Kevin Xiang lab
@kevinyxxiang
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We are interested in fundamental neurohormonal regulation in heart and brain diseases.
Davis, CA
Joined June 2020
Brian gave an excellent talk on “challenges and new approaches on GPCR drug discovery”.
A great day with Brian in town for the 2nd Krebs Symposium! It is amazing for the whole lab to share the exciting moment.😀😀🎉🎉
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A great day with Brian in town for the 2nd Krebs Symposium! It is amazing for the whole lab to share the exciting moment.😀😀🎉🎉
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Glad it is out! Really a tour over 2 years!
New Review by Fu et al. @UCDAVISPharmac1 discusses the current understanding of the complex regulation of PDE isoforms in #cardiovascular function, highlighting divergent and even opposing roles of PDE isoforms in different pathogenesis. https://t.co/ISiNB7xp9K
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A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium... - https://t.co/4mJ4s36v3m
#ScholarAlerts congrats to the team @SMarxLab
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Just out in @ESC_journals our paper led by Qian Shi, @LongShengSong1 & Ethan Anderson, @Iowamed @IntMedatIowa elucidating the mechanisms for an anti-arrhythmic effect of MAO-Inhibition. Treating depression and heart disease with one drug?
academic.oup.com
AbstractAims. A mechanistic link between depression and risk of arrhythmias could be attributed to altered catecholamine metabolism in the heart. Monoamine
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α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity: Cell Reports
cell.com
α-Synuclein (α-Syn) aggregation is a key feature of neurodegenerative disorders like Lewy body dementia and Parkinson’s disease. Horvath et al. demonstrate that α-Syn fibrils or disease mutations...
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Congratulations, we will miss you!
The Tian Lab is moving! After many wonderful years at @ucdavis, I am embarking on a new journey as a Scientific Director at @MPFI. It’s bittersweet to say goodbye to the wonderful community at Davis, but I’m excited about the challenges & opportunities in my new role.
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Contact yulonglilab2018@gmail.com if you want to try these new sensors in advance. Find more information on resource at https://t.co/HPc2zltpJM.
Excited to introduce our optimized green and red fluorescent dopamine (DA) GRAB sensors #GRABSensors #dopamine Great collaboration with Mitsuko Uchida‘s group at Harvard University, Yingjie Zhu’s group at SIAT, John Williams’ group and Marina Wolf’s group at OHSU.
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Ageing can be quite nerve-wracking! This is especially true for the old heart. See my very first Science paper to learn more! 😎 https://t.co/NtZjZgWWNj Thanks so much for this massive team effort @InstCardReg_FFM @StefanieDimmel1 @gluxan @th3k4ty
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In-press preview @jclinicalinvest: Our latest work demonstrates the mechanistic link between #CKD and #Afib pathogenesis via the #NLRP3 inflammasome. Neutralizing #IL-1β antibodies might offer benefits in preventing AF induced by CKD. https://t.co/YzOZXvPSgv
@XWehrens
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Looking to fill two NIH-funded postdoctoral positions. Join a vibrant/diverse team doing exciting research on signal transduction and ion channel regulation in neuroscience & cardiovascular biology. Check out my website https://t.co/cvMWFTlTdb. DM or email me if interested.
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We have provided an overview of current and emerging approaches for monitoring neuropeptides, with a focus on GPCR activation-based sensors. We hope that this review will assist scientists in the selection and application of appropriate tools in their research.
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So excited to share our new publication in @NatImmunol! We leveraged new bioinformatics pipelines and a synthetic biology approach to identify a novel GPCR-Gs-PKA immune checkpoint promoting T cell exhaustion and cancer immunology failure. https://t.co/niU3FDDMip
@NCIEytanRuppin
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I want to thank my life partner and wife for her support and that of my family.
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Dress rehearsal before the signing of the @theNASciences register starting in 45 min #NAS160
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Great way to start the week! Our collaborative work with @UCDavisHealth colleagues on "Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain" is out @JExpMed. Major effort from Olga Chechneva @UCDBMM! https://t.co/rguq0O2QL3
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Thanks, Terry for sharing this work! I am glad you like it!
This is pretty amazing!
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This is pretty amazing!
science.org
β2-adrenoceptor activation stimulates the nuclear export of PDE4D5 to promote learning and memory.
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Thank you! Navid, @VicTamez88 @Jadeltaylor19, Yumna, Yaseen, @Rebound_32 , @eric_psilva, Riley, Sophia, Hannah, @mf_navedo,@Miguel_MartinAB . Not in the picture Curtis and Omar.
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