We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. 1/10

RT @AydoganLab: EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development. How did we even get here. ?….

RT @ElphegeNoraLab: First preprint from the lab 🚨. How can enhancers regulate target promoters across vast genomic distances, and what is t….

RT @ReiterLab: Please read and critique our new paper on the genetic determinants of human kidney function @NatureGenet:..

Check out this nice writeup of our recent paper and the field at large. @WalentekLab identifies some of the most interesting outstanding questions!.

RT @scdb2024: The 2024 Santa Cruz Developmental Biology meeting is just 9 days away and counting! Peruse the full #scdb2024 talk schedule,….

RT @TatsuyaTsukui: Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in @Na….

RT @UCSF: UCSF scientists have unexpectedly discovered that the cell cycle - which enables cells, like stem cells, to divide – can also spr….

RT @cavankatenaugh: Are you going? I know I'm applying!.

A great team made this project really fun to work on – especially Lauren Byrnes and @ReiterLab. Big thanks to @KonjikusicMia, Benedict Tsai, Rachel Deleon and collaborators Quanlong Lu and Chris Westlake! 10/10.

With the multiciliation cycle, there are now at least four major cell cycle variants. Maybe the cell cycle is redeployed in other contexts to regulate differentiation as well? Check out the paper for more details and data: 9/10

Check out beautiful recent work from the Meunier lab exploring the role of cyclin O (a non-canonical cyclin) in this alternative cell cycle: ( . 8/10.

The multiciliation cycle is a terminal cycle that amplifies centrioles while repressing DNA replication. This is akin to cell cycle variants like the endocycle in which DNA replication is enhanced or the meiotic cycle which has an extra round of cytokinesis. 7/10

We identify cyclin D1-CDK4/6 as a novel regulator of entry into the multiciliation cycle and differentiation initiation. We also show that E2F7, a repressor, prevents DNA replication in differentiating multiciliated cells. Mice lacking E2F7 show defects in multiciliation! 6/10

Many labs have shown that individual mitotic regulators are involved in multiciliated cell differentiation. We show that these individual regulators are organized into a cell cycle-like network that coordinates multiciliated cell differentiation, not cell division. 5/10

We found that across the stages of differentiation, multiciliated cells express regulators of the mitotic cell cycle – CDKs and their paired cyclins. But these cells are post-mitotic. Why do terminally differentiated cells express regulators of cell division? 4/10

Most cells can only make 2-4 centrioles. Multiciliated cells generate hundreds (!) of centrioles, to make the necessary cilia at the cell surface. How do these cells make 50x the normal number of centrioles?!? 3/10

We call this new cell cycle variant the “multiciliation cycle”, for the specialized multiciliated cells that it generates. Multiciliated cells form hundreds of cilia which beat to move fluids, for instance to clear mucus and pathogens (like SARS-CoV-2) from the airways. 2/10

RT @RosenblattLab: After ~12 years of hard labor, lots of push back and excitement, we are pleased to present our paper showing a new mecha….