joshuagoldford Profile Banner
Josh Goldford Profile
Josh Goldford

@joshuagoldford

Followers
500
Following
2K
Media
1
Statuses
188

Research Scientist. Interested in quantitative biology at all scales.

Cambridge, MA
Joined April 2009
Don't wanna be here? Send us removal request.
@EdReznik
Ed Reznik
1 month
The rumors are true: there is a revival of the famous Harvard Systems Biology Theory Lunch in New York, co-organized by @flamholz and I. There is food. There is chalk. There is science. It's been fun. More to come, please reach out if you'd like to attend.
10
9
189
@fchollet
François Chollet
3 months
The most important skill for a researcher is not technical ability. It's taste. The ability to identify interesting and tractable problems, and recognize important ideas when they show up. This can't be taught directly. It's cultivated through curiosity and broad reading.
100
569
4K
@joshuagoldford
Josh Goldford
3 months
Looking for a quantum chemist with experience in reaction mechanism and kinetic modeling for a well-funded project. Please RT. DM me if you’re interested in learning more!
1
3
1
@EdReznik
Ed Reznik
4 months
For those of you hunting for your next position, please consider applying for a postdoctoral position in our lab. Our science is wild and exciting, and I promise to train and feed (yes, w/free food) you well. It doesn't hurt that we are on a publication hot streak.
4
51
143
@LiamLongo
Liam M. Longo
4 months
Is phylogenetics the only record of protein history? No!  Led by @tatsuya_corlett, we show that the history of enzymes is written into the structure of metabolism.  From there, we reconstruct a self-consistent model of metabolic and enzyme evolution. https://t.co/5GqVB5yhSe
Tweet card summary image
biorxiv.org
Phylogenetic reconstructions are a primary record of protein evolution. But what other records can attest to the deep history of enzymes, and what tools are needed to decode their meaning? Here, we...
1
8
24
@bwood_m
Brandon Wood
5 months
🚀Exciting news! We are releasing new UMA-1.1 models (Small and Medium) today and the UMA paper is now on arxiv! UMA represents a step-change in what’s possible with a single machine learning interatomic potential (short overview in the post below). The goal was to make a model
2
27
125
@Micro_Yunha
Yunha Hwang
5 months
🚨 new paper alert! https://t.co/f2Uxf9QReH During my PhD, one of the most frustrating challenges was trying to interpret genes labeled as “hypothetical proteins.” 1/n
Tweet card summary image
science.org
The genomic language model enables rapid genomic context–aware search and discovery of microbial proteins.
8
98
445
@NotinPascal
Pascal Notin
6 months
🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction. 🧵 1/9
3
49
223
@kulesatony
Tony Kulesa
10 months
Announcing Encode: AI for Science We're launching a fellowship powered by @ARIA_research to connect top AI talent with leading UK science labs to unlock the next wave of scientific breakthroughs.
9
84
298
@JorisZMR
Joris Zimmermann
1 year
If you want to know more about key mechanisms at the origin of a protometabolic reaction network and its complexification toward biochemistry, check out our latest review in ACR @ACSPublications : https://t.co/m2ZvQQnkAn Big thanks to @EmilieWerner7, @s_sodei & @MoranLabChem
Tweet card summary image
pubs.acs.org
ConspectusFamously found written on the blackboard of physicist Richard Feynman after his death was the phrase, “What I cannot create, I do not understand.” From this perspective, recreating the...
0
6
24
@OpenCatalyst
FAIR Chemistry
1 year
Introducing Meta’s Open Materials 2024 (OMat24) Dataset and Models! All under permissive open licenses for commercial and non-commercial use! Paper: https://t.co/vYSutPJT7L Dataset: https://t.co/nDZUnSiwL6 Models: https://t.co/MMPq0zKeGi 🧵1/x
16
173
613
@queenofpeat
Dr. Merritt Turetsky
1 year
Please help by sharing this. My friend and colleague- Jeff Cameron -passed away suddenly, leaving 4 young children and his wife Jenn. He was the sole breadwinner, a brilliant scientist, & a clean tech inventor. Any support for his family is appreciated.
3
20
25
@miniapeur
Mathieu
1 year
15
399
4K
@HuRibbe
Ribbe Hu Labs
1 year
Our years of work on nitrogenase assembly paid off! So proud of this paper, which demonstrates the heterologous expression of an active nitrogenase. Thanks to everybody involved for a great team effort! @NatureCatalysis, @HuRibbe, @UCIBioSci, @UCIChemistry https://t.co/cU2FnPCtlh
5
33
60
@MoranLabChem
Joseph Moran
1 year
Ever wonder why nature uses coenzymes and what role they might have played before enzymes had emerged? Check out our mini-review @ScienceAdvances summarizing our recent work on the nonenzymatic reactivity of PL(P), NADH and ATP. @QDherbassy @RJ_Mayer https://t.co/OqOcnJj8b2
4
34
174
@slavovLab
Slavov Laboratory
1 year
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. https://t.co/lAxvulC4zx
Tweet card summary image
biorxiv.org
Amino acid substitutions may substantially alter protein stability and function, but the con-tribution of substitutions arising from alternate translation (deviations from the genetic code) is...
16
282
1K
@pfau
David Pfau
1 year
I’m beyond thrilled to share that our work on using deep learning to compute excited states of molecules is out today in @ScienceMagazine! This is the first time that deep learning has accurately solved some of the hardest problems in quantum physics.
Tweet card summary image
science.org
We present an algorithm to estimate the excited states of a quantum system by variational Monte Carlo, which has no free parameters and requires no orthogonalization of the states, instead transfor...
31
179
1K
@flamholz
Avi Flamholz
1 year
Excited to be moving HOME to NYC to head the Laboratory of Environmental Microbiology @RockefellerUniv in Jan. 2025. Pics surely representative of future lab activities.
27
10
93
@gaurav_ven
Gaurav Venkataraman
1 year
For the past few years, we have been working to manufacture *perfect* drug product, starting with gene therapies. We've been quietly building hardware, doing science, and serving our first customers. But now we want to say Hi: https://t.co/faWy0l94SC
triskbio.com
Trisk Bio provides scalable, preclinical AAV manufacturing for research grade and NHP studies.
10
20
79