Kijun Kim
@k1jun_
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EMBO Postdoctoral Fellow @ChirlminJoo_Lab | Next-Generation Single-Molecule Biophysics | Antigen presentation | RNP complex | CRISPR | Non-coding RNA | RNAi
Delft, Netherlands
Joined July 2021
Do you want to perform single-molecule fluorescence measurements of thousands of different sequences in one go? Good news, our detailed protocol for SPARXS is now out in Nature Protocols! https://t.co/TX517VZpr8
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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The structural landscape of Microprocessor-mediated processing of pri-... https://t.co/uxbopfup2u Ankur Garg's beautiful work on how the Microprocessor tackles the diversity of pri-miRNAs is out! Thanks also to Renfu Shang, Todor Cvetanovic and @lucksmith! @CSHL @HHMI
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🧬Examining DNA molecules was a slow process. Biophysicists developed a technique that speeds up screening of individual DNA molecules at least a thousand times. They can measure millions of DNA molecules within a week instead of years to decades. 👉 https://t.co/FPXMfkW1H0
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After years of development, we proudly present SPARXS in @sciencemagazine. By combining single-molecule fluorescence microscopy with next-generation sequencing, large sequence libraries can now be studied at the single-molecule level! https://t.co/M4IgCN1GZ8
science.org
At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but...
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Happy to share our exciting findings on cell surface RNA. Heparan sulfate acts as a scaffold for RNA & RBPs to orchestrate receptor-ligand interactions. I was fortunate to be part of @ChirlminJoo_Lab to carry out this work as part of my postdoc research. https://t.co/jotWl3utk2
biorxiv.org
Recent discoveries have shown the presence of RNA molecules on the cell surface, defying the traditional view that RNA only functions intracellularly. However, it is not well understood how cell-su...
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It’s heparan sulfate again?! In my post-doc research at @ChirlminJoo_Lab , we demonstrate heparan sulfate acts as scaffold to present RNA and RBP on cell surface. The three biomolecules work together to modulate cell-surface receptor-ligand interaction. https://t.co/OZbEu7HTN6
biorxiv.org
Recent discoveries have shown the presence of RNA molecules on the cell surface, defying the traditional view that RNA only functions intracellularly. However, it is not well understood how cell-su...
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Doctoral degree in the pocket 🥳 Thanks to all committee members for the nice discussions, all collaborators for the cool projects, and Chirlmin and all lab members for the great time in the past few years!
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RNA-guided RNA silencing by an Asgard archaeal Argonaute @fabaiwu @DCSwarts @ChirlminJoo_Lab @C_Bastiaanssen @pilar_bobadilla @k1jun_ @FinocchioGiada
#Asgard #archaea #RNAsilencing #Argonaute #evolution
https://t.co/BFLqvlDE5A
nature.com
Nature Communications - Eukaryotic Argonaute proteins participate in RNA-guided RNA silencing pathways and are divided into AGO and PIWI clades, with functional and mechanistic differences. Here,...
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My work in previous lab is finally published!
Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle https://t.co/qWqQPVNslR
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It's a great joy to witness the wonderful collaboration and to be a part of it. Thanks to all the groups involved!
Paper out today: “RNA-guided RNA Silencing by an Asgard archaeal Argonaute”. A wonderful, multidisciplinary project co-led with @DCSwarts @ChirlminJoo_Lab, spearheaded by @C_Bastiaanssen @pilar_bobadilla @k1jun_ @FinocchioGiada & Yanlei Feng. https://t.co/Yh3wXAYFc3
@NatureComms
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Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle https://t.co/qWqQPVNslR
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Atomically accurate de novo design of single-domain antibodies https://t.co/HGvmJVfY9Y
#bioRxiv
biorxiv.org
Despite the central role that antibodies play in modern medicine, there is currently no way to rationally design novel antibodies to bind a specific epitope on a target. Instead, antibody discovery...
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If you have been working or plan to work on #glycoRNA, please spend some #glycotime through this thread, because it is worthwhile knowing the risk you may encounter.
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Watch out, glycoRNA community for the risk! You might be looking at a completely different molecule even following the same isolation procedure. Run the checkpoint experiment to check if it’s glycoRNA! #glycotime
biorxiv.org
A recent ground-breaking study suggested that small RNA from mammalian cells can undergo N-glycan modifications (termed glycoRNA) [1][1]. The discovery relied upon a metabolic glycan labeling...
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Here is our new bioRxiv preprint that studied about critical issues for glycoRNA purification. #glycoRNA #glycotime #RNA_purification N-glycosylated molecules act as a co-precipitant in RNA purification https://t.co/LflGgA923s
biorxiv.org
A recent ground-breaking study suggested that small RNA from mammalian cells can undergo N-glycan modifications (termed glycoRNA) [1][1]. The discovery relied upon a metabolic glycan labeling...
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Online Now: Structural atlas of human primary microRNAs generated by SHAPE-MaP https://t.co/6qqWVHxrc5
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In a study published in @NatureNano, scientists at TU Delft present a new technique to identify proteins. Using this new technology, the researchers can identify individual, intact, full-length proteins, preserving all its information. Read more here👉 https://t.co/jRqb1gcHII
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