Pukkila-Worley Lab is also @rpwlab.bsky.social
@RPWLab
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Research Scientist. Infectious Diseases Physician. Professor of Medicine. UMass Chan Medical School. Innate immunity, intestinal epithelial cells and worms.
Worcester, MA
Joined May 2017
Thrilled to share companion stories from our lab, out today in @ImmunityCP and @CellReports . We characterize an enzymatic TIR protein as an immune sensor in animals. See tweetorial from @UMassChan @UMassMDPhD student @tse_elegans
https://t.co/u7KXNkJypa
https://t.co/JPRIcp9Wi0
cell.com
Innate immunity across the tree of life requires enzymatic TIR-domain proteins, whose activity is engaged by aggregation. However, it is not known how this protein multimerization is regulated....
Stoked to share our companion stories, now out in @ImmunityCP and @CellReports! We characterize an enzymatic TIR protein as an immune sensor in animals, showing that it is a guard protein in an effector-triggered immune response. https://t.co/BQ42MDdvzx
https://t.co/w6ff47pAdd 1/
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2025 RPW Lab Outing! This year, a hike up Mt. Watatic on a blue bird day. Love our lab!!! :-)
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Read Pukkila-Worley, MD, is the new director of the MD/PhD program: https://t.co/qj36rYHf8M Dr. Pukkila-Worley has mentored dozens of MD/PhD graduate students since joining @UMassChan in 2014. The @RPWLab studies host-pathogen interactions and bacterial pathogenesis. @UMassMDPhD
umassmed.edu
Read Pukkila-Worley, MD, professor of medicine, will succeed Catarina Kiefe, MD, PhD, as the director of the Medical Scientist Training Program.
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Check out the cover of @TrendsImmuno !! Art by lab alumna @tse_elegans to highlight our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! https://t.co/tYg3QoXAp8
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Incredibly proud of @Mo_AliNasrallah , a @UMassChan @UMassMDPhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025
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Excited to share another review from the lab, out this week in @TrendsImmuno . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity!
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Excited to share our recent review out in @NatRevImmunol . We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. @UMassChan
Patterns of pathogenesis in innate immunity: insights from C. elegans
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Absolutely bursting with C. elegans, @UMassChan , @MGHMolBio , Simches 7 pride this morning!!! Congrats Victor and Gary!!!!
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Looking for an up to date review on dna sensors and their role in autoinflammatory diseases check out this review from @Mingqi7up 👇
https://t.co/g4NGgIGbXz I hope this is a helpful review! Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate. Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!
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Welcome Karthik!!!
We are super excited to be welcoming @karthik_varanas to the Division of INnate Immunity @UMassChan this November to start his lab @UMassChanPII ---welcome to @UMassChan @UMassChanGSBS #newPI
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Sharing a nice write-up from @UMassChan highlighting @tse_elegans and her recent companion papers from my lab that were published last week in @ImmunityCP and @CellReports .
umassmed.edu
The two published papers both started with a single question: “What regulates the immune response in C. elegans?”
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Online now: Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles
cell.com
TIR-domain proteins with enzymatic activity are essential for immunity across the tree of life. Tse-Kang et al. show that C. elegans TIR-1 is a guard protein in an effector-triggered immune response,...
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SARM - an enzymatic TIR protein. Perhaps the most ancient immune regulator in the Tree of Life and the origins of innate immunity itself. But, is it an immune sensor in animals?
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Join us! My lab @UMassChan is seeking postdocs and research associates who are passionate about how changes in metabolism and epigenetics contribute to cancer development and immune system evasion. DM me for a chat and apply at https://t.co/VlYVMhYDVD (postdoc position)
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Kicking off #MAPSS2024 in Madison! Many thanks to the organizers @phillips_lab @RPWLab @TheDouglasLab for all their efforts to bring us together. Looking forward to connecting with old friends and hearing some fantastic science over the next few days!
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This is SO HUGE!! An incredible story from a super talented graduate student. I have loved watching the story come together at our monthly Innate Immunity Data club. Congratulations @JustKOS1 and @VirulentMind @UMassChanPII is very proud of you both!!
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A huge and special day for the lab. @nick_d_peterson accomplished so much as an @UMassMDPhD student, culminating in the Chancellor’s award for the top medical student in his class. He is bound for astronomical success as a physician-scientist. I am beyond proud #UMassChan2024
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