I am very excited to share that our paper has now been published in @Nature. We describe a single-cell correlate of theta-gamma phase amplitude coupling and show how these cells are involved in the cognitive control of working memory storage processes.

Huge thanks to @UeliRutishauser @AMamelak and all co-authors!! @CedarsSinai #Neuroscience @NeuroCellPress.

5/ Our findings suggest a single-neuron mechanism linking WM maintenance and LTM encoding. It sheds light on how working and long-term memory interact at a cellular level, revealing that WM maintenance serves as a gateway to memory formation in the hippocampus.

4/ However, hippocampal memory-selective neurons fired more robustly for items that were previously encoded with strong WM activity from a simultaneously recorded category neuron, suggesting significant ties between the two neuron groups.

3/ We further found that in the hippocampus memory-selective neurons, which respond differently to familiar vs. novel items during LTM retrieval, didn’t overlap with category neurons. While category neurons contributed to LTM formation, they were not involved in LTM retrieval.

2/ Importantly, while both hippocampus and amygdala neurons showed category-selective persistent activity, only hippocampal neurons showed a predictive relationship between WM and LTM. This activity was stronger for items later remembered with high confidence.

1/ In our study, we recorded single-neuron activity from the hippocampus and amygdala in patients performing WM and LTM tasks. We show that neurons selective to picture category during encoding show persistent activity during WM when the preferred category is maintained in mind.

We are delighted to share that our new paper published today in @NeuroCellPress! We show that the persistent activity of single neurons during working memory (WM) maintenance predicts long-term memory (LTM) formation in the human hippocampus. 👇

RT @rlmcelreath: Germany tried this. It is a disaster. Pushes ppl out of research. The positions they are supposed to transition into don't….

With @UeliRutishauser @AMamelak @kaminski_janek.

Check out our new preprint in which we show how single neuron activity of items stored in working memory in the hippocampus relates to the encoding of those items into long-term memory. The stronger the persistent activity during WM, the more successful the encoding into LTM.

RT @Nature: Nature research paper: Control of working memory by phase–amplitude coupling of human hippocampal neurons .

RT @Nature: How does the human brain temporarily store information without losing track of it?

Huge thanks especially to @UeliRutishauser and @AMamelak and to all co-authors @kaminski_janek, @singleunitgps @MichaelKyzar00, Umais Khan, Chrystal Reed, Yousef Salimpour, Taufik Valiante, William Anderson.

RT @UeliRutishauser: New open source data release of human single neuron recordings in MTL and MFC during working memory task out today! Ca….

RT @martin_hebart: I am looking for two postdocs to join us at Giessen University @jlugiessen, in collab. with the Max Planck Institute @MP….

RT @caro_charp: 🚨 Job altert!🚨.Come join us in lovely Maryland! The Social Learning and Decisions lab @bsosumd is recruiting a full-time la….

Big thank you to all contributors!.@UeliRutishauser @kaminski_janek @AMamelak @singleunitgps Umais Khan, Chrystal Reed, Yousef Salimpour, Taufik Valiante, William Anderson.

Check out our new preprint on the involvement of theta-gamma phase amplitude coupling in controlling working memory-related persistent activity in the human hippocampus!

RT @martin_hebart: I’m hiring! If you are interested in doing a PhD or postdoc in computational cognitive neuroscience of visual object rec….