Tamara C
@tamararivc
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Published a Long Covid/ME/CFS hypothesis about Phosphatidylcholine, Insulin Signaling and Noradrenergic Dysfunction
London, UK
Joined May 2019
🚨 Big update to my ME hypothesis! . I've revised my paper to include new insights on the MTHFR gene & how it connects to phosphatidylcholine synthesis. Here’s a breakdown of what’s new: ⬇️. @JanetDafoe @OxMEDiscovery @PutrinoLab .#MECFS #LongCovid .1/25.
www.youtube.com
In the first video of this hypothesis, I proposed that in ME/CFS there is hypersensitivity of noradrenergic neuronal insulin receptors leading to dysregulati...
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RT @lifeanalytics: 1/ Delighted to be listed among this team for this paper, which is now published. I would like to Thank Dr Wenzhong Xiao….
www.mdpi.com
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID are complex multisystem conditions that pose significant challenges in healthcare. Accumulated research evidence suggests...
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RT @vipintukur: A NEW study reports that a high school student worked w/ researcher of University of Victoria to develop #Mobius, a transfo….
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RT @lifeanalytics: 1/ 🧵 I am excited to share the latest results -as a hypothesis- , using computational #AI analysis applied to #MECFS and….
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RT @lifeanalytics: 1/ I am amazed with @genspark_ai and what it could potentially do for medical applications. The reason for my amazement….
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Are there any #pwME who have a genetic test report that they would be willing to send to me so that I can look for gene variants which are connected to my hypothesis?. #MECFS #LongCovid #MyalgicEncephalomyelitis.
🚨 Big update to my ME hypothesis! . I've revised my paper to include new insights on the MTHFR gene & how it connects to phosphatidylcholine synthesis. Here’s a breakdown of what’s new: ⬇️. @JanetDafoe @OxMEDiscovery @PutrinoLab .#MECFS #LongCovid .1/25.
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Exercise leads to histamine release from mast cells #MECFS #LongCovid.
Cellular crosstalk in skeletal muscle? A surprising role for mast cells? Histamine as a signal transducer during exercise? This was an amazing ride during my time @TeamDerave, now published in @Cell_Metabolism (1/11). @ugent_fge, @FWOVlaanderen .
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RT @tessfalor: 3 years ago I joined a panel of patients to determine how to allocate $4.8 million to Long COVID, ME/CFS, & dysautonomia res….
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If you did it for 3 weeks and felt better at least you would know that prostaglandins are probably causing your symptoms.
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I’d love to hear your thoughts! Have you noticed any of these components in your own case? Let’s discuss!.@TomKindlon @ABrokenBattery @Z3R0Gravitas @RenegadeRes @PaulRKeeble @RorPreston @BottsieHicks @DafoeWhitney @Gmwetz @Fighting_LC @lbalombini @TaraFotiPhD @KatBoniface .25/25.
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This hypothesis revision integrates new research & refines the core mechanisms of my original hypothesis. To read the revised paper select ‘Version 2’ on the link below & download the PDF-. @LisaAMcCorkell.@ahandvanish @chydorina @Canal1point5 .24/25.
www.preprints.org
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease characterised by profound fatigue, post-exertional malaise, and multi-systemic dysfunction. This hypothesis...
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Example 2: Supplementing PC without reducing liver fatty acid synthesis could increase circulating triglycerides and lead to insulin resistance developing. 23/25.
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Personalized Treatment Approach:. If you treat only one component, others may remain unaddressed, causing new or worsening symptoms. Example 1: PC supplements help some, but if PLA2 is overactive, it may increase prostaglandin-related symptoms. 22/25.
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5️⃣ Mast Cell Activation. Even if mast cell activation is a downstream effect it could further worsen the PLA2 activation and liver dysfunction, so needs to be treated in order for a patient to recover. @cstroeckw @hmkyale . 21/25.
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4️⃣ Norepinephrine dysregulation. 20/25. @Gmwetz @Michaeltikus #MyalgicEncephalomyelitis #pwME #LongCOVID #MECFS
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1️⃣ Phosphatidylcholine dysfunction (synthesis, transport, membrane uptake). @doctorasadkhan @dbkell @Sunny_Rae1 @LBatemanMD @DrMark_Faghy . 17/25
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Multiple Components: . Instead of looking for a single cause, patients need to evaluate which components are driving their illness. The five major components are:. @VirusesImmunity @MichaelPelusoMD.@MBVanElzakker @microbeminded2 @Naomi_D_Harvey.@CiaraGlenville . 16/25
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Mast cell activation can lead to PC breakdown via COX-2. It can also increase SREBP-1 activation in the liver. But it can also be a downstream effect due to prolonged norepinephrine elevation and β2-adrenergic receptor downregulation on mast cells. 15/25.
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Dysfunction of norepinephrine signaling would affect cognition, sleep-wake cycle, the glymphatic system, glucose regulation, blood flow control, and Sympathetic Nervous System regulation, explaining many of the symptoms of ME. @LBatemanMD @vijayiyer312 .@rfrosencrans .14/25.
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