Xin Sun Lab
@lab_xin
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Official Account for Dr. Xin Sun Lab at University of California, San Diego. Everything lung related!
Joined April 2020
Online Now! Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells https://t.co/5b0mMYJlrE
#stemcells
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Check out our latest study on mitochondrial regulation of airway cell fates and behaviors. The respiratory organelle in the respiratory cells are almighty! https://t.co/c0EPOCNNIn
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Touching stories in front and behind the paper Neural circuit underlying asthma reinforces the lung’s role as a sensory organ
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Wondering how neural circuits control allergen-induced airway hyperreactivity? Check out our latest study published on @Nature
https://t.co/Xvdpbc4ovB
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No twitter for quite a while, until this must twitte! Newborn center with a mature lung. Thank you every one for joining us. Can't wait to see how the UCSD Center for Lung Biology grows and regrows. @nih_nhlbi @UCSDHealth
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Excited to share that our paper on injury-induced lung tuft cells is out now in @eLife! This is the fruit of an awesome collaboration with @lab_xin. Congratulations to the all authors, especially co-first authors @barrjamie and Marilena Gentile! https://t.co/WOs4A8YE54 (1/2)
elifesciences.org
Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
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Preview in this issue of Dev Cell: The elusive pulmonary neuroendocrine cell: How rare diseases may help solving common diseases -
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Excellent work from amazing graduate student in the lab @JinhaoXu1729! Detailed dissection of the genetic, molecular and cellular phenotypes downstream of a Neuroendocrine hyperplasia-causing NKX2-1 point mutation modeled in mice.
Article in this issue of Dev Cell: Excess neuropeptides in lung signal through endothelial cells to impair gas exchange -
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Thrilled to share our collaborative story with @lab_xin, led by the incredible @barrjamie and Marilena Gentile. Lung tuft cells are enigmatic little guys, and many of the rules they follow in the intestine don't seem to matter much in the lung! And a big assist from @KotasMaya
Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair https://t.co/YJB2wZUZHd
#bioRxiv
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Identification of lung innervating sensory neurons and their target specificity in a new #ResearchArticle by Yujuan Su and colleagues from @lab_xin, @UCSDMedSchool, and @ucsdbiosciences: https://t.co/OkZYFH8dx4
#VagalGanglia #innervation #interoception #ArticlesInPress
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Excited to be working with @Perl_anne @lab_xin @RoryMorty @semilc and @MwaseChimwemwe to program an outstanding GRC and GRS @GRClung2021
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Our browser to interact with single cell genomic data from the human lung and help interpret genetic risk of COVID and other lung disease, w/ @KudtarkarParul @YingSun_UCSD @Sharvari__N @CEpigenomics @lab_xin
https://t.co/hsU7XM0z6T
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“We suggest excluding this reviewer because of an obvious conflict of interest”
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(1/6) Excited to share that our OligoFISSEQ paper is up ( https://t.co/cjkudjiu7z)! We set out to develop single cell in situ #3Dgenome mapping methods. A fun collaborative effort led by @huy_sauce @ShyamtanuC and David Castillo, from @TingWu_Lab and @mamartirenom groups.
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Spoiled with the bday present from my hubby. He designed and 3D printed me a cell biologists ultimate chess set! 😍
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Very excited to share SHARE-seq - single-cell ATAC+RNA in the same cell - with you! Using the paired data we find that chromatin change can predict future gene expression states! Enabling opportunities to define cell trajectories and their regulation (1/2)
biorxiv.org
Cell differentiation and function are regulated across multiple layers of gene regulation, including the modulation of gene expression by changes in chromatin accessibility. However, differentiation...
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Excited to share our latest work on #LSD1 and epigenetic enhancer silencing in #pancreas and #islet development @NatureComms. Incredible effort by graduate students Nick Vinckier, Nisha Patel, and Ryan Geusz. A short summary to come: 1/7 https://t.co/bSYUQYsYM6
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Excited to share this preprint with the community! A fantastic effort from everyone involved. A great first highlight for Twitter!
Excited to share our SARS-CoV-2 preprint! Using snRNA-seq and snATAC-seq, we - in a truly collaborative effort w/ @lab_xin and @kjgaulton - investigated the expression and regulation of SARS-CoV-2 host genes in the lung during aging. https://t.co/cWkqzNRe5r
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