Karthik
@karthik_varanas
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Post-doc at the Salk Institute. I work on how cancer puts on multiple hats to protect from immune insult.
San Diego, CA
Joined November 2016
Thrilled to announce that I will be starting my lab at @UMassChanPII ! It is only possible with the support of extraordinary mentors @Tcellogic at @salkinstitute and B Rouse at @UTKnoxville. Will be hiring at all levels to study tissue-specific immune metabolism. #varanasilab
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@WGoessling This would also not be possible without incredible support from @CancerResearch @nationalcancercenter @nomisfoundation.
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With great joy! I want to share with you our recent work on how Bile acid synthesis impedes tumor-specific T cell responses during liver cancer | Science thanks to all the authors and @Tcellogic @salkinstitute
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VaranasiLab has moved to bsky as well. Please follow for updates. Looking forward to connecting with you all there.
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Phenomenal paper from @Tcellogic to what out for!.
Our platform systematically identifies TF programs across diverse T cell states, facilitating the engineering of specific T cell states to improve tumor control and providing insights into the cellular mechanisms underlying their functional disparities.
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RT @LabWaggoner: Our platform systematically identifies TF programs across diverse T cell states, facilitating the engineering of specific….
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RT @RPWLab: Thrilled to share companion stories from our lab, out today in @ImmunityCP and @CellReports . We characterize an enzymatic TIR….
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RT @JeffRathmell: Congrats to Andrew Patterson for his work using CRISPR screens to find we have vastly underestimated the overlap of Inbor….
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RT @Acyn: Trump: You have to get out and vote. You won’t have to do it anymore. Four years, it will be fixed, it will be fine. You won’t ha….
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CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells | The Journal of Immunology | American Association of Immunologists. Congratulations @PCRosato1 for interesting findings.
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I am extremely delighted to know that @Tcellogic is elected to national academy of sciences #NAS. Super big congratulations!!.
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A phenomenal talk by @Tcellogic at #cicon23 @CancerResearch talking about our new work in @ScienceMagazine on Mitochondrial regulation of tumor immunogenicity.
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This occurs not via direct recognition of antigen by MHC-I or-II but by increasing microglia activation and their phagocytic potential. So finding ways such as anti-CTLA4 to promote CD4 T cell responses could be beneficial to controlling glioblastoma, one of the deadliest tumor.
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We found that the CD4+ T cell driven IFN-gamma but not CD8 T cells inhibits glioblastoma mainly more stem-like glioma ( although more differentiated and mutagenic glioma do respond to CD8+ T cells).
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Our paper is finally out and I am happy to share some main findings here.#glioblastoma #immunotherapy @salkinstitute #cancerresearch
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Super excited to share this work from Janelle Ayres lab. Where they show that CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection: Cell Reports
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