Aron Jaffe
@jaffeab
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SVP @ https://t.co/5bCQBx9DVy;Former SVP Head of Research @chromamedicine;EIR @ThirdRockV;Reg Med, uBiome group leader/Resp DA co-lead @NovartisScience. Opinions mine
Boston, MA
Joined October 2011
Our work describing the development of a potent epigenetic editor targeting human #PCSK9 for durable reduction of LDL-C is out in @NatureMedicine today! Cc: @chromamedicine @nchromabio 1/9 https://t.co/cnelNtMT0W
nature.com
Nature Medicine - Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both...
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I was today years old when I learned that Fig Newtons were named after Newton, MA! Thanks @AnnaFaragoMD Cc: @Seredev1
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Congrats @LukeGilbertSF !!!
A study out today in @NatureGenet from Core Investigator @LukeGilbertSF, @li_haolong & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
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Exciting development in the push to leverage AI for hypothesis generation! Note that it can be A LOT of work to validate a hypothesis before calling it a 'discovery' Research institute FutureHouse debuts AI scientist Kosmos and for-profit spinoff -
endpoints.news
FutureHouse launches Kosmos widely & creates Edison Scientific spinoff to manage AI tools.
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This is the neighborhood I grew up in in Chicago. Rogers Park. Cell video shows federal agents removing man from vehicle in Chicago https://t.co/e3F5JhGuMj via @YouTube
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One for the ages. One to hang on to. Too bad it’s over. Get ready for Spring Training & the WBC.
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Will Smith discussing Yoshinobu Yamamoto's performance.
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Why is nobody talking about the ball boy on the first base line? Put that kid in the game!
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Congratulations to @JMaraganore and the entire @corserahealth team!
Today, we announced the filing of our first clinical trial notification (CTN) to initiate a Phase 1 clinical trial of our lead RNAi preventive medicine program for #cardiovasculardisease. Read the full details here: https://t.co/pH0U8yDhO2
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The information encoded in the retina photo but not discernible by expert clinicians is remarkable. Now add the retinal vessels as a window into the inflammaging process and the related genomic underpinnings https://t.co/fU6w7IsqZM
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‘….Then they came for me And there was no one left To speak out for me’ Immigration Crackdown Spreads Through Chicago, Including Wealthy Neighborhoods https://t.co/72JEFVtk5s via @NYTimes
nytimes.com
Federal agents detained a man on the city’s North Side on Friday, and residents emerged from their homes, yelling and blowing whistles.
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Congratulations to @JShendure on being elected to the @theNAMedicine!
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So proud of @KimmieNgMD for continuing to be a driving force behind efforts to understand and address young-onset colorectal cancer @DanaFarber @DFarberYoungCRC
open.spotify.com
Chasing Life · Episode
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Part 2 from @LifeSciVC didn’t disappoint! I know I’m a day behind, but looking forward to reading Part 3!
Twenty Years In Early Stage Biotech VC (Part 2): People Continuing in the trifecta of anniversary blogs, here are a few observations on people, talent and teams: · The power of luck! · Life is short… live by the NAR (No Asshole Rule) · By the time you know you need a
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Amazing piece by @LifeSciVC on the Science of biotech startups. Can't wait for Part 2! Twenty Years In Early Stage Biotech VC (Part 1)
lifescivc.com
In the blink of an eye, twenty years have passed: in mid-October 2005, I joined Atlas Venture as a principal on the global life science team. We closed Fund VII a few months after I joined; and,...
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Your periodic reminder that #genetherapies work DB-OTO Gene Therapy for Inherited Deafness | New England Journal of Medicine
nejm.org
Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...
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I <3 the #nakedmolerat
Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing
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His Off-the-Grid Vacation Was Interrupted by Winning a Nobel Prize
nytimes.com
Fred Ramsdell found out about his Nobel Prize nearly 12 hours after it was announced because he was on vacation in the Rockies.
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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