Irina Armean, PhD
@imarmean
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#diagnostics #bioinformatics scientist: DNA #variation and their impact, PhD #proteomics, PostDoc #dna-variation. #STEMAmbassadors. Views are my own. 🧬 🇪🇺
Cambridge, England
Joined January 2016
Great opportunity for early stage researchers ready for independence!
If you are a senior postdoc ready to start your own research group, this is a fantastic opportunity. At FIMM we host some of the globally most exciting genetic and molecular data and for a strange reason Finland ends up at the top of the happiest nation list year after year.
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Useful cheat-sheet for general genomics quantitative properties:
Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)
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📣NEW TOOL! Wish there was a tool that made calculating existing #PolygenicScores and #PolygenicRiskScores in new datasets easier? We @PGSCatalog have made just that! INTRODUCING pgsc_calc: an open-source pipeline to calculate PGS using nextflow https://t.co/ahsG91TiKV
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Please RT: We are delighted to announce that the Department of Human Genetics at the University of Michigan is searching for a tenure-track faculty member at the Assistant Professor level! Please apply here: https://t.co/AEC3ZcBcUs.
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🎉Final version of our dosage sensitivity study out today @CellCellPress! https://t.co/2ST1FztGcl Explored CNV associations across 54 phenotypes in ~1M genomes Since @medrxivpreprint in 2021: added 200k samples & 22 phenotypes thanks to @GeneDx @ESTbiobank @vumcdbmi 🧵👇 1/6
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Our paper on rare variant associations in the UK Biobank is out in Cell Genomics today!
cell.com
Karczewski et al. generated a massive-scale association dataset between rare genetic mutations and thousands of diseases and traits and released these data in the Genebass browser. They quantify the...
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Lovely weather in Vienna for some science! #ESHG2022 Two notes: -I’m hiring! Please say hello if you’d like to chat about opportunities :) -I’ll talk about some hot-off-the-cloud analyses of regional missense constraint on Monday (S22 session)
On my way to #ESHG2022 in Vienna! Looking forward to meetings colleagues and chatting science.
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PRS-CSx has arrived. Congrats to @getian107 @Yunfeng_Ruan @hailianghuang and colleagues Improving polygenic prediction in ancestrally diverse populations https://t.co/lta9r3bnob
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Great postdoc opportunity with @ksamocha ! Do RT! Do apply!
I'm hiring postdocs to join my team at @CGM_MGH & Broad! We study patterns of rare variation in large genomic datasets (like gnomAD), and leverage those into insights about genetic risk for disease. If you are interested, please reach out or apply here: https://t.co/2MOkF3sij8
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👇👇👇 most important advice to genomics trainees. To understand your data, and its error modes, find a simple informative plot of a slice of your data (read alignment etc) and plot for 100+ random instances. Use your brain’s pattern recognition. Takes minutes, saves months.
@nilshomer Visualise *everything* Look at sequence reads, sequence assemblies, data, alignments, SNPs, PCA all of your numerical data. Get into the *details* of your data
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There are different versions of the human genome annotation but which do you use? The Matched Annotation from @NCBI and EMBL-EBI (MANE) collaboration is the answer and brings new meaning to the phrase: two heads are better than one. https://t.co/piRx08NP2b
ebi.ac.uk
Researchers from the MANE collaboration bring you the most comprehensive human genome annotation dataset to date.
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Cecilia (@ceclindgren) is fabulous and a true leader in the field of genomics. Great chance to join her team. Details below 👇
Come and work with us! The Lindgren @ceclindgren Lab at the Big Data Institute @bdi_oxford in Oxford is looking to hire a junior statistical geneticist/bioinformatician (finished or about to finish undergrad/masters): https://t.co/uYgkbzIbO2. Please share!
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Come and work with us! The Lindgren @ceclindgren Lab at the Big Data Institute @bdi_oxford in Oxford is looking to hire a junior statistical geneticist/bioinformatician (finished or about to finish undergrad/masters): https://t.co/uYgkbzIbO2. Please share!
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Our lab is hiring! https://t.co/nPNeJO2wJX Come join our mission to cure prion disease through groundbreaking science. The folks who work here love our lab — you will too!
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🚨 Last few days to apply for these posts - deadline is Thursday. It am truly excited by this project and working with this awesome team (kick-ass female mentors anyone?)! If you know anyone who might be interested, please please share! Thank you!
📢 Looking for postdocs to lead an exciting new industry collaboration with @joannahowson @novonordisk and an awesome team including @ceclindgren and @carolinefwright 🌟 Early-career postdoc: https://t.co/NK2ZPLIqb7 Senior role: https://t.co/4R5WMZRVCM Please share and RT! 1/4
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Join EMBL to complete your PhD at one of our six sites across Europe! The EMBL International PhD Programme is open for applications until 19 April 2022. #PhD #research Important information about the application process can be found here: https://t.co/PgpjqfcGL9
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Stay at the forefront of rare disease genomics! Register for #GRD22 by 21 March for an update on the latest approaches in common and rare variant research, as well as excellent international peer networking. 🌐 https://t.co/HFAeWzQK8U
#RareDiseases #Mendelian @poseypod
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This is happening tomorrow, Monday! Do sign up to attend: https://t.co/0UkxX4xSvw
@mkveerpn @nickywhiffin @broadinstitute @covid19_hgi
cpm.ox.ac.uk
We are delighted that @mkveerpn will be joining us on 7th February to give his talk, 'The Global COVID-19 Host Genetics Initiative: Mapping of the Host Genetic Architecture of COVID-19 while Improving Diversity in Genetics'. Register here to attend: https://t.co/2IJvMWzSWI
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Two amazing @CPMOxford talks over the next 2 weeks: - 3rd Feb the incredible @HeidiRehm🤩 on a global ecosystem for genomic medicine - 7th Feb the awesome @mkveerpn💪 on @covid19_hgi, diversity, collaboration and outreach Sign up for both: https://t.co/PJ6ugA51n6 Please share!
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We can now obtain subcellular maps for both RNA and protein in the same experiment and show the dynamic changes in location of both in the unfolded protein response. Introducing LoRNA (the LOPIT for RNA)
biorxiv.org
Existing methods to analyse RNA localisation are constrained to specific RNAs or subcellular niches, precluding the cell-wide mapping of RNA. We present Localisation of RNA (LoRNA), which maps, at...
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