1/ Delighted to be listed among this team for this paper, which is now published. I would like to Thank Dr Wenzhong Xiao and @OpenMedF for this collaboration. Some comments about this work :

I rarely make posts like this one, but yesterday I was at this beautiful spot and felt grateful for being able to do so. Not long after, I thought about all of those patients who are unable to have a normal life. No stopping until a solution is found. #MECFS #LongCOVID

RT @SpichakSimon: For @thesicktimes I dug into Canadian Long COVID guidelines that experts called "contradictory" and "deeply concerning."….

4/ Please note : This thread is not a suggestion to supplement with LOLA.Please talk with your doctor for testing ammonia levels in your blood if possible.

3/ The reason for trying LOLA back then, was because there was an increase on some of my symptoms when I would eat lots of protein. This is also discussed in my recovery story :

3/ . using a different LOLA supplement brand from the one I used. In 2019, I did not have many buying options for LOLA (which is used for hepatic encephalopathy). I can definitely now say it is working for me. Total dosage is 2 grams / day, spread in 4 doses.

2/ . did not seem to "feel" right for me. I did not feel unwell but I had some strange lightheadedness after taking it so I decided not to move forward in further supplementing it. Given our recent publication (see below) & patient comments I decided to try it again, this time.

1/ I would like to share my personal experience with LOLA (L-Ornithine / L-Aspartate) supplementation and also an update from using it. When Dr Wenzhong Xiao first mentioned it to me, I told him about my first experience from using it which was in 2019. Back then, LOLA . .

How AI reasoning could change Healthcare :

5/ Personal opinion : Given the latest study by Ponting et. al which mentions potential liver dysfunction, this study could also be yet one more "signal" that liver function has to be further investigated.

4/ Asparagine is required for proper N-Linked glycosylation. Personal opinion : The function of N-Linked glycosylation should be further investigated in patients and whether low asparagine levels can be responsible for ER Stress (ER Stress identified in a study by Hwang et. al).

3/ We have more than one studies that identify a potential down-regulation of the Urea Cycle (also seen at latest study by Ponting et. al and Armstrong et. al ) . Urea cycle was also identified through Network Analysis in 2017 ( Network Analysis figure shown below, unpublished)

2/ A number of metabolic disturbances have been found including down-regulated alanine / aspartate metabolism & arginine / proline metabolism, decreased urea cycle secretion and up-regulated pentose phosphate pathway.Asparagine was the top down-regulated metabolite after exercise.

Based on my latest blood results, I witnessed a profound decrease (-59 mg/dL) within 2 months in my LDL cholesterol levels without any significant dietary interventions (cc @tamararivc). Certain actions based on a personalized plan is most likely responsible for these results.

It was the same for me , it took me months to accept I got over #mecfs . I hope this continues for @Gmwetz.

RT @wigglethemouse: I was one of those who got so much worse while on anti virals. I became severe and the clinic abandoned me. 8+ years ho….

RT @davidasinclair: What’s up with Taurine? New @biorxivpreprint suggests elevated taurine caused by caloric restriction serves as a hormet….

RT @Gmwetz: I would like to retweet @tamararivc ME hypothesis in case you haven’t seen it yet. Please see below. It would be nice if more….

RT @DanMissailidis: Bear with me here. People with ME/CFS, have you been found to have an enlarged liver or spleen while having ME/CFS?.

RT @mecfsskeptic: 1) Interesting collaboration between the Iwasaki team and the Bragée clinic in Sweden. Their conclusion: . "when evalua….