Jan Van den Bossche Lab
@immunometlab
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We study macrophages! We aim to understand and reshape macrophage immunometabolism to improve function and disease outcome. 🧫🔬🥼🧑🔬 🦠🧑💻🏥 #playforward
Amsterdam UMC, VUmc
Joined September 2019
RT @NatMetabolism: #Throwback. COMMENT | J Van den Bossche et al. A call for accessible tools to unlock single-cell immunometabolism resea….
nature.com
Nature Metabolism - Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for...
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No (innate immune) training without lactate…. I was invited by @MolecularCell to write a spotlight paper and discuss the recent work by Mihai Netea and colleagues in @CellCellPress on lactate production and downstream histone lactylation in the induction of trained immunity ⬇️.
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The abstract submission for the 2025 EMDS meeting in Edinburgh is open: I very much look forward to this conference and finally visiting Schotland for the first time 😍.
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RT @MartinGuilliams: Superb study of the effect of Trypanosomiasis infection on Kupffer cell function even weeks after cure and elimination….
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RT @MartinGuilliams: Joining 🦋 @martinguilliams.bsky.social. Let’s see if we can #EMDS2024 Vienna #macrophage and #dendriticcell fans there!.
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Supported by @ImmunoMetEurope, @ImmunoMetNet, @BSI_immunomet, @ImmunoMet @immunemet, @SocietyEuropean and others working on immunometabolism, the aim of the Immunometabolism journal @Immunometaboli2 is to further grow and to become THE go-to journal in this exciting field.
Our journal welcomes short commentary articles to put recently published high-impact work in a broader perspective. 🥳🥳🥳Interests in writing a commentary, contact our EiC Professor Jan Van den Bossche.@immunometlab and the EB member Professor Sarah Dimeloe @SarahDimeloeLab.
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A potential immunometabolic effect of antidepressant drug SSRI❔⬇️.
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SLC13A3 story 2 (the detrimental one 🚫): Itaconate import into cancer cells via SLC13A3 was even more recently discovered to impair anti-tumor immunity by making tumors resistant to ferroptosis. @Cancer_Cell.
cell.com
In brief, Lin et al. demonstrate that SLC13A3 functions as an itaconate transporter, allowing tumor cells to uptake macrophage-derived itaconate through SLC13A3. This process contributes to tumor...
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SLC13A3 story 1 (the beneficial one ✅): SLC13A3 was recently discovered to be an itaconate importer that improves hepatic antibacterial innate immunity .@Dev_Cell
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Next-generation immunotherapy opportunities using “T-linker” ⬇️.
A linker-based platform integrates multiple therapeutic modules into a single ‘Multi-TAC’, which can engage multiple tumor-targeting immune cells within the tumor microenvironment #NBThighlight.
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RT @RyanLab_MBU: 📢Last weeks #immunometabolism discoveries @Bims_BiomedNews 👇👇👇. Highlights:.I) CENCAT - a new too….
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CENCAT; an immunometabolic profiling tool that blends the @SCENITHmetab approach with BONCAT click chemistry to measure metabolic dependencies of cell subsets.@CellRepMethods paper online now ➡️
cell.com
Vrieling et al. present CENCAT, a technique to perform in-depth immunometabolic phenotyping in complex samples. They utilize fluorescent labeling of non-toxic unnatural amino acids to determine...
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RT @RyanLab_MBU: 📢Last weeks #immunometabolism discoveries @Bims_BiomedNews 👇👇👇. It's a big one this week, check i….
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No time for daily physical activity during your busy work week? .No problem! . This @NatureAging paper shows that a “weekend warrior pattern” yields similar brain health benefits. 💪🏼 🏃🏻♂️ 🚲 🧠 .
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