Ribbe Hu Labs
@HuRibbe
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Metalloprotein assembly and catalysis; bioinorganic chemistry; structural biology; spectroscopy; microbiology
Joined June 2020
Our home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! https://t.co/SRSQEqHGiP Please apply and/or share this post! @UCIBioSci; @UCIrvine
recruit.ap.uci.edu
University of California, Irvine is hiring. Apply now!
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Our latest work on the nitrogenase-like methylthio-alkane reductase is now out @NatureCatalysis
https://t.co/NxFGaYg7Xb We biochemically and structurally characterized the methylthio-alkane reductase, a metalloenzyme that can produce ethylene from organic sulfur compounds.
nature.com
Nature Catalysis - Methylthio-alkane reductases are recently discovered enzymes that can produce methanethiol and small hydrocarbons from methylated sulfur compounds. Now the cryo-EM structure of a...
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Great talk by Joe Rebelein yesterday evening at the MoTEC 2025 at long beach! Congratulations to the EMBO young investigator lecture! Much deserved 👍
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Congratulations to Bryan Neumann from our collaborator Shane Gonen’s lab on receiving the Barbara K. Burgess Postdoctoral Fellowship Award — a well-deserved honor! @GonenShane @HuRibbe @UCIBioSci
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Using spectroscopic and structural approaches we gained new insights into the role of #ferredoxins in N2 fixation. Just published in @ChemEurJ: https://t.co/pbeYoZDNzE! Great work by @HollyGAddison and fantastic excellent with @AJPierik.
chemistry-europe.onlinelibrary.wiley.com
Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and...
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You may ask: “why study ancient enzymes? Who cares what life looked like 3 billion years ago?” Because evolution may hold answers to problems we still struggle with, and it can guide our efforts. New paper from our lab! 🧵
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Our second paper was published online within the same week 😊! Thanks everyone for their hard work! @ScienceAdvances, @HuRibbe, @UCIBioSci, @UCIChemistry Heterologous synthesis of a simplified nitrogenase analog in Escherichia coli | Science Advances
science.org
Heterologous synthesis of a nitrogenase analog (NifH/NifEN) in E. coli enables N2 reduction and incorporation of N into biomass.
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Excited to share our latest work highlighting the crucial role of belt-sulfur mobilization in nitrogenase catalysis. A big thank you to everyone who contributed to this effort! @ChemCatalysis, @HuRibbe, @UCIBioSci, @UCIChemistry
https://t.co/ytxyWWhjcd
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I'm truly excited to announce our new publication in @Nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @AnujR2d2 for the fantastic illustration! LINK: https://t.co/OmMRWWtNR8
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Congrats Leo & Joe! This is awesome!
Congrats to @Leo_Ernst_2 for successfully defending his PhD thesis @mpi_marburg !🎊🍾🎉🥳 The first doctor from the Rebelein lab.
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The Department of Molecular Biology and Biochemistry in the Charlie Dunlop School of Biological Sciences at UC Irvine invites applications for a tenure-track Assistant Professorship in Structural Biology and Biochemistry: https://t.co/9t2Shv2eVe
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Our latest work on a #nitrogenase-like enzyme, the methylthio-alkane reductase which surprisingly also contains large nitrogenase metalloclusters, the P-cluster and the [Fe8S9C]- (L)-cluster is now online: https://t.co/k6E8Sf1A99 Have a look at the 🧵 by @AnaLagoMaciel.
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Our story made the cover! Really proud of it. Thank you so much Nature Catalysis for supporting our work! @NatureCatalysis, @HuRibbe, @UCIBioSci, @UCIChemistry
https://t.co/OFeZGHKy8S
https://t.co/kD3inCKbY2
nature.com
The generation of metallocentre-containing nitrogenase for N2 fixation in a non-diazotrophic host has proven to be an intricate task. Now, Markus W. Ribbe,...
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Congrats for finally demonstrating the expression of metallocluster replete nitrogenases in E. coli. That's a fantastic advancement!
Our years of work on nitrogenase assembly paid off! So proud of this paper, which demonstrates the heterologous expression of an active nitrogenase. Thanks to everybody involved for a great team effort! @NatureCatalysis, @HuRibbe, @UCIBioSci, @UCIChemistry
https://t.co/cU2FnPCtlh
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Our years of work on nitrogenase assembly paid off! So proud of this paper, which demonstrates the heterologous expression of an active nitrogenase. Thanks to everybody involved for a great team effort! @NatureCatalysis, @HuRibbe, @UCIBioSci, @UCIChemistry
https://t.co/cU2FnPCtlh
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This is the most important video you'll see today!
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We are proud to announce a $50M gift from Charlie Dunlop, founder of Ambry Genetics. Our school will now be known as the Charlie Dunlop School of Biological Sciences. This gift will significantly impact our school and the broader scientific community. #DunlopSchool @FrankLaFerla
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