jonathan corcoran
@jonathanco43807
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Professor of Neurobiology at Kings College London. Drug discovery for treatment of nerve injury and neurodegeneration.
London UK
Joined April 2025
Nerve injury and neurodegeneration, numerous pathways go wrong, drugs that activate transcription factors have the power to restore those pathways. C286 is a drug that does that in spinal cord injury
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Steve job once said: "The most powerful person in the world is the storyteller" But most people don't know how to tell stories 5 Storytelling techniques to make your business unstoppable:
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Check out our special collection on #neuroimmunology that is online now! https://t.co/q6az097S61
#AAI2025
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š£š£Thalamus on FIREš„Thalamic microglia density on ER176 PET is highest in progressive MS followed by relapsing MS & controls. ER176 PET stands out as a promising molecular imaging biomarker of progression in MS https://t.co/DA82QZjbFH
@nurneyal @LauraAiras1
academic.oup.com
Zeydan et al. report that thalamic microglia density on 11C-ER176 PET is highest in progressive multiple sclerosis, followed by relapsing multiple sclerosi
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Epigenetic (methylation, biological) age is associated with increased risk of dementia and brain structural changes (including atrophy). From UK Biobank's 280,000 participants, ~4,800 cases of dementia over 14-year follow-up https://t.co/nZSUXsZwUY
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Redefining CNS immune privilege | Nature Reviews Immunology
nature.com
Nature Reviews Immunology - In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to...
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Online now: A hierarchy of intestinal antigens instructs the CD4+ T cell receptor repertoire
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Online now: Inflammasome signaling in astrocytes modulates hippocampal plasticity
cell.com
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in...
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How does our new drug work? 1. Orally available, 2. Engages receptor, 3. brain available, 4. No adverse events, 5. Multiple pathways targeted. 6. Potential treatment for acute nerve injury, e.g. spinal cord injury and neurodegenerative diseases, e.g. motoneuron disease
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Brain Growth Charts Reveal Early Cognitive Development Patterns Researchers have developed the first normative brain functional growth charts from birth to six years old, mapping how key neural networks mature alongside cognitive milestones. MRI scans from over 1,000 children
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Today, NIH announced a new initiative to expand innovative, human-based science while reducing the use of animals in research. This aligns with @US_FDAās initiative to reduce testing in animals.
nih.gov
New initiative aims to reduce use of animals in NIH-funded research.
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Our 2025 Alzheimerās Disease Facts and Figures is a call to action ā to do more, to make more progress, and to give people more reasons to believe that our vision of a world without Alzheimerās and all other dementia is possible.
These numbers tell the story of #AlzheimersInAmerica. Our families, our economy and our communities are straining under the weight of this disease. But together, we can make a difference. Watch šļø, share ā”ļø and join the fight to end Alzheimerās š. #ENDALZ
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New Research: Current limitations in technology-based cognitive assessment for severe mental illnesses: a focus on feasibility, reliability, and ecological validity https://t.co/S8xtbvofcn
#FrontiersIn #BehavioralNeuroscience
frontiersin.org
Cognitive impairments are frequently observed in subjects with severe mental illnesses (SMI), leading to a remarkable impact in their real-world functioning....
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A new Science study finds that different dendritic segments of a single neuron follow distinct rules. The results challenge the idea that neurons follow a single learning strategy and offer a new perspective on how the brain learns and adapts behavior š:
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Science is about helping society, you do that by defining mechanisms related to disease, and ultimately discovering drugs. To achieve those goals you need to surround yourself with like minded people for the difficult journey, eventually you will arrive at the destination.
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