SARSCoV2 RdRP activity: https://t.co/upCxY7WHxS
#coronavirus #COVID19 #COVID2019 #Covid_19 #CoronavirusPandemic #COVID
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Like so many people around the world, the members of our lab have been following the spread of the coronavirus pandemic and wondering whether we can help out in any way. None of us are doctors. The science we think about on a daily basis doesn’t concern infectious... (1/3)
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The lab I work in is currently studying the genetics of toxicity of candidate COVID-19 drugs. Give us a follow for updates on our research and relevant coronavirus news! #COVID19 #coronavirus #CoronavirusPandemic
We are the Sherwood Lab operating out of Brigham and Women's Hospital and Harvard Medical School. As a genomics lab, we have begun working on understanding the genetics of toxicity of COVID-19 drugs. Follow us for updates on our ongoing #COVID19 research.
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