Carolien Bastiaanssen
@C_Bastiaanssen
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Postdoc at Lenstra lab @NKI_nl and interested in single-molecules, microscopy & transcription regulation
Joined July 2021
After years of development, we proudly present SPARXS in @sciencemagazine. By combining single-molecule fluorescence microscopy with next-generation sequencing, large sequence libraries can now be studied at the single-molecule level! https://t.co/M4IgCN1GZ8
science.org
At the core of molecular biology lies the intricate interplay between sequence, structure, and function. Single-molecule techniques provide in-depth dynamic insights into structure and function, but...
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New Article! Single-molecule parallel analysis for rapid exploration of sequence space https://t.co/3b5Yn7bb8I
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Do you want to perform single-molecule fluorescence measurements of thousands of different sequences in one go? Good news, our detailed protocol for SPARXS is now out in Nature Protocols! https://t.co/TX517VZpr8
nature.com
Nature Protocols - SPARXS couples single-molecule fluorescence microscopy with next-generation high-throughput sequencing to enable simultaneous profiling of millions of molecules, covering...
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We have open PhD positions! Application is now open. Apply to our and other NKI groups via the NKI PhD program at
Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other @NKI_nl labs. https://t.co/ZyuJE43wsH
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A 1,000,000th reminder the crucial importance of basic research. Ambros and Ruvkun were looking into understanding nematode genetics and development, not looking for a drug, and ended up opening an entire new area in biology
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Door analyse aan DNA-moleculen kunnen onderzoekers genetische aandoeningen beter begrijpen - van belang voor gepersonaliseerde geneeskunde en gentherapieën. Een nieuwe methode van @tudelft en @UniLeiden maakt die analyse zo'n duizend keer sneller. https://t.co/mKqlAavbUd
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Nice talk from Lisboa with @JonasRies #SMLMS2024 presenting super-resolution microscopy implemented to study dynamics in cell biology.
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Here we go again 👉🏻 #SMLMS2024 in Lisboa. Looking forward to 3 exciting days of great science. Thank you @HenriquesLab @MicrobeMatos for making this happen 🙏 @SMLM_Symposium
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🧬 Revealing DNA behaviour in record time⏱️It is now possible to measure millions of #DNA molecules within a week instead of years to decades, thanks to a new #technology now published in @ScienceMagazine 👉 https://t.co/Bn8ulB2ECo
@C_Bastiaanssen #singlemolecule #sequencing
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SPARXS was developed by the @ChirlminJoo_Lab @tudelft & the Van Noort lab @UniLeiden. It was a pleasure to team up with @ivoseverins to develop SPARXS. Thanks also to @kahutia_p and all others who contributed!
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Doctoral degree in the pocket 🥳 Thanks to all committee members for the nice discussions, all collaborators for the cool projects, and Chirlmin and all lab members for the great time in the past few years!
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Recommended conference for all Argonaute enthusiasts!
One month before the deadline for registering to the 2nd Argonaute meeting! Place limited: https://t.co/5bZS9mof7C
@apbrodersen @Argonautes_conf @MeisterLab
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RNA-guided RNA silencing by an Asgard archaeal Argonaute @fabaiwu @DCSwarts @ChirlminJoo_Lab @C_Bastiaanssen @pilar_bobadilla @k1jun_ @FinocchioGiada
#Asgard #archaea #RNAsilencing #Argonaute #evolution
https://t.co/BFLqvlDE5A
nature.com
Nature Communications - Eukaryotic Argonaute proteins participate in RNA-guided RNA silencing pathways and are divided into AGO and PIWI clades, with functional and mechanistic differences. Here,...
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It's a pleasure to see this team effort on a prokaryotic RNA-guided RNA-silencing Argonaute out today @NatureComms 😊 Please check out Fabai's post for an overview of this story's highlights!
Paper out today: “RNA-guided RNA Silencing by an Asgard archaeal Argonaute”. A wonderful, multidisciplinary project co-led with @DCSwarts @ChirlminJoo_Lab, spearheaded by @C_Bastiaanssen @pilar_bobadilla @k1jun_ @FinocchioGiada & Yanlei Feng. https://t.co/Yh3wXAYFc3
@NatureComms
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My printed PhD thesis arrived today😊 For now enjoying how the cover turned out and looking forward to discussing the contents on July 10th!
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Enjoying the first day of #BPS2024 ! If you are interested in a journey through sequence space, attend my talk on Wednesday at 13:00 in Room 113AB :)
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🔥RNA-guided RNA silencing by an Asgard archaeal Argonaute 🔥 https://t.co/VdxOczZAOe In this multidisciplinary study, we uncover that a prokaryotic Argonaute found in Asgard archaea mediates RNA-guided RNA silencing!
biorxiv.org
Eukaryotic Argonaute proteins achieve gene repression and defense against viruses and transposons by RNA-guided RNA silencing. By contrast, known prokaryotic Argonautes adopt single-stranded DNA as...
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I am happy to share our story on RNA-guided RNA silencing by an Asgard archaeal Argonaute 🥳 It was a pleasure to be part of such a synergistic collaboration! Check out Fabai's thread below for an overview of the highlights.
Excited to share a eukaryotic PIWI-related Asgard archaeal Argonaute that performs RNA-guided RNA Silencing! co-led by @DCSwarts @ChirlminJoo_Lab & me, spearheaded by @C_Bastiaanssen @pilar_bobadilla @k1jun_ Yanlei Feng & @FinocchioGiada. https://t.co/t1t3KXK5Bb
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