Jason S Knight
@jasonsknight
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rheumatologist ๐งฉ๐ | researcher of #antiphospholipid syndrome, lupus, COVID-19, diabetes, neutrophils, NETs ๐ธ๏ธ๐ | shoutout to Sparky the beagle ๐ฃ๏ธ๐ถ
Ann Arbor
Joined September 2013
Squirrel if you think I am unwilling to wait for you to come down you would be incorrect because I will in fact wait as long as it takes ๐ฏ
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Commentary: Neutrophils take center stage in #VEXAS syndrome pathogenesis- https://t.co/akQD22otdZ Ajay Tambralli & Jason S. Knight @UMichMedSchool provide an editorial on Ge Dong et al.: https://t.co/BF7y08rYlY
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๐๐ธ๏ธ๐ Intensive physical training induces NET release in athletes https://t.co/tD64XdRU1t
nature.com
Scientific Reports - Intensive physical training induces NET release in athletes
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Study identifies CCN1/CCN2 as key drivers of organ damage via vessel thickening in APS #Vasculopathy (affecting 10โ20% of #APS pts). Existing biologics targeting CCN2 may offer novel treatment avenues: https://t.co/tb6H5RBe26
#MedTwitter @jasonsknight @umichmedicine
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Researchers at Johns Hopkins are studying the impact of antiphospholipid syndrome (APS) on patients' lives. If you're living with APS, theyโd love to hear from you. ๐ Take the survey: https://t.co/CPddf49pU5
#APS #AutoimmuneDisease #ChronicIllness #APSResearch #APSSurvey
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Research highlights CCN1 & CCN2 as key drivers of APS #vasculopathy, a serious complication affecting >20% of #APS patients. Targeting these proteins may offer a new treatment path. Long-term tracking studies are now underway: https://t.co/BekfhRdWrP
@jasonsknight @umichmedicine
newswise.com
Research identifies previously unknown treatment targets for antiphospholipid syndrome organ damage
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Researchers, including @jasonsknight, have uncovered new treatment targets for APS vasculopathy by pinpointing elevated CCN1 & CCN2 proteins using singleโcell sequencing. Read more:
michiganmedicine.org
Antiphospholipid syndrome vasculopathy is often overlooked in patients and can result in organ failure. Researchers at University of Michigan Health uses skin biopsies to pinpoint features in blood...
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Excited to share our research, spearheaded by MSTP trainee @nathanec1, with contributions from ~9 research labs, focused on the changing roles of brain fibroblasts (and immune cells) in brain injury. Thx in particular to @AnnaMolofskyLab, Tom Arnold lab. https://t.co/j2gWnMvmfX
nature.com
Nature - Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate...
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โค๏ธ๐ @CircAHA Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling https://t.co/zv8RooNaOA
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38th annual AMLI meeting! ๐งช๐ค Great opening talk in this autoimmunity session by Bryant England ๐
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๐จThrilled to share our new article regarding NETs in APS & their association with thrombosis!! A labor of love- so glad to see it finally published. Link: https://t.co/WvFFOykyTS Right on time for #HemeOnc #match2025 :) Thank you Drs @jasonsknight, Alfred Lee and Sharda for
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Pet ownership is associated with higher cognition & larger brain structures. These effects are the largest in dog owners.
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ICYMI, our review article about antiphospholipid syndrome in @ACR_Journals is now nicely formatted (and remains free) Antiphospholipid Syndrome: An Antibody-Mediated Disease With Emerging Therapeutic Opportunities ๐ฎ๐๐ ๐ Link in the replies...
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A Disrupted Adenosinergic Axis Facilitates Platelet Activation in APS: Exploring a Novel Therapeutic Target https://t.co/NLrOr2wbmS
ashpublications.org
Key PointsAPS platelets have a reduced ability to produce extracellular adenosine, disrupting purinergic signaling and likely favoring thrombosis.A2AR acti
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๐ฉธ๐ We wrote a paper for @BloodAdvances about antiphospholipid syndrome (APS), platelets, and purinergic signaling, with an eye toward potential therapeutic targets. See the Replies for a link to the article...
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